Volatile oil of Acori tatarinowii rhizoma: potential candidate drugs for mitigating dementia

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 23, 2025

This study aims to elucidate the mitigating effects of volatile oil Acori tatarinowii rhizoma (ATR) on dementia, in order provide a reference for future research and applications ATR field dementia. A search strategy was developed using terms such as "Acori rhizoma," "Acorus Schott," "Asarone," "Dementia." The literature conducted PubMed, Web Science, Google Scholar, studies not meeting inclusion criteria were excluded. summarizes main metabolites, active ingredients, toxicological properties, pharmacokinetic characteristics from with particular focus its potential mechanisms action. Furthermore, highlights limitations existing offers insights into directions. mitigates dementia through multiple pathways, including reducing abnormal protein aggregation, promoting neurogenesis, inhibiting neuronal apoptosis, regulating neurotransmitters, improving synaptic function, modulating autophagy, countering cellular stress, neuroinflammation, alleviating vascular risk factors. multi-pathway pharmacological are well-aligned complex progression, highlighting significant therapeutic anti-dementia applications. provides new perspectives development more effective drugs. Nonetheless, further rigorous high-quality preclinical clinical investigations required address key issues, chemical characterization ATR, synergistic among toxicity profiles, definitive efficacy.

Language: Английский

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Clinical Applications and Modern Pharmacological Studies on <i>Acorus </i><i>tatarrinowii</i> Schott

Traditional Chinese Medicine, Journal Year: 2024, Volume and Issue: 13(10), P. 2592 - 2599

Published: Jan. 1, 2024

Language: Английский

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