Development of the Motor Periphery is the Rate-Limiting Step in the Ontogeny of the Vestibulo-ocular Reflex DOI Creative Commons
Paige Leary, Celine Bellegarda,

Cheryl Quainoo

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 17, 2024

Vertebrates stabilize gaze using a neural circuit that transforms sensed instability into compensatory counter-rotation of the eyes. Sensory feedback tunes this vestibulo-ocular reflex throughout life. Gaze stabilization matures progressively, either due to similar tuning, or slowly developing component. Here we studied functional development components in larval zebrafish, with and without sensation. Blind fish normally, responses body tilts mature before behavior. Instead, synapses between motor neurons eye muscles timecourse behavioral maturation. Larvae vestibular sensory experience, but whose neuromuscular junction was mature, had strong reflex. Development junction, not determines rate maturation an ancient

Language: Английский

Rethinking sensorimotor circuits DOI Creative Commons
Maarten Zwart

eLife, Journal Year: 2024, Volume and Issue: 13

Published: Nov. 13, 2024

New research shows that the neural circuit responsible for stabilising gaze can develop in absence of motor neurons, contrary to a long-standing model field.

Language: Английский

Citations

1
Development of the Motor Periphery is the Rate-Limiting Step in the Ontogeny of the Vestibulo-ocular Reflex DOI Creative Commons
Paige Leary, Celine Bellegarda,

Cheryl Quainoo

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 17, 2024

Vertebrates stabilize gaze using a neural circuit that transforms sensed instability into compensatory counter-rotation of the eyes. Sensory feedback tunes this vestibulo-ocular reflex throughout life. Gaze stabilization matures progressively, either due to similar tuning, or slowly developing component. Here we studied functional development components in larval zebrafish, with and without sensation. Blind fish normally, responses body tilts mature before behavior. Instead, synapses between motor neurons eye muscles timecourse behavioral maturation. Larvae vestibular sensory experience, but whose neuromuscular junction was mature, had strong reflex. Development junction, not determines rate maturation an ancient

Language: Английский

Citations

0