Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(3), P. 185 - 185
Published: March 12, 2025
Recently, cannabinoids have gained scientific interest as a promising anti-infective natural product class, reported in several studies. However, the existing knowledge is mainly limited to common like THC and CBD. Therefore, this study aims fill gap by investigating potential of nine selected (both rare cannabinoids): THC, CBD, CBC, CBE, CBF, CBG, CBL, CBN, CBT against Clostridium perfringens Influenza A (H5N1) neuraminidases SARS-CoV-2 main protease spike protein–human ACE2 interaction using standard vitro biochemical enzyme-binding assay. As result, authors’ knowledge, first demonstrate most effect CBG over others its class C. influenza interaction. In comparison CBD were second third candidates. Meanwhile, other derivatives, such CBT, showed at least one effect. Our findings during early drug discovery process indicate cannabinoids, which can be considered for further investigation biological setup.
Language: Английский