Chemical materials involved in neural tissue engineering scaffold techniques: a narrative review DOI

Miao Li,

Jinhui Zhou,

Yuxiang Ning

et al.

Advanced technology in neuroscience ., Journal Year: 2024, Volume and Issue: 1(2), P. 244 - 260

Published: Nov. 27, 2024

Nerve injury often leads to degeneration or necrosis of damaged nerve cells, which can result in regeneration disorders during the repair process. Promoting is a critical challenge treatment nervous system diseases. With rapid advancements related research, chemical materials have shown significant promise facilitating because their excellent biocompatibility and degradability. The use tissue-engineered material scaffolds provide physical channels for regeneration. These create optimal conditions cell growth migration effectively regulate physiological processes repair. Therefore, wide range applications field This review highlights technological tools available involving materials. (1) Conductive hydrogels: Novel conductive hydrogels been developed by integrating such as graphene, carbon nanotubes, polypyrrole, promote functional recovery cells through electrical stimulation. (2) Three-dimensional printing: printing technology contributes precise control shape, porosity degradation rate scaffolds, providing customized microenvironment (3) Nanomaterials: unique physicochemical properties nanoparticles nanofibers give them great potential penetrate blood‒brain barrier, guide targeted drug delivery. (4) Local release bioactive molecules: Through design materials, controlled molecules factor, brain-derived neurotrophic factor fibroblast has realized, promotes (5) Photothermal photoacoustic stimulation: combination photothermal technologies led development capable responding photostimulation, new avenues noninvasive neurostimulation. engineering are highly effective promoting significantly improve efficiency quality In clinical practice, these techniques expected more strategies patients with injuries, improving function life. also discusses detail different biocompatibility, mechanical strength, degradability, A variety neural tissue scaffold techniques, including provision support, molecules, direct interaction cells. Although show potential, several challenges, long-term stability, individual variation response, large-scale production, still need be addressed before they translated into applications. addition, comprehensive assessment safety efficacy focus future research. Future research will on optimizing conducting trials validate techniques.

Language: Английский

Spatiotemporal Changes in Netrin/Dscam1 Signaling Dictate Axonal Projection Direction in Drosophila Small Ventral Lateral Clock Neurons DOI Creative Commons
Jingjing Liu, Yuedong Wang, Xian Liu

et al.

eLife, Journal Year: 2024, Volume and Issue: 13

Published: May 14, 2024

Axon projection is a spatial- and temporal-specific process in which the growth cone receives environmental signals guiding axons to their final destination. However, mechanisms underlying changes axonal direction without well-defined landmarks remain elusive. Here, we present evidence showcasing dynamic nature of projections Drosophila ’s small ventral lateral clock neurons (s-LNvs). Our findings reveal that these undergo an initial vertical early larval stage, followed by subsequent transition horizontal early-to-mid third instar larvae. The s-LNv correlates with mushroom body calyx expansion, while s-LNv-expressed Down syndrome cell adhesion molecule (Dscam1) interacts Netrins regulate projection. During specific temporal window, locally newborn dorsal secrete Netrins, facilitating s-LNvs. study establishes compelling vivo model probe switching absence clear landmarks. These underscore significance local microenvironments complementary regulation transitions.

Language: Английский

Citations

2
Chemical materials involved in neural tissue engineering scaffold techniques: a narrative review DOI

Miao Li,

Jinhui Zhou,

Yuxiang Ning

et al.

Advanced technology in neuroscience ., Journal Year: 2024, Volume and Issue: 1(2), P. 244 - 260

Published: Nov. 27, 2024

Nerve injury often leads to degeneration or necrosis of damaged nerve cells, which can result in regeneration disorders during the repair process. Promoting is a critical challenge treatment nervous system diseases. With rapid advancements related research, chemical materials have shown significant promise facilitating because their excellent biocompatibility and degradability. The use tissue-engineered material scaffolds provide physical channels for regeneration. These create optimal conditions cell growth migration effectively regulate physiological processes repair. Therefore, wide range applications field This review highlights technological tools available involving materials. (1) Conductive hydrogels: Novel conductive hydrogels been developed by integrating such as graphene, carbon nanotubes, polypyrrole, promote functional recovery cells through electrical stimulation. (2) Three-dimensional printing: printing technology contributes precise control shape, porosity degradation rate scaffolds, providing customized microenvironment (3) Nanomaterials: unique physicochemical properties nanoparticles nanofibers give them great potential penetrate blood‒brain barrier, guide targeted drug delivery. (4) Local release bioactive molecules: Through design materials, controlled molecules factor, brain-derived neurotrophic factor fibroblast has realized, promotes (5) Photothermal photoacoustic stimulation: combination photothermal technologies led development capable responding photostimulation, new avenues noninvasive neurostimulation. engineering are highly effective promoting significantly improve efficiency quality In clinical practice, these techniques expected more strategies patients with injuries, improving function life. also discusses detail different biocompatibility, mechanical strength, degradability, A variety neural tissue scaffold techniques, including provision support, molecules, direct interaction cells. Although show potential, several challenges, long-term stability, individual variation response, large-scale production, still need be addressed before they translated into applications. addition, comprehensive assessment safety efficacy focus future research. Future research will on optimizing conducting trials validate techniques.

Language: Английский

Citations

0