Retinal ganglion cells encode the direction of motion outside their classical receptive field DOI Creative Commons
Serena Riccitelli, Hadar Yaakov, Alina S. Heukamp

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 122(1)

Published: Dec. 30, 2024

Retinal ganglion cells (RGCs) typically respond to light stimulation over their spatially restricted receptive field. Using large-scale recordings in the mouse retina, we show that a subset of non- direction-selective (DS) RGCs exhibit asymmetric activity, selective motion direction, response stimulus crossing an area far beyond classic The extraclassical arises via inputs from distal zone and is enhanced by desensitization mechanisms inherent DS component, creating network neurons responding toward optic disc. Pharmacological manipulations revealed necessity glycinergic amacrine for this response. vivo recordings, identified similar responses lateral geniculate nucleus neurons, suggesting such non conventional information transferred downstream structures. Our results suggest complex integration direction processing across visual field, which classical field boundaries.

Language: Английский

Retinal ganglion cells encode the direction of motion outside their classical receptive field DOI Creative Commons
Serena Riccitelli, Hadar Yaakov, Alina S. Heukamp

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 122(1)

Published: Dec. 30, 2024

Retinal ganglion cells (RGCs) typically respond to light stimulation over their spatially restricted receptive field. Using large-scale recordings in the mouse retina, we show that a subset of non- direction-selective (DS) RGCs exhibit asymmetric activity, selective motion direction, response stimulus crossing an area far beyond classic The extraclassical arises via inputs from distal zone and is enhanced by desensitization mechanisms inherent DS component, creating network neurons responding toward optic disc. Pharmacological manipulations revealed necessity glycinergic amacrine for this response. vivo recordings, identified similar responses lateral geniculate nucleus neurons, suggesting such non conventional information transferred downstream structures. Our results suggest complex integration direction processing across visual field, which classical field boundaries.

Language: Английский

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