Three-Dimensionally Printed Microsystems to Facilitate Flow-Based Study of Cells from Neurovascular Barriers of the Retina

Micromachines, Journal Year: 2024, Volume and Issue: 15(9), P. 1103 - 1103

Published: Aug. 30, 2024

Rapid prototyping has produced accessible manufacturing methods that offer faster and more cost-effective ways to develop microscale systems for cellular testing. Commercial 3D printers are now increasingly adapted soft lithography, where elastomers used in tandem with 3D-printed substrates produce vitro cell assays. Newfound abilities prototype have begun expand fundamental bioengineering research the visual system complement tissue engineering studies reliant upon complex microtechnology. This project printing elastomeric devices examined responses of retinal cells flow. Our experiments fabricated molds using metal milling, resin stereolithography, fused deposition modeling via plastic printing. The were connected flow pumps simulate different conditions phenotypic endothelial neural significant neurovascular barriers retina. results indicated microdevices demonstrated differences survival morphology response external barrier function. Modern technology shows great potential rapid production testing will contribute both our understanding development new therapies. Future incorporate varied stimuli as well extracellular matrices expanded subsets cells.

Language: Английский

Editorial commentary on the special issue of immunology and endocrinology

Journal of Biomedical Research, Journal Year: 2024, Volume and Issue: 38, P. 1 - 1

Published: Jan. 1, 2024

Language: Английский