Whole-body connectome of a segmented annelid larva
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 17, 2024
Abstract
Nervous
systems
coordinate
effectors
across
the
body
during
movements.
We
know
little
about
cellular-level
structure
of
synaptic
circuits
for
such
body-wide
control.
Here
we
describe
whole-body
connectome
a
segmented
larva
marine
annelid
Platynereis
dumerilii
.
reconstructed
and
annotated
over
9,000
neuronal
non-neuronal
cells
in
serial
electron
microscopy
dataset.
Differentiated
were
classified
into
202
92
cell
types.
analyse
modularity,
multisensory
integration,
left-right
intersegmental
connectivity
motor
ciliated
cells,
glands,
pigment
muscles.
identify
several
segment-specific
types,
demonstrating
heteromery
larval
trunk.
At
same
time,
segmentally
repeated
types
head,
trunk
segments
pygidium
suggest
homology
all
segmental
regions.
also
report
descending
ascending
pathways,
peptidergic
multi-modal
mechanosensory
girdle.
Our
work
provides
basis
understanding
coordination
an
entire
animal.
Language: Английский
Mechanism of barotaxis in marine zooplankton
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: March 1, 2023
Abstract
Hydrostatic
pressure
is
a
dominant
environmental
cue
for
vertically
migrating
marine
organisms
but
the
physiological
mechanisms
of
responding
to
changes
remain
unclear.
Here
we
uncovered
cellular
and
circuit
bases
barokinetic
response
in
planktonic
larva
annelid
Platynereis
dumerilii
.
Increased
induced
rapid,
graded
adapting
upward
swimming
due
faster
beating
cilia
head
multiciliary
band.
By
calcium
imaging,
found
that
brain
ciliary
photoreceptors
showed
changes.
The
animals
mutant
opsin-1
had
smaller
sensory
compartment
larvae
diminished
responses.
synaptically
connect
band
via
serotonergic
motoneurons.
Genetic
inhibition
cells
blocked
pressure-dependent
increases
beating.
We
conclude
function
as
sensors
activate
through
signalling
during
barokinesis.
Language: Английский
Mechanism of barotaxis in marine zooplankton
eLife,
Journal Year:
2024,
Volume and Issue:
13
Published: Feb. 6, 2024
Hydrostatic
pressure
is
a
dominant
environmental
cue
for
vertically
migrating
marine
organisms
but
the
physiological
mechanisms
of
responding
to
changes
remain
unclear.
Here,
we
uncovered
cellular
and
circuit
bases
barokinetic
response
in
planktonic
larva
annelid
Platynereis
dumerilii
.
Increased
induced
rapid,
graded,
adapting
upward
swimming
due
faster
beating
cilia
head
multiciliary
band.
By
calcium
imaging,
found
that
brain
ciliary
photoreceptors
showed
graded
changes.
The
animals
mutant
opsin-1
had
smaller
sensory
compartment
larvae
diminished
responses.
synaptically
connect
band
via
serotonergic
motoneurons.
Genetic
inhibition
cells
blocked
pressure-dependent
increases
beating.
We
conclude
function
as
sensors
activate
through
signalling
during
barokinesis.
Language: Английский
Mechanism of barotaxis in marine zooplankton
eLife,
Journal Year:
2024,
Volume and Issue:
13
Published: Sept. 19, 2024
Hydrostatic
pressure
is
a
dominant
environmental
cue
for
vertically
migrating
marine
organisms
but
the
physiological
mechanisms
of
responding
to
changes
remain
unclear.
Here,
we
uncovered
cellular
and
circuit
bases
barokinetic
response
in
planktonic
larva
annelid
Platynereis
dumerilii
.
Increased
induced
rapid,
graded,
adapting
upward
swimming
due
faster
beating
cilia
head
multiciliary
band.
By
calcium
imaging,
found
that
brain
ciliary
photoreceptors
showed
graded
changes.
The
animals
mutant
opsin-1
had
smaller
sensory
compartment
larvae
diminished
responses.
synaptically
connect
band
via
serotonergic
motoneurons.
Genetic
inhibition
cells
blocked
pressure-dependent
increases
beating.
We
conclude
function
as
sensors
activate
through
signalling
during
barokinesis.
Language: Английский