Underlying Mechanisms behind the Brain–Gut–Liver Axis and Metabolic-Associated Fatty Liver Disease (MAFLD): An Update

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3694 - 3694

Published: March 26, 2024

Metabolic-associated fatty liver disease (MAFLD) includes several metabolic dysfunctions caused by dysregulation in the brain–gut–liver axis and, consequently, increases cardiovascular risks and dysfunction. In MAFLD, type 2 diabetes mellitus, obesity, syndrome are frequently present; these conditions related to lipogenesis systemic inflammation. This study aimed review connection between MAFLD. The inflammatory process, cellular alterations hepatocytes stellate cells, hypercaloric diet, sedentarism aggravate prognosis of patients with Thus, understand modulation physiopathology it is necessary include organokines involved this process (adipokines, myokines, osteokines, hepatokines) their clinical relevance project future perspectives condition bring light new possibilities therapeutic approaches. Adipokines responsible for activation distinct signaling different tissues, such as insulin pro-inflammatory cytokines, which important balancing substances avoid MAFLD its progression. Myokines improve quantity quality adipose contributing avoiding development Finally, hepatokines decisive improving or not progression through regulation anti-inflammatory organokines.

Language: Английский

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Extraction and Processing of Bioactive Phytoconstituents from Widely Used South African Medicinal Plants for the Preparation of Effective Traditional Herbal Medicine Products: A Narrative Review

Plants, Journal Year: 2025, Volume and Issue: 14(2), P. 206 - 206

Published: Jan. 13, 2025

Medicinal plants are sources of crude traditional herbal medicines that utilized to reduce the risk of, treat, or manage diseases in most indigenous communities. This is due their potent antioxidant and anti-inflammatory effects. It estimated about 80% population developing countries rely on for healthcare. signifies need medicines, which polyherbal formulations prepared by health practitioners. review examines preparatory steps extract bioactive phytoconstituents post-extraction processes increase potency extracted phytoconstituents. Achieving this will allow reduced use plant materials promote sustainable limited resource medicinal plants, especially our South African context. Electronic ethnobotanical books online databases were used find studies focus phytoconstituent extraction processing enhance Modification synthesize daughter compounds facilitates an enhancement bioavailability. Based data collected through review, importance understanding properties targeted essential selecting required method. determines quality yield

Language: Английский

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Addressing the High and Rising Global Burden of Metabolic Dysfunction‐Associated Steatotic Liver Disease (MASLD) and Metabolic Dysfunction‐Associated Steatohepatitis (MASH): From the Growing Prevalence to Payors' Perspective

Alimentary Pharmacology & Therapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

ABSTRACT Background The continuum of metabolic syndrome encompasses a spectrum dysfunctions impacting obesity‐linked insulin resistance, glucose homeostasis, lipid metabolism and pro‐inflammatory immune responses. global prevalence diseases, including diabetes, chronic liver disease, cardiometabolic disease kidney has surged in recent decades, contributing significantly to population mortality. Metabolic dysfunction‐associated steatotic (MASLD), formerly known as non‐alcoholic fatty is leading cause worldwide. MASLD poses significant health challenge with its rising prevalence, placing substantial burden on healthcare systems, impacts patient well‐being incurs economic costs. Addressing requires comprehensive understanding interconnected factors, implications. Lack awareness, imprecise non‐invasive diagnostic methods ineffective preventive interventions are core components the MASLD‐related problem. Aim aim this article was summarise from payer's perspective. Methods We carried out review MASLD. These topics led discussions insights by an expert panel during 7th Continuum Roundtable meeting, which took place November 2023. This meeting focused burden, patient‐reported outcomes economics, payor societal perspectives, aimed identify opportunities for improving care, optimise resource allocation mitigate overall impact individuals society related During roundtable, emphasis emerged need greater awareness strategic deployment diagnostic, therapeutic preventative measures address effectively. Conclusion high growing. Prioritising prevention dysregulation timely can yield holistic strategy combat MASLD, progression potentially lower Trial Registration: NCT06309992

Language: Английский

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Review and expert opinion on MAFLD, oxidative stress and multifunctional management

Drugs in Context, Journal Year: 2024, Volume and Issue: 13, P. 1 - 11

Published: Jan. 9, 2024

Metabolic-associated fatty-liver disease (MAFLD), previously known as non-alcoholic fatty liver disease, is the most widespread and emerging chronic worldwide, with increasing prevalence rates also in Asia-Pacific region. The has a high socio-economic burden it negatively impacts finances quality of life individuals affected major on healthcare systems. important pathological event MAFLD aetiopathogenesis oxidative stress, which leads to functional structural abnormalities well being involved development other concomitant cardiometabolic diseases. rather complex multisystemic clinical condition involving damage wide spectrum extrahepatic manifestations such obesity, type 2 diabetes, metabolic syndrome cardiovascular This complexity requires cooperation multiple experts identify at an early stage, treat associated comorbidities, promptly refer patient hepatologist when needed. review summarizes current knowledge about reports opinion group southeast Asia region, journey patients developing countries, role stress antioxidant treatment, importance multidisciplinary approach for diagnosis management. article part

Language: Английский

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Impact of Drp1 Loss on Organelle Interaction, Metabolism, and Inflammation in Mouse Liver

Cells, Journal Year: 2025, Volume and Issue: 14(10), P. 679 - 679

Published: May 8, 2025

Dynamin-related protein 1 (Drp1) is a crucial player in mitochondrial fission and liver function. The interactions between mitochondria, endoplasmic reticulum (ER), lipid droplets (LDs) are fundamental for metabolism. This study utilized liver-specific Drp1 knockout (Drp1LiKO) mice to investigate the effects of deficiency on organelle interactions, metabolism, inflammation. Our analysis revealed disrupted mitochondria LDs, as well altered among ER, LDs Drp1LiKO mice. Through mass spectrometry microarray analysis, we identified changes profiles perturbed expression metabolism genes livers Further vitro experiments using primary hepatocytes from confirmed disturbances increased These findings highlight critical involvement regulating efficient overall health. Targeting Drp1-mediated may offer potential developing therapies diseases associated with

Language: Английский

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Association between composite dietary antioxidant index and metabolic dysfunction-associated fatty liver disease: a cross-sectional study from NHANES

BMC Gastroenterology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 19, 2024

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a typical hepatic steatosis with metabolic dysfunction. The composite dietary antioxidant index (CDAI) measures individual capacity, and the relationship MAFLD has received little attention. Our goal to explore association of CDAI MAFLD. Participants were selected from National Health Nutrition Examination Survey (NHANES) 2013 2020. was calculated basing on six antioxidants, including zinc, selenium, carotenoids, vitamins A, C, E. Univariate regression multivariable logistic analysis conducted evaluate correlation between We performed subgroup study in various populations. A total 18,163 participants, 13,969 4,194 non-MAFLD, included. significantly negatively correlated After adjusting for all confounders (including age, gender, race, marital status, poverty ratio, education level, drinking smoking physical activity), individuals highest quartile exhibited 27% lower likelihood developing than those lowest (OR = 0.73; 95% CI [0.66, 0.81], p < 0.001). Physical activity showed that this negative significant moderate-intensity exercise population (Model 3 Q4, OR 0.72; [0.58–0.89], Additionally, changes C independently associated 3, 0.90; [0.86–0.93], found higher scores This provided new reference exploring interventions affect reduce its incidence.

Language: Английский

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A Survey Assessing Nonalcoholic Fatty Liver Disease Knowledge Among Hepatologists and Non‐Hepatologists in China

JGH Open, Journal Year: 2024, Volume and Issue: 8(12)

Published: Dec. 1, 2024

A global increase in nonalcoholic fatty liver disease (NAFLD) prevalence has been observed the last decade. This study assesses knowledge, awareness, and clinical practice gaps of hepatologists non-hepatologists NAFLD management across hospitals China.

Language: Английский

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Effects of Baccharis dracunculifolia DC on an Innovative Animal Model of Cardiometabolic Syndrome

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(11), P. 1446 - 1446

Published: Nov. 12, 2024

Background/Objective: Cardiometabolic syndrome (CMS) is a complex clinical condition that encompasses metabolic dysregulation, cardiovascular disease, and diabetes risk factors. Worldwide, CMS underdiagnosed, its occurrence significantly increases morbimortality. Despite available pharmacological treatments, the approach fragmented, associated conditions are treated independently. This may be partially due to limited preclinical models mimic of CMS. Therefore, our study aims present an innovative animal model cardiometabolic evaluate effects Baccharis dracunculifolia on set alterations with condition. Methods: Female Wistar rats were induced develop diabetes, fed cholesterol-enriched diet, exposed smoke 9 cigarettes/day for 6 weeks. During last 2 weeks, vehicle, B. (30, 100, 300 mg/kg), or combination simvastatin insulin. At end treatment, plasma lipid levels measured, liver was analyzed histologically hepatic quantification oxidative stress assessment. Results: Phytochemical analysis revealed seven phenolic acids six flavonoids in extract. showed significant hepatoprotective effects, reducing AST ALT lowering both levels. The extract also reversed steatosis demonstrated antioxidant properties. Conclusions: These findings suggest therapeutic option dysregulation

Language: Английский

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