Somatostatin interneurons select dorsomedial striatal representations of the initial learning phase DOI Creative Commons

Sanziana Rotariu,

Gérard Zalcman, Nagham Badreddine

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 28, 2024

ABSTRACT The dorsomedial striatum (DMS) is an associative node involved in the adaptation of ongoing actions to environmental context and initial formation motor sequences. In early or learning phases, DMS activity shows a global decrease neuron firing, eventually giving rise select group active cells, whose number correlated with animal performance. Unveiling how those representation emerge from circuits crucial for understanding plasticity mechanisms adjustments task. Here, we hypothesized that inhibitory microcircuits formed by local interneurons are responsible genesis associated task Despite low density somatostatin (SOM)-positive observed selective manipulation SOM cells disrupted reorganization modulated phases two behavioral contexts. This effect was cell-specific as parvalbumin-positive had no significant effect. Finally, identified high innervation key modulator SPN excitability firing activity. Hence, set pace actively controlling remapping network

Language: Английский

Somatostatin interneurons select dorsomedial striatal representations of the initial motor learning phase DOI Creative Commons

Sanziana Rotariu,

Gisela Zalcman,

Nagham Badreddine

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(5), P. 115670 - 115670

Published: May 1, 2025

Language: Английский

Citations

0
Somatostatin interneurons select dorsomedial striatal representations of the initial learning phase DOI Creative Commons

Sanziana Rotariu,

Gérard Zalcman, Nagham Badreddine

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 28, 2024

ABSTRACT The dorsomedial striatum (DMS) is an associative node involved in the adaptation of ongoing actions to environmental context and initial formation motor sequences. In early or learning phases, DMS activity shows a global decrease neuron firing, eventually giving rise select group active cells, whose number correlated with animal performance. Unveiling how those representation emerge from circuits crucial for understanding plasticity mechanisms adjustments task. Here, we hypothesized that inhibitory microcircuits formed by local interneurons are responsible genesis associated task Despite low density somatostatin (SOM)-positive observed selective manipulation SOM cells disrupted reorganization modulated phases two behavioral contexts. This effect was cell-specific as parvalbumin-positive had no significant effect. Finally, identified high innervation key modulator SPN excitability firing activity. Hence, set pace actively controlling remapping network

Language: Английский

Citations

0