Divergent Visuomotor Strategies in Teleosts: Neural Circuit Mechanisms in Zebrafish and Danionella cerebrum DOI Open Access
Kaitlyn E. Fouke, Zichen He, Matthew D. Loring

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 23, 2024

Abstract Many animals respond to sensory cues with species-specific coordinated movements successfully navigate their environment. However, the neural mechanisms that support diverse sensorimotor transformations across species distinct navigational strategies remain largely unexplored. By comparing related teleost species, zebrafish ( Danio rerio, ZF ) and Danionella cerebrum DC ), we investigated behavioral patterns architectures during visually guided optomotor response (OMR). Closed-loop tracking visual stimulation revealed larval employ burst-and-glide locomotion, while display continuous, smooth swimming punctuated sharp directional turns. Although achieve higher average speeds, they lack direction-dependent velocity modulation observed in . Whole-brain two-photon calcium imaging tail head-fixed fish reveals both exhibit direction-selective motion encoding homologous regions, including retinorecipient pretectum, exhibiting fewer binocular, neurons overall. Kinematic analysis of behavior sustain significantly longer directed swim events all stimuli than , highlighting divergent visuomotor strategies, reducing movement duration oblique, turn-inducing stimuli. Lateralized motor-associated activity medial anterior hindbrain suggests a shared circuit motif, circuits independently control vigor direction. These findings highlight diversity among underscored by motifs, establish robust framework for unraveling driving continuous discrete paving way deeper insights into vertebrate functions. Research Highlights Larval faster matching direction motion. execute OMR smooth, curved patterns, interspersed share similar architecture, recruiting pretectal regions. demonstrate lateralized turns, particularly neurons. In Brief global low-angle consistently zebrafish. Fouke et al. use freely moving head fixed reveal an evolutionarily conserved architecture transforming locomotor behaviors. Graphical

Language: Английский

Divergent Visuomotor Strategies in Teleosts: Neural Circuit Mechanisms in Zebrafish and Danionella cerebrum DOI Open Access
Kaitlyn E. Fouke, Zichen He, Matthew D. Loring

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 23, 2024

Abstract Many animals respond to sensory cues with species-specific coordinated movements successfully navigate their environment. However, the neural mechanisms that support diverse sensorimotor transformations across species distinct navigational strategies remain largely unexplored. By comparing related teleost species, zebrafish ( Danio rerio, ZF ) and Danionella cerebrum DC ), we investigated behavioral patterns architectures during visually guided optomotor response (OMR). Closed-loop tracking visual stimulation revealed larval employ burst-and-glide locomotion, while display continuous, smooth swimming punctuated sharp directional turns. Although achieve higher average speeds, they lack direction-dependent velocity modulation observed in . Whole-brain two-photon calcium imaging tail head-fixed fish reveals both exhibit direction-selective motion encoding homologous regions, including retinorecipient pretectum, exhibiting fewer binocular, neurons overall. Kinematic analysis of behavior sustain significantly longer directed swim events all stimuli than , highlighting divergent visuomotor strategies, reducing movement duration oblique, turn-inducing stimuli. Lateralized motor-associated activity medial anterior hindbrain suggests a shared circuit motif, circuits independently control vigor direction. These findings highlight diversity among underscored by motifs, establish robust framework for unraveling driving continuous discrete paving way deeper insights into vertebrate functions. Research Highlights Larval faster matching direction motion. execute OMR smooth, curved patterns, interspersed share similar architecture, recruiting pretectal regions. demonstrate lateralized turns, particularly neurons. In Brief global low-angle consistently zebrafish. Fouke et al. use freely moving head fixed reveal an evolutionarily conserved architecture transforming locomotor behaviors. Graphical

Language: Английский

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