An integrative data-driven model simulating C. elegans brain, body and environment interactions DOI Creative Commons
Mengdi Zhao, Ning Wang, Xinrui Jiang

et al.

Nature Computational Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

The behavior of an organism is influenced by the complex interplay between its brain, body and environment. Existing data-driven models focus on either brain or body–environment. Here we present BAAIWorm, integrative model Caenorhabditis elegans, which consists two submodels: body–environment model. was built multicompartment with realistic morphology, connectome neural population dynamics based experimental data. Simultaneously, used a lifelike three-dimensional physical Through closed-loop interaction submodels, BAAIWorm reproduced zigzag movement toward attractors observed in C. elegans. Leveraging this model, investigated impact system structure both activities behaviors. Consequently, can enhance our understanding how controls to interact surrounding elegans that simulates interactions biophysically detailed neuronal capable replicating species.

Language: Английский

Functional analysis of conserved C. elegans bHLH family members uncovers lifespan control by a peptidergic hub neuron DOI Creative Commons
G Robert Aguilar,

Berta Vidal,

Hongzhu Ji

et al.

PLoS Biology, Journal Year: 2025, Volume and Issue: 23(1), P. e3002979 - e3002979

Published: Jan. 6, 2025

Throughout the animal kingdom, several members of basic helix-loop-helix (bHLH) family act as proneural genes during early steps nervous system development. Roles bHLH in specifying terminal differentiation postmitotic neurons have been less extensively studied. We analyze here function 5 Caenorhabditis elegans genes, falling into 3 phylogenetically conserved subfamilies, which are continuously expressed a very small number central system. show (a) that 2 orthologs vertebrate bHLHe22/e23 called hlh-17 and hlh-32, redundantly to specify identity single head interneuron class (AUA), well an individual motor neuron (VB2); (b) PTF1a ortholog hlh-13 acts selector control sole octopaminergic C. elegans, RIC; (c) NHLH1/2 hlh-15 controls peptidergic AVK class, known neuropeptidergic signaling hub animal. Strikingly, through null mutant analysis cell-specific rescue experiments, we find loss hlh-15/NHLH resulting abrogation neuropeptide secretion from these causes substantially extended lifespan animal, propose be akin hypothalamic vertebrates. Our functional reveals themes gene complementary earlier lineage specification roles other members. However, such late functions much more sparsely employed by transcription factor family, compared broadly homeodomain family.

Language: Английский

Citations

0
C. elegans wired and wireless connectome: insights into principles of nervous system structure and function DOI
Keertana Venkatesh, Lidia Ripoll-Sánchez, Isabel Beets

et al.

Journal of Biosciences, Journal Year: 2025, Volume and Issue: 50(1)

Published: March 12, 2025

Language: Английский

Citations

0
Food sensing controls C. elegans reproductive behavior by neuromodulatory disinhibition DOI Creative Commons
Yen-Chih Chen,

Kara E Zang,

Hassan Ahamed

et al.

Science Advances, Journal Year: 2025, Volume and Issue: 11(16)

Published: April 16, 2025

Like many organisms, the roundworm Caenorhabditis elegans incorporates an assessment of environmental quality into its reproductive strategy. C. hermaphrodites release fertilized eggs food-rich environments but retain them in absence food. Here, we report discovery a neural circuit required for modulation behavior by food sensing. A mutation that electrically silences AVK interneurons uncouples egg laying from detection cues. We find activity inhibits laying, and AVKs themselves are inhibited dopamine released food-sensing neurons. express large number structurally functionally diverse neuropeptides. Coordination requires subset neuropeptides converge on small ensemble premotor neurons coexpress their cognate receptors. Modulation behavior, therefore, cascade neuromodulatory signals uses disinhibition combinatorial neuropeptide to activate when is sensed.

Language: Английский

Citations

0
Molecular patterns of evolutionary changes throughout the whole nervous system of multiple nematode species DOI Creative Commons
Itai Antoine Toker, Lidia Ripoll-Sánchez, Luke T. Geiger

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 25, 2024

One avenue to better understand brain evolution is map molecular patterns of evolutionary changes in neuronal cell types across entire nervous systems distantly related species. Generating whole-animal single-cell transcriptomes three nematode species from the

Language: Английский

Citations

2
An integrative data-driven model simulating C. elegans brain, body and environment interactions DOI Creative Commons
Mengdi Zhao, Ning Wang, Xinrui Jiang

et al.

Nature Computational Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

The behavior of an organism is influenced by the complex interplay between its brain, body and environment. Existing data-driven models focus on either brain or body–environment. Here we present BAAIWorm, integrative model Caenorhabditis elegans, which consists two submodels: body–environment model. was built multicompartment with realistic morphology, connectome neural population dynamics based experimental data. Simultaneously, used a lifelike three-dimensional physical Through closed-loop interaction submodels, BAAIWorm reproduced zigzag movement toward attractors observed in C. elegans. Leveraging this model, investigated impact system structure both activities behaviors. Consequently, can enhance our understanding how controls to interact surrounding elegans that simulates interactions biophysically detailed neuronal capable replicating species.

Language: Английский

Citations

1