Dysregulation of sphingolipid metabolism in liver fibrosis DOI Open Access
Nan Wu, Meiyi Song, Fan Zhang

et al.

Metabolism and Target Organ Damage, Journal Year: 2024, Volume and Issue: 4(4)

Published: Sept. 14, 2024

The dysregulation of sphingolipid metabolism emerges as a pivotal factor in the development and progression liver fibrosis, condition marked by overproduction buildup extracellular matrix proteins that can lead to cirrhosis failure. Sphingolipids, diverse class lipids essential for cellular structure signaling, are integral numerous biological functions such proliferation, morphological differentiation, programmed cell death. In context changes have been associated with activation hepatic stellate cells, primary cells responsible fibrogenesis liver. These metabolic disruptions an imbalance between profibrotic antifibrotic sphingolipids, notably sphingosine-1-phosphate ceramide, contributing pathophysiological mechanisms drive fibrosis. intricate relationship fibrotic pathways underscores potential targeting enzymes receptors therapeutic strategies mitigate core this review delves into how contribute exploring biomarkers targets. Challenges research future directions comprehensively understanding roles fibrosis discussed, aiming open new intervention.

Language: Английский

Bile acids regulation of cellular stress responses in liver physiology and diseases DOI Creative Commons
Tiangang Li, Mohammad Nazmul Hasan, Lijie Gu

et al.

eGastroenterology, Journal Year: 2024, Volume and Issue: 2(2), P. e100074 - e100074

Published: May 1, 2024

Bile acids are physiological detergents and signalling molecules that critically implicated in liver health diseases. Dysregulation of bile acid homeostasis alters cell function causes injury chronic Therapeutic agents targeting synthesis, transport hold great potential for treatment The broad cellular impacts pharmacological manipulations metabolism still incompletely understood. Recent research has discovered new links to the regulation autophagy lysosome biology, redox endoplasmic reticulum stress. These well-conserved mechanisms allow cells adapt nutrient organelle stresses play critical roles maintaining integrity promoting survival. However, dysregulation these pathways is often observed diseases, which exacerbates dysfunction contribute disease pathogenesis. Therefore, identification novel significantly advanced our knowledge biology physiology, needed understand contributions pathogenesis, establish as diagnostic markers develop acid-based interventions. In this review, we will first discuss pathogenesis then recent findings on crosstalk stress responses. Future investigations better define crosstalks regulating processes.

Language: Английский

Citations

7
The efficacy of platelet-derived extracellular vesicles in the treatment of diabetic wounds: a systematic review and meta-analysis of animal studies DOI

Zhi Cai,

Yuhan Wang, Shan Hu

et al.

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: Jan. 15, 2025

Language: Английский

Citations

0
Regulatory role of S1P and its receptors in sepsis-induced liver injury DOI Creative Commons
Bin Wang, Xiaoyu Wu,

Cheng Jiang-feng

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 28, 2025

As an immune and metabolic organ, the liver affects progression prognosis of sepsis. Despite severe adverse effects sepsis injury on body, treatment options remain limited. Sphingosine-1-phosphate (S1P) is a widely distributed lipid signaling molecule that binds to five sphingosine-1-phosphate receptors (S1PR) regulate downstream pathways involved in pathophysiological processes sepsis, including endothelial permeability, cytokine release, vascular tone. This review summarizes current research role S1P normal biology describes mechanisms by which changes S1P/S1PR affect development liver-related diseases. At same time, pathological underlying injury, as evidenced clinical manifestations during were comprehensively reviewed. paper focused mechanistic through its modulate immunity, bile acid metabolism, liver-intestinal circulation septic injury. Finally, relationships between with inflammation metabolism use related drugs for examined. By elucidating receptor pathogenesis this established molecular targeting framework, providing novel insights into drug development.

Language: Английский

Citations

0
Bile Acid Signaling in Metabolic and Inflammatory Diseases and Drug Development DOI
Tiangang Li, John Y.L. Chiang

Pharmacological Reviews, Journal Year: 2024, Volume and Issue: 76(6), P. 1221 - 1253

Published: July 8, 2024

Bile acids are the end products of cholesterol catabolism. Hepatic bile acid synthesis accounts for a major fraction daily turnover in humans. Biliary secretion generates flow and facilitates biliary lipids, endogenous metabolites, xenobiotics. In intestine, facilitate digestion absorption dietary lipids fat-soluble vitamins. Through activation nuclear receptors G protein-coupled interaction with gut microbiome, critically regulate host metabolism innate adaptive immunity involved pathogenesis cholestasis, metabolic dysfunction-associated steatotic liver disease, alcohol-associated type-2 diabetes, inflammatory bowel diseases. their derivatives have been developed as potential therapeutic agents treating chronic diseases gastrointestinal disorders. SIGNIFICANCE STATEMENT: solubilization lipid absorption, immunity, modulate microbiome. Targeting signaling holds promise

Language: Английский

Citations

3
Multi-omics reveals the alleviating effect of berberine on ulcerative colitis through modulating the gut microbiome and bile acid metabolism in the gut-liver axis DOI Creative Commons
Jingsheng Yu,

Yixuan Zheng,

Changmin Liu

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 24, 2024

The dysfunction of gut microbiome and bile acid metabolism might cause the incidence relapse ulcerative colitis (UC). Thus, natural products have been considered effective for UC through regulation acid. In this study, we evaluated regulatory effect berberine on in UC. Results showed that relative abundances beneficial bacteria a decreasing trend model, taurine conjugated acids increased from liver tissue to colon tissue. Berberine inhibited colonization harmful promoted primary metabolism. Moreover, used multi-omics technology (metagenomics, metabolomics, transcriptomics technology) reveal restored intestinal barrier function acid/S1PR2/RhoA/ROCK pathway. result transmission electron microscopy directly damaged mucosal was repaired treatment. This study revealed treatment influence

Language: Английский

Citations

2
Dysregulation of sphingolipid metabolism in liver fibrosis DOI Open Access
Nan Wu, Meiyi Song, Fan Zhang

et al.

Metabolism and Target Organ Damage, Journal Year: 2024, Volume and Issue: 4(4)

Published: Sept. 14, 2024

The dysregulation of sphingolipid metabolism emerges as a pivotal factor in the development and progression liver fibrosis, condition marked by overproduction buildup extracellular matrix proteins that can lead to cirrhosis failure. Sphingolipids, diverse class lipids essential for cellular structure signaling, are integral numerous biological functions such proliferation, morphological differentiation, programmed cell death. In context changes have been associated with activation hepatic stellate cells, primary cells responsible fibrogenesis liver. These metabolic disruptions an imbalance between profibrotic antifibrotic sphingolipids, notably sphingosine-1-phosphate ceramide, contributing pathophysiological mechanisms drive fibrosis. intricate relationship fibrotic pathways underscores potential targeting enzymes receptors therapeutic strategies mitigate core this review delves into how contribute exploring biomarkers targets. Challenges research future directions comprehensively understanding roles fibrosis discussed, aiming open new intervention.

Language: Английский

Citations

0