Decoding the heterogeneous subpopulations of glioblastoma for prognostic stratification and uncovering the promalignant role of PSMC2

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 17, 2025

Language: Английский

Machine learning-based in-silico analysis identifies signatures of lysyl oxidases for prognostic and therapeutic response prediction in cancer

Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 5, 2025

Abstract Background Lysyl oxidases (LOX/LOXL1-4) are crucial for cancer progression, yet their transcriptional regulation, potential therapeutic targeting, prognostic value and involvement in immune regulation remain poorly understood. This study comprehensively evaluates LOX/LOXL expression highlights types where targeting these enzymes developing LOX/LOXL-based models could have significant clinical relevance. Methods We assessed the association of with survival drug sensitivity via analyzing public datasets (including bulk single-cell RNA sequencing data six from Gene Expression Omnibus (GEO), Chinese Glioma Genome Atlas (CGGA) Cancer Program (TCGA)). performed comprehensive machine learning-based bioinformatics analyses, including unsupervised consensus clustering, a total 10 machine-learning algorithms prediction Connectivity map tool prediction. Results The significance family was evaluated across 33 types. Overexpression showed strong correlation tumor progression poor survival, particularly glioma. Therefore, we developed novel model glioma by integrating its co-expressed genes. highly predictive overall patients, indicating utility assessment. Furthermore, our analysis uncovered distinct LOXL2-overexpressing malignant cell population recurrent glioma, characterized activation collagen, laminin, semaphorin-3 pathways, along enhanced epithelial-mesenchymal transition. Apart revealed role LOXL3 overexpression macrophages predicting response to checkpoint blockade bladder renal cancers. Given pro-tumor genes most analyzed cancers, identified compounds, such as VEGFR inhibitor cediranib, target pan-LOX/LOXL cancer. Conclusions Our provides insights into pathogenesis treatment,

Language: Английский

Ferroptosis in hepatocellular carcinoma: Mechanisms and therapeutic implications

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 182, P. 117769 - 117769

Published: Dec. 16, 2024

Language: Английский