Ih block reveals separation of timescales in pyloric rhythm response to temperature changes in Cancer borealis DOI Creative Commons
Kyra Schapiro, JD Rittenberg, Max Kenngott

et al.

eLife, Journal Year: 2024, Volume and Issue: 13

Published: July 11, 2024

Motor systems operate over a range of frequencies and relative timing (phase). We studied the role hyperpolarization-activated inward current (Ih) in regulating these features pyloric rhythm stomatogastric ganglion (STG) crab, Cancer borealis, as temperature was altered from 11°C to 21°C. Under control conditions, frequency increased monotonically with temperature, while phases dilator (PD), lateral (LP), (PY) neurons remained constant. Blocking Ih cesium (Cs+) phase advanced PD offset, LP onset, offset at 11°C, latter two further increased. In Cs+ increase diminished Q10 dropped ~1.75 ~1.35. Unexpectedly Cs+, dynamics became non-monotonic during transitions; initially increased, then rose once stabilized, creating characteristic 'jag'. Interestingly, jags persisted transitions when pacemaker isolated by picrotoxin, although temperature-induced change recovered levels. Overall, data suggest that plays an important maintaining smooth transitory responses persistent increases different mechanisms circuitry fluctuations.

Language: Английский

Ih block reveals separation of timescales in pyloric rhythm response to temperature changes in Cancer borealis DOI Creative Commons
Kyra Schapiro, JD Rittenberg, Max Kenngott

et al.

eLife, Journal Year: 2024, Volume and Issue: 13

Published: July 11, 2024

Motor systems operate over a range of frequencies and relative timing (phase). We studied the role hyperpolarization-activated inward current (Ih) in regulating these features pyloric rhythm stomatogastric ganglion (STG) crab, Cancer borealis, as temperature was altered from 11°C to 21°C. Under control conditions, frequency increased monotonically with temperature, while phases dilator (PD), lateral (LP), (PY) neurons remained constant. Blocking Ih cesium (Cs+) phase advanced PD offset, LP onset, offset at 11°C, latter two further increased. In Cs+ increase diminished Q10 dropped ~1.75 ~1.35. Unexpectedly Cs+, dynamics became non-monotonic during transitions; initially increased, then rose once stabilized, creating characteristic 'jag'. Interestingly, jags persisted transitions when pacemaker isolated by picrotoxin, although temperature-induced change recovered levels. Overall, data suggest that plays an important maintaining smooth transitory responses persistent increases different mechanisms circuitry fluctuations.

Language: Английский

Citations

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