Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 20, 2024
N6-methyladenosine
is
one
of
the
most
common
and
reversible
post-transcriptional
modifications
in
eukaryotes,
it
involved
alternative
splicing
RNA
transcription,
degradation,
translation.
It
well
known
that
cancer
cells
acquire
energy
through
metabolic
reprogramming
to
exhibit
various
biological
behaviors.
Moreover,
numerous
studies
have
demonstrated
m6A
induces
by
regulating
expression
core
genes
or
activating
signaling
pathways.
Meanwhile,
related
regulators
are
key
targets
regulation
immune
effects.
We
further
summarize
how
contribute
tumor
metabolism,
these
events
affect
microenvironment,
with
a
specific
focus
on
different
cell
types.
Finally,
we
applications
this
field
immunotherapy.
review
potential
role
microenvironment
its
regulatory
mechanism,
aim
providing
new
for
Discover Oncology,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: Dec. 20, 2023
RNA
modification
is
a
post-transcriptional
level
of
regulation
that
widely
distributed
in
all
types
RNAs,
including
mRNA,
tRNA,
rRNA,
miRNA,
and
lncRNA,
where
N6-methyladenine
(m6A)
the
most
abundant
mRNA
methylation
modification.
Significant
evidence
has
depicted
m6A
modifications
are
closely
related
to
human
diseases,
especially
cancer,
play
pivotal
roles
transcription,
splicing,
stabilization,
translation
processes.
The
common
urological
cancers
include
prostate,
bladder,
kidney,
testicular
cancers,
accounting
for
certain
proportion
with
an
ever-increasing
incidence
mortality.
recurrence,
systemic
metastasis,
poor
prognosis,
drug
resistance
urologic
tumors
have
prompted
identification
new
therapeutic
targets
mechanisms.
Research
on
may
provide
solutions
current
puzzles.
In
this
review,
we
comprehensive
overview
key
played
by
modifications,
as
well
recent
research
advances
diagnostics
molecularly
targeted
therapies.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 20, 2024
N6-methyladenosine
is
one
of
the
most
common
and
reversible
post-transcriptional
modifications
in
eukaryotes,
it
involved
alternative
splicing
RNA
transcription,
degradation,
translation.
It
well
known
that
cancer
cells
acquire
energy
through
metabolic
reprogramming
to
exhibit
various
biological
behaviors.
Moreover,
numerous
studies
have
demonstrated
m6A
induces
by
regulating
expression
core
genes
or
activating
signaling
pathways.
Meanwhile,
related
regulators
are
key
targets
regulation
immune
effects.
We
further
summarize
how
contribute
tumor
metabolism,
these
events
affect
microenvironment,
with
a
specific
focus
on
different
cell
types.
Finally,
we
applications
this
field
immunotherapy.
review
potential
role
microenvironment
its
regulatory
mechanism,
aim
providing
new
for
