Metal–organic frameworks in drug delivery: engineering versatile platforms for therapeutic applications
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(41), P. 30201 - 30229
Published: Jan. 1, 2024
Recently,
metal-organic
frameworks
(MOFs)
have
attracted
much
attention
as
versatile
materials
for
drug
delivery
and
personalized
medicine.
MOFs
are
porous
structures
made
up
of
metal
ions
coupled
with
organic
ligands.
This
review
highlights
the
synthesis
techniques
used
to
design
specific
features
such
surface
area
pore
size,
encapsulation
within
not
only
improves
their
stability
solubility
but
also
allows
controlled
release
kinetics,
which
therapeutic
efficacy
minimizes
adverse
effects.
Furthermore,
it
discusses
challenges
potential
advantages
MOF-based
delivery,
MOF
stability,
biocompatibility,
scale-up
production.
With
further
advancements
in
synthesis,
functionalization
techniques,
understanding
interactions
using
biological
systems,
can
significant
promise
expanding
medicine
improving
patient
outcomes.
Language: Английский
Characterization of a purified novel Aureobasidium pullulans NAC8 lipase and covalent-immobilization for use in the biodegradation of oil-contaminated wastewater
International Journal of Biological Macromolecules,
Journal Year:
2025,
Volume and Issue:
unknown, P. 140781 - 140781
Published: Feb. 1, 2025
Language: Английский
Green chemistry: Modern therapies using nanocarriers for treating rare brain cancer metastasis from colon cancer
SLAS DISCOVERY,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100213 - 100213
Published: Jan. 1, 2025
Brain
metastasis
(BM)
from
colon
cancer
is
associated
with
a
poor
prognosis
and
restricted
treatment
alternatives,
largely
due
to
issues
related
blood-brain
barrier
(BBB)
permeability
the
negative
effects
of
standard
chemotherapy.
Nanotechnology
improves
efficacy
by
enabling
targeted
controlled
drug
delivery.
This
review
article
evaluates
potential
nanotechnology-based
therapies
for
treating
BM,
emphasizing
their
capacity
cross
BBB,
diminish
metastatic
growth,
enhance
overall
survival
rates.
A
multiple
studies
evaluated
nanoparticles
(NPs)
as
carriers
chemotherapy,
focusing
on
parameters
including
particle
size,
surface
charge,
drug-loading
capacity.
The
study
also
reviewed
that
examined
BBB
penetration,
in
vitro
tumor
accumulation,
vivo
growth
inhibition.
In
findings
indicated
NPs
accumulate
more
efficiently
BM
tissue
than
healthy
brain
show
significant
penetration.
vivo,
nanotherapy
markedly
inhibited
prolonged
relative
conventional
chemotherapy
or
control
treatments
while
exhibiting
reduced
side
effects.
Recent
demonstrated
plant
extracts
can
effectively
safely
synthesize
nanomaterials,
positioning
them
viable
environmentally
friendly
precursor
nanomaterial
production.
Nanotechnology-based
demonstrate
minimizing
systemic
toxicity,
enhancing
therapeutic
efficacy,
facilitating
Further
research
required
confirm
these
implement
clinical
practice.
Language: Английский
Magnetizing Biotech–Advances in (In Vivo) Magnetic Enzyme Immobilization
Engineering in Life Sciences,
Journal Year:
2025,
Volume and Issue:
25(3)
Published: March 1, 2025
ABSTRACT
Industrial
biocatalysis,
a
multibillion
dollar
industry,
relies
on
the
selectivity
and
efficacy
of
enzymes
for
efficient
chemical
transformations.
However,
enzymes,
evolutionary
adapted
to
mild
biological
conditions,
often
struggle
in
industrial
processes
that
require
harsh
reaction
resulting
reduced
stability
activity.
Enzyme
immobilization,
which
addresses
challenges
such
as
enzyme
reuse
stability,
has
therefore
become
vital
strategy
improving
use
applications.
Traditional
immobilization
techniques
rely
confinement
or
display
within/on
organic
inorganic
supports,
while
recent
advances
synthetic
biology
have
led
development
solely
vivo
methods
streamline
production
immobilization.
These
offer
added
benefits
terms
sustainability
cost
efficiency.
In
addition,
multifunctional
materials,
magnetic
(nano)materials
enabled
improved
separation
purification
processes.
The
combination
both
“worlds,”
opens
up
new
avenues
(industrial)
fundamental
science,
biomedicine.
Therefore,
this
review,
we
provide
an
overview
established
recently
emerging
generation
protein
immobilizates,
placing
special
focus
solutions.
Language: Английский
Self-assembled Immobilization and Metal-Polyphenol Network Encapsulation of β-Galactosidase on T4 phage for Enhanced Biocatalytic Performance.
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 18, 2025
Abstract
Enzymes,
key
catalysts
in
biochemical
reactions,
are
prone
to
denaturation
under
harsh
conditions,
leading
reduced
stability
and
higher
costs.
Enzyme
immobilization,
using
carriers
like
magnetic
nanoparticles,
metal-organic
frameworks,
viruses,
is
a
common
solution.
T4
bacteriophage,
virulent
E.
coli
phage
containing
155
Hoc
870
Soc
proteins,
offers
cost-effective
highly
stable
platform
for
enzyme
immobilization.
In
this
study,
Soc-β-galactosidase
(Soc-β-gal)
was
immobilized
on
the
surface
of
bacteriophage
via
affinity
fixation
further
encapsulated
with
metal-polyphenol
network
(MPN)
coating.
Comparative
analysis
properties
revealed
that
enzyme,
β-gal
T4,
retained
over
85%
activity
after
6
hours
at
50°C,
while
free
Soc-β-gal
only
40.63%.
Moreover,
T4@TA-Ti
demonstrated
superior
stability,
retaining
92.88%
its
UV
exposure,
compared
10.21%
7.23%
Soc-β-gal.
The
MPN
coating
also
enhanced
resistance
proteolytic
degradation,
9.48%
exposure
proteinase
K,
contrast
4.62%
T4.
Overall,
these
results
demonstrate
immobilization
significantly
enhances
improves
extreme
pH,
ultraviolet
radiation,
other
environmental
stressors,
highlighting
potential
approach
biocatalytic
applications.
Language: Английский
Enhancing Laccase Production by Trametes hirsuta GMA-01 Using Response Surface Methodology and Orange Waste: A Novel Breakthrough in Sugarcane Bagasse Saccharification and Synthetic Dye Decolorization
Reactions,
Journal Year:
2024,
Volume and Issue:
5(3), P. 635 - 650
Published: Sept. 19, 2024
Trametes
hirsuta
GMA-01
was
cultivated
in
a
culture
medium
supplemented
with
orange
waste,
starch,
wheat
bran,
yeast
extract,
and
salts.
The
fungus
produced
several
holoenzymes,
but
the
laccase
levels
were
surprisingly
high.
Given
highlighted
applicability
of
laccases
various
biotechnological
areas
minimal
environmental
impact,
we
provided
strategy
to
increase
its
production
using
response
surface
methodology.
immobilization
into
ionic
supports
(CM-cellulose,
DEAE-agarose,
DEAE-cellulose,
DEAE-Sephacel,
MANAE-agarose,
MANAE-cellulose,
PEI-agarose)
found
be
efficient
recuperative,
showcasing
technical
prowess
research.
crude
extract
(CE)
CM-cellulose-immobilized
(ICE)
showed
optimum
activity
acidic
conditions
(pH
3.0)
at
70
°C
for
CE
60
ICE.
ICE
significantly
increased
thermostability
which
retained
21.6%
residual
after
240
min.
successfully
applied
sugarcane
bagasse
hydrolysis,
showing
13.83
±
0.02
µmol
mL−1
reducing
sugars
48
h.
Furthermore,
tested
dye
decolorization,
achieving
96.6%,
71.9%,
70.8%
decolorization
bromocresol
green,
bromophenol
blue,
orcein,
respectively
(0.05%
(w/v)
concentration).
properties
versatility
T.
different
purposes
are
interesting
notable,
opening
potential
applications
providing
valuable
insights
future
development.
Language: Английский