Quitting Your Day Job in Response to Stress: Cell Survival and Cell Death Require Secondary Cytoplasmic Roles of Cyclin C and Med13 DOI Creative Commons

Johann Bauer,

Thelma Robinson, Randy Strich

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(9), P. 636 - 636

Published: April 25, 2025

Following unfavorable environmental cues, cells reprogram pathways that govern transcription, translation, and protein degradation systems. This reprogramming is essential to restore homeostasis or commit cell death. review focuses on the secondary roles of two nuclear transcriptional regulators, cyclin C Med13, which play key in this decision process. Both proteins are members Mediator kinase module (MKM) complex, which, under normal physiological conditions, positively negatively regulates a subset stress response genes. However, Med13 translocate cytoplasm following death survival interacting with host proteins, respectively. In cytoplasm, required for stress-induced mitochondrial hyperfission promotes regulated pathways. Cytoplasmic stimulates assembly processing bodies (P-bodies) autophagic P-body factors by cargo hitchhiking autophagy. these secondary, a.k.a. "night jobs" outlining importance functions maintaining cellular stress.

Language: Английский

Quitting Your Day Job in Response to Stress: Cell Survival and Cell Death Require Secondary Cytoplasmic Roles of Cyclin C and Med13 DOI Creative Commons

Johann Bauer,

Thelma Robinson, Randy Strich

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(9), P. 636 - 636

Published: April 25, 2025

Following unfavorable environmental cues, cells reprogram pathways that govern transcription, translation, and protein degradation systems. This reprogramming is essential to restore homeostasis or commit cell death. review focuses on the secondary roles of two nuclear transcriptional regulators, cyclin C Med13, which play key in this decision process. Both proteins are members Mediator kinase module (MKM) complex, which, under normal physiological conditions, positively negatively regulates a subset stress response genes. However, Med13 translocate cytoplasm following death survival interacting with host proteins, respectively. In cytoplasm, required for stress-induced mitochondrial hyperfission promotes regulated pathways. Cytoplasmic stimulates assembly processing bodies (P-bodies) autophagic P-body factors by cargo hitchhiking autophagy. these secondary, a.k.a. "night jobs" outlining importance functions maintaining cellular stress.

Language: Английский

Citations

0