Human Exposure to Microplastics and Its Associated Health Risks

Environment & Health, Journal Year: 2023, Volume and Issue: 1(3), P. 139 - 149

Published: Aug. 2, 2023

Microplastics are a globally emerging contaminant in the environment, but little is known about potential risks of microplastics to human health. Possible exposure routes humans include ingestion, inhalation, and dermal penetration, with last these needing equal attention as other two main routes. Evidence showed presence human-derived biological samples (i.e., excrement, biofluids, tissues). Most toxicological studies on were based laboratory rodents cells. Energy homeostasis, intestinal microflora, reproductive, immune, nervous systems regarded targets microplastics. The toxicity microstructures including lysosomes, mitochondria, endoplasmic reticulum, nucleus further revealed health at cellular levels. As carrier, also had magnify contaminants environment (e.g., plasticizer, metals, antibiotics, microorganisms). Studies environmentally realistic conditions still their infancy many unsolved questions predict

Language: Английский

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Microplastics in human samples: Recent advances, hot-spots, and analytical challenges

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 161, P. 117016 - 117016

Published: March 11, 2023

Language: Английский

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Characterization and regulation of microplastic pollution for protecting planetary and human health

Environmental Pollution, Journal Year: 2022, Volume and Issue: 315, P. 120442 - 120442

Published: Oct. 19, 2022

Language: Английский

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Exposure to Polypropylene Microplastics via Oral Ingestion Induces Colonic Apoptosis and Intestinal Barrier Damage through Oxidative Stress and Inflammation in Mice

Toxics, Journal Year: 2023, Volume and Issue: 11(2), P. 127 - 127

Published: Jan. 28, 2023

Extensive environmental pollution by microplastics has increased the risk of human exposure to plastics. However, biosafety polypropylene (PP-MPs), especially PP particles < 10 μm, in mammals not been studied. Thus, here, we explored mechanism action and effect small large PP-MPs, via oral ingestion, on mouse intestinal tract. Male C57BL/6 mice were administered suspensions (8 70 μm; 0.1, 1.0, mg/mL) for 28 days. PP-MP treatment resulted inflammatory pathological damage, ultrastructural changes epithelial cells, imbalance redox system, reactions colon. Additionally, observed damage tight junctions colon decreased mucus secretion ion transporter expression. Further, apoptotic rate colonic cells significantly after treatment. The expression pro-inflammatory pro-apoptosis proteins tissue, while anti-inflammatory anti-apoptosis decreased. In summary, this study demonstrates that PP-MPs induce apoptosis barrier through oxidative stress activation TLR4/NF-κB signal pathway mice, which provides new insights into toxicity MPs mammals.

Language: Английский

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The effect of environmental stressors on growth in fish and its endocrine control

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: March 30, 2023

Fish body growth is a trait of major importance for individual survival and reproduction. It has implications in population, ecology, evolution. Somatic controlled by the GH/IGF endocrine axis influenced nutrition, feeding, reproductive-regulating hormones as well abiotic factors such temperature, oxygen levels, salinity. Global climate change anthropogenic pollutants will modify environmental conditions affecting directly or indirectly fish performance. In present review, we offer an overview somatic its interplay with feeding regulatory summarize effects global warming main on these axes.

Language: Английский

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Radical innovation breakthroughs of biodegradation of plastics by insects: history, present and future perspectives

Frontiers of Environmental Science & Engineering, Journal Year: 2024, Volume and Issue: 18(6)

Published: April 30, 2024

Abstract Insects damaging and penetrating plastic packaged materials has been reported since the 1950s. Radical innovation breakthroughs of biodegradation have initiated discovery plastics by Tenebrio molitor larvae in 2015 followed Galleria mellonella 2017. Here we review updated studies on insect-mediated plastics. Plastic insect larvae, mainly some species darkling beetles (Tenebrionidae) pyralid moths (Pyralidae) is currently a highly active potentially transformative area research. Over past eight years, publications increased explosively, including discoveries ability different to biodegrade plastics, performance, contribution host microbiomes, impacts polymer types their physic-chemical properties, responsible enzymes secreted gut microbes. To date, almost all major polyethylene (PE), polypropylene (PP), polyvinyl chloride (PVC), terephthalate (PET), polyurethane (PUR), polystyrene (PS) can be biodegraded T. ten other representing Tenebrionidae Pyralidae families. The processes are symbiotic reactions or performed synergistic efforts both gut-microbes rapidly depolymerize with hourly half-lives. digestive ezymens bioreagents screted insects play an essential role plasatic certain New research itself, transcriptomes, proteomes metabolomes evaluated mechanisms insects. We conclude this discussing future perspectives

Language: Английский

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Health benefits and health risks of contaminated fish consumption: Current research outputs, research approaches, and perspectives

Heliyon, Journal Year: 2024, Volume and Issue: 10(13), P. e33905 - e33905

Published: July 1, 2024

BackgroundFish contains high-quality omega-3 fatty acids, protein, vitamins, and minerals due to this it is termed as an essential component of a balanced diet. But there have been concerns raised about the risks consuming fish that contaminated with toxins such methylmercury, polychlorinated biphenyls (PCBs), dioxins, pesticides, plastic waste. Consumption containing these pollutants raising global mortality morbidity rates.Scope approachesThe review examines current research outputs on health benefits potential consumption. The also discusses various approaches mitigating problems caused by consumption, highlights roles balancing when fish.Key findings conclusionDifferent indicated contaminants cause cancer, kidney failure, adverse neurological effect, cardiovascular diseases, so vulnerable groups pregnant, child breast-feeding children. In conclusion, need get more tangible evidence advantages disadvantages consumption safeguard wellbeing society.

Language: Английский

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Tracing microplastics in marine fish: Ecological threats and human exposure in the Bay of Bengal

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 963, P. 178462 - 178462

Published: Jan. 20, 2025

Language: Английский

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Impact of Micro- and Nanoplastics on Mitochondria

Metabolites, Journal Year: 2022, Volume and Issue: 12(10), P. 897 - 897

Published: Sept. 23, 2022

Mitochondria are highly dynamic cellular organelles that perform crucial functions such as respiration, energy production, metabolism, and cell fate decisions. Mitochondrial damage dysfunction critically lead to the pathogenesis of various diseases including cancer, diabetes, neurodegenerative cardiovascular disorders. in response environmental contaminant exposure its association with has also been reported. Recently, persistent pollutants, micro- nanoplastics, have become growing global threats potential health risks. In this review, we discuss impact nanoplastics on mitochondria review current knowledge field.

Language: Английский

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Can microplastics threaten plant productivity and fruit quality? Insights from Micro-Tom and Micro-PET/PVC

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 895, P. 165119 - 165119

Published: June 24, 2023

Solanum lycopersicum L., a crop grown worldwide with high nutritional value for the human diet, was used to test impact of microplastics on plant growth, productivity, and fruit quality. Two most represented in soils, polyethylene terephthalate (PET) polyvinyl chloride (PVC), were tested. Plants pots an environmentally realistic concentration and, during whole life cycle, photosynthetic parameters, number flowers fruits monitored. At end cultivation, biometry ionome evaluated, along production Both pollutants had negligible effects shoot traits, only PVC causing significant reduction fresh weight. Despite apparent low or no toxicity vegetative stage, both decreased case PVC, also their weights. The plastic polymer-induced decline coupled wide variations ionome, marked increases Ni Cd. By contrast there nutritionally valuable lycopene, total soluble solids, phenols. Altogether, our results reveal that can not limit productivity but negatively quality enhance food safety hazards, thus raising concerns potential health risks humans.

Language: Английский

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