Inhibitory circuits coordinate leg movements duringDrosophilagrooming DOI Creative Commons
Durafshan Sakeena Syed, Primoz Ravbar, J. Simpson

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 6, 2024

Limbs execute diverse actions coordinated by the nervous system through multiple motor programs. The basic architecture of neurons that activate muscles articulate joints for antagonistic flexion and extension movements is conserved from flies to vertebrates. While excitatory premotor circuits are expected establish sets leg work together, our study uncovered a new instructive role inhibitory circuits: their ability generate rhythmic movements. Using electron microscopy data Drosophila nerve cord, we categorized ~120 GABAergic 13A 13B hemi-lineages into classes based on similarities in morphology connectivity. By mapping synaptic partners, pathways inhibiting specific groups neurons, disinhibiting counterparts, inducing alternation between extension. We tested function optogenetic activation silencing, using an in-depth ethological analysis during grooming. combined anatomy behavior findings construct computational model can reproduce major aspects observed behavior, confirming sufficiency these rhythms.

Language: Английский

Inhibitory circuits coordinate leg movements duringDrosophilagrooming DOI Creative Commons
Durafshan Sakeena Syed, Primoz Ravbar, J. Simpson

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 6, 2024

Limbs execute diverse actions coordinated by the nervous system through multiple motor programs. The basic architecture of neurons that activate muscles articulate joints for antagonistic flexion and extension movements is conserved from flies to vertebrates. While excitatory premotor circuits are expected establish sets leg work together, our study uncovered a new instructive role inhibitory circuits: their ability generate rhythmic movements. Using electron microscopy data Drosophila nerve cord, we categorized ~120 GABAergic 13A 13B hemi-lineages into classes based on similarities in morphology connectivity. By mapping synaptic partners, pathways inhibiting specific groups neurons, disinhibiting counterparts, inducing alternation between extension. We tested function optogenetic activation silencing, using an in-depth ethological analysis during grooming. combined anatomy behavior findings construct computational model can reproduce major aspects observed behavior, confirming sufficiency these rhythms.

Language: Английский

Citations

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