Development of a general anti-viral therapeutic using cholestosome technology to exploit inhibition of intracellular viral production

Biochemistry and Biophysics Reports, Journal Year: 2025, Volume and Issue: 41, P. 101922 - 101922

Published: Jan. 23, 2025

Language: Английский

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Molecular Functions and Potential Utilization of Zinc Finger Proteins in Protozoan Parasites

Published: April 10, 2025

Zinc finger proteins (ZFP) are metalloproteins whose zinc atom interacts with side chains of specific histidines and cysteines the motif, generating functional three dimensional structures. A good number these from different species similar while others divergent in structure function. Existing literature on structural features, functions their potential to be targeted for drug development or used as molecular tools parasitic protozoa was explored. Evidence reviewed articles revealed that, just like other eukaryotes, function various parasite cellular processes such as: transcription, RNA editing, mRNA processing & export and, turn-over among others. Some them had same features homologues eukaryotes including hosts. However, there were which studies aiming at replacing reported positive results some parasites Giardia lamblia, Trichomonas vaginalis Leishmania donovani though this is promising, off- target challenge that can cause effects, must solved before wide application achieved. Successful engineering use genome editing also Plasmodium falciparum. Since nucleases a powerful research medical tool, repurposing ZFPs useful therapy discovery. For succeed, more knowledge how regulated needed.

Language: Английский

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Foot-and-mouth disease virus (FMDV) negatively regulates ZFP36 protein expression to alleviate its antiviral activity

Journal of Virology, Journal Year: 2024, Volume and Issue: 98(9)

Published: Aug. 28, 2024

Zinc finger protein 36 (ZFP36) is a key regulator of inflammatory and cytokine production. However, the interplay between swine zinc-finger (sZFP36) foot-and-mouth disease virus (FMDV) has not yet been reported. Here, we demonstrate that overexpression sZFP36 restricted FMDV replication, while knockdown facilitated replication. To subvert antagonism sZFP36, decreased expression through its non-structural 3C protease (3C

Language: Английский

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Editorial: Advances in host-pathogen interactions for diseases in animals and birds

Frontiers in Veterinary Science, Journal Year: 2023, Volume and Issue: 10

Published: Sept. 11, 2023

EDITORIAL article Front. Vet. Sci., 11 September 2023Sec. Veterinary Infectious Diseases Volume 10 - 2023 | https://doi.org/10.3389/fvets.2023.1282110

Language: Английский

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