Clinical characteristics and outcomes of elderly COVID-19 patients admitted to ICU during Chinese Mainland’s Omicron Wave: A multicenter retrospective cohort study DOI Creative Commons
Ziying Chen, Linna Huang, Qi Zhang

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 24, 2023

Abstract Background: There is limited information on elderly patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant infections. We aimed to describe the characteristics and outcomes of infections admitted intensive care unit (ICU) Chinese Mainland evaluate risk factors associated mortality in these patients. Methods: conducted a multicenter retrospective study including SARS-CoV-2 infection who were ICU from November 1, 2022, February 11, 2023, Mainland. The primary objective was secondary for Results: included 1605 aged 65 years or older diagnosed critical COVID-19 ICUs 59 hospitals across different areas median age 78 (IQR 72–84), male accounting 1164/1605 (72.5%), 1459/1605 (90.9%) having at least one comorbidity. APACHE II scores SOFA 16 11–23) 5 3–8), respectively. Among patients, 553 (34.5%) recovery discharged, 557 (34.7%) died ICUs, 495 (30.8%) discharged voluntarily during therapy later confirmed dead after discharge. Multivariable logistics analysis indicated that age, coinfection, high levels white blood cell count, urea nitrogen, D-Dimer, lactate admission against discharged. Conclusions: Elderly infected had considerable rate. Better understanding may improve clinical management more rational allocation medical resources surge.

Language: Английский

A meta-meta-analysis of co-infection, secondary infections, and antimicrobial resistance in COVID-19 patients DOI Creative Commons
Shuaibu Suleiman Adeiza, Md. Aminul Islam,

Mir Salma Akter

et al.

Journal of Infection and Public Health, Journal Year: 2023, Volume and Issue: 16(10), P. 1562 - 1590

Published: July 18, 2023

The newly discovered coronavirus SARS-CoV-2 has sparked a worldwide pandemic of COVID-19, which caused havoc on medical infrastructures, economies, and cultures around the world. Determining whole scenario is essential since variants sub-variants keep appearing after vaccinations booster doses. objective this secondary meta-analysis to analysis co-infection, infections, antimicrobial resistance (AMR) in COVID-19 patients. This study used five significant databases conduct systematic review an overlap evaluate pooled estimates co-infections infections. summary showed overall co-infection effect 26.19% (95% confidence intervals CI: 21.39 31.01, I2=98.78, n = 14 meta-analysis) among patients with COVID-19. A coinfection 11.13% 9.7 12.56, I2=99.14, 11 for bacteria; 9.69% 1.21 7.90, I2 =98.33) fungal 3.48% 2.15 4.81, =95.84) viruses. infection 19.03% 9.53 28.54, =85.65) was from 2 meta-analyses (Ave: 82 primary studies). first that compiles results all previous three years into single source offers strong proof infections Early detection AMR crucial order effectively effective treatment.

Language: Английский

Citations

24
Acinetobacter baumannii Bloodstream Infections in the COVID-19 Era: A Comparative Analysis between COVID-19 and Non-COVID-19 Critically Ill Patients DOI Creative Commons
Ioannis Andrianopoulos,

Theodora Maniatopoulou,

Nikolaos Lagos

et al.

Microorganisms, Journal Year: 2023, Volume and Issue: 11(7), P. 1811 - 1811

Published: July 14, 2023

The coronavirus disease (COVID-19) pandemic increased the incidence of severe infections caused by multidrug-resistant (MDR) pathogens among critically ill patients, such as Acinetobacter baumannii (AB), whose bloodstream (BSIs) have been associated with significant mortality. Whether there is any difference in outcome between COVID-19 and non-COVID-19 patients AB BSI still remains unknown. We conducted a retrospective study comparing clinical characteristics outcomes versus BSI. Overall, 133 (102 COVID-19, 31 non-COVID-19) were studied. 28-day mortality rate was high did not differ significantly (69.6% vs. 61.3% non-COVID-19, p = 0.275). Patients septic shock had higher irrespective their status majority deaths occurring during first 7 days. more likely to ventilator-associated pneumonia (VAP) source (55.8% 22.3%, respectively, 0.0001) develop acute respiratory distress syndrome (ARDS) (78.4% 48.4%, 0.001), sepsis (86.3% 67.7%, 0.03), (88.3% 58.1%, 0.007) compared patient group. In conclusion, A. often shock, while VAP main origin

Language: Английский

Citations

10
Frontiers in superbug management: innovating approaches to combat antimicrobial resistance DOI
Priyanka Chambial, Neelam Thakur, Prudhvi Lal Bhukya

et al.

Archives of Microbiology, Journal Year: 2025, Volume and Issue: 207(3)

Published: Feb. 14, 2025

Language: Английский

Citations

0
Clinical and microbiological characteristics of viral-bacterial pneumonia caused by Klebsiella pneumoniae in SARS-CoV-2 infected patients DOI Open Access
К. В. Левченко, В. М. Мицура, D. V. Tapalski

et al.

Proceedings of the National Academy of Sciences of Belarus Medical series, Journal Year: 2025, Volume and Issue: 22(1), P. 17 - 25

Published: Feb. 27, 2025

The object of study was to investigate the clinical and laboratory characteristics, outcomes disease, susceptibility antibiotics different combinations in patients with pneumonia caused by K. pneumoniae associated not COVID-19. We analysed 93 cases detected biological materials including 65 ones COVID-19 28 without In both groups, diseases circulatory system metabolic disorders were most common concomitant conditions. data statistically different. lethal found reliably more often (66 % vs 32 %). predominantly after tenth day admission hospital (nosocomial strains). majority strains had a multiple resistance antibiotics. no colistin demonstrated low efficacy, those carbapenems. A proportion 40 (61.5 (48.6–73.3) %) samples isolated from carbopenemases detected. results refer preferability comprising schemes for treatment

Language: Английский

Citations

0
Co-Infection of SARS-CoV-2 and Klebsiella pneumoniae: A Systematic Review and Meta-Analysis DOI Creative Commons
Angélica de Lima das Chagas, Joilma Cruz da Silva Araújo, Jaqueline Correia Pontes

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(11), P. 1149 - 1149

Published: May 30, 2024

The study aimed to assess the prevalence of COVID-19 and

Language: Английский

Citations

2
Identifikasi Bakteri Dari Sampel Darah Pasien COVID-19 Di RSUD Ciawi Kabupaten Bogor DOI Creative Commons

Wulan Fitriani Safari,

Sri Wardhiati,

Almatin Puspa Dewi

et al.

Journal of Medical Laboratory Research, Journal Year: 2024, Volume and Issue: 2(2), P. 12 - 17

Published: June 21, 2024

Coronavirus Disease 2019 (COVID-19) is a disease caused by the Severe Acute Respiratory Syndrome Corona Virus 2 virus called SARSCov-2, this attacks respiratory tract and creates risk of infection in COVID-19 patients. Bacterial infections are known to complicate viral associated with worsening conditions The aim research identify bacteria from blood samples patients at Ciawi Hospital, Bogor Regency. This type quantitative descriptive which describes types study were who confirmed (PCR) positive for underwent culture microbiology examinations Regional Hospital. Data collection was carried out using documentation method. results showed that 243 examination, 63 results. In samples, 51 (80.9%) found Gram consisting of: S. hominis, haemolyticus, epidermidis, cohnii ureal, aureus, warneri E. faecalis. There 12 Negative (19.1%) A. baumannii, coli, Pseudomonas sp, K. pneumoniae, paucimobilis aerogenes.

Language: Английский

Citations

0
Clinical guideline highlights for the hospitalist: Management of COVID‐19 DOI Creative Commons
Stephanie Thomas, Danielle L. Clark

Journal of Hospital Medicine, Journal Year: 2024, Volume and Issue: 19(10), P. 931 - 933

Published: June 30, 2024

GUIDELINE TITLE : 2023 IDSA Guidelines on the Treatment and Management of Patients with COVID‐19 RELEASE DATE 06/26/2023 PRIOR VERSION (S) 2021 DEVELOPER Infectious Diseases Society America FUNDING SOURCE TARGET POPULATION Infection

Language: Английский

Citations

0
Epidemiology of Covid-19 DOI Open Access
Serge Aho

Published: July 13, 2023

We provide a summary of various epidemiological parameters related to COVID-19 such as incubation period, serial interval and other parameters. Understanding these is important for developing prevention strategies. SARS-CoV-2 can be transmitted by droplets close contact, but there evidence airborne transmission. Aerosol-generating procedures have been identified one the specific risk factors healthcare workers. Super-spreading events refer situations where small number individuals cause majority infections. The basic reproductive (R0) spread parameter (k) are used characterise transmissibility disease. Estimated values R0 range from 2 3 estimated value k 0.1.The duration infectiousness depends on viral load shedding. Viral varies according clinical spectrum, type variant vaccination status. relationship between infectivity not fully understood.With regard frequency symptoms signs COVID-19, fever, cough, fatigue dyspnoea common. prevalence olfactory gustatory dysfunction (OGD) studies countries. Age comorbidities associated with dysfunction.Estimates proportion asymptomatic patients 6% 96%. Asymptomatic transmission considered likely control measures.We reviewed quantitative semiology reported sensitivity, specificity likelihood ratios signs.Finally, we also review (including health care workers), co-infections, epidemiology variants..

Language: Английский

Citations

1
To prescribe or not: a two-center retrospective observational study of antibiotics usage and outcomes of COVID-19 in Turkey DOI Creative Commons
Hanife Nur Karakoç, Merve Aydın,

Safiye Nur Ozcan

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 9, 2024

This retrospective cohort study conducted in Turkey between December 2020 and June 2022 aimed to assess antibiotic use, bacterial co-infections, the associated factors on mortality hospitalized patients with mild-to-severe COVID-19. Among 445 patients, 80% received antibiotics, fluoroquinolones being most common choice, followed by beta-lactams combinations. Various clinical laboratory parameters, including symptoms, comorbidities, CCI, oxygen requirements, CRP levels were observed be elevated group. Non-survivors had more ICU admissions longer hospital stays compared survivors. We a multivariate Cox regression analysis evaluate related mortality. However, we did not find an association use [HR 2.7 (95% CI 0.4-20)]. The identified significant prescription, such as CCI (OR 1.6), 2.3), admission 8.8), (p < 0.05). findings suggest re-evaluating necessity of antibiotics COVID-19 cases based assessments, focusing presence infections rather than empirical treatment. Further research is necessary accurately identify co-infections who would benefit from

Language: Английский

Citations

0
Community-acquired pneumonia: antibiotic therapy approach after the COVID-19 pandemic. A review DOI Creative Commons
A. A. Zaytsev, Guchev Ia

Consilium Medicum, Journal Year: 2023, Volume and Issue: 25(9), P. 581 - 588

Published: Oct. 14, 2023

Pneumonia is clearly differentiated from other focal inflammatory lung diseases of non-infectious origin. A patient with community-acquired pneumonia (CAP) should receive antibacterial drugs no later than 4 hours after the diagnosis. Initial therapy in CAP be based on factors affecting potential causative agents and risk drug-resistant microorganisms. Rational use amoxicillin terms dose frequency patients without severe comorbidities for PES pathogens, -lactam combination a macrolide or moxifloxacin monotherapy high-risk groups most effective strategy empirical therapy.

Language: Английский

Citations

0