Creutzfeldt-Jakob Disease in a Saudi Female: A Case Report DOI Open Access
Fahad Albadr,

Saba M Aldusaymani,

Yousef Ahmed Aldobikhi

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Creutzfeldt-Jakob disease (CJD) is a rare, rapidly progressive, and incurable neurodegenerative disorder caused by prions. It invariably fatal classified under transmissible spongiform encephalopathies. This case report presents 66-year-old Saudi female who was admitted to the neurology department due advancing cognitive decline. The patient underwent diagnostic evaluation, including magnetic resonance imaging (MRI) electroencephalogram (EEG). Following month of hospitalization with psychosocial support, stable subsequently discharged. In conclusion, while CJD an uncommon condition, it should be considered in differential diagnosis patients presenting progressive dementia. Early accurate essential differentiate this untreatable from other treatable forms dementia facilitate potential future therapeutic interventions.

Language: Английский

A serial case report of hospitalized patients with Creutzfeldt-Jakob disease due to coronavirus disease (COVID)-19 in Brazil: A four-year profile DOI

Allan José Marques Lourenço Silva,

Patrícia Costa, Luiz Guilherme Marchesi Mello

et al.

Journal of the Neurological Sciences, Journal Year: 2025, Volume and Issue: 469, P. 123380 - 123380

Published: Jan. 4, 2025

Language: Английский

Citations

1
From long COVID to neurodegeneration DOI Creative Commons
Luis Del Carpio-Orantes

Brain Circulation, Journal Year: 2025, Volume and Issue: 11(1), P. 94 - 95

Published: Jan. 1, 2025

Language: Английский

Citations

0
A review of the sequelae of post Covid-19 with neurological implications (post-viral syndrome) DOI
Walter Struhal,

Doaa Almamoori

Journal of the Neurological Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123532 - 123532

Published: May 1, 2025

Language: Английский

Citations

0
Creutzfeldt-Jakob disease in a man surviving COVID-19: disentangling a casual or causal association by neuropathology DOI
Alessia Perna, Elisa Colaizzo, Anna Ladogana

et al.

Neurological Sciences, Journal Year: 2024, Volume and Issue: 45(6), P. 2419 - 2422

Published: April 5, 2024

Language: Английский

Citations

2
Creutzfeldt-Jakob disease: A comprehensive review of current understanding and research DOI
Harrinni Md Noor,

Muhammad Hadi Baqai,

Hufsa Naveed

et al.

Journal of the Neurological Sciences, Journal Year: 2024, Volume and Issue: 467, P. 123293 - 123293

Published: Nov. 12, 2024

Language: Английский

Citations

2
Creutzfeldt–Jakob Disease Associated with E200K Mutation and SARS-CoV2 Infection: Pure Coincidence or Neurodegenerative Acceleration? DOI Creative Commons
Elisa Colaizzo, Luca Prosperini, Antonio Petrucci

et al.

Clinical and Translational Neuroscience, Journal Year: 2024, Volume and Issue: 8(2), P. 16 - 16

Published: March 26, 2024

Several recent studies reported on some patients developing Creutzfeldt–Jakob disease (CJD) following coronavirus 2019, but, to the best of our knowledge, this case is first in Italy an onset a CJD genetic form (gCJD) immediately after COVID-19 infection. We present 51-year-old woman with positive family history for CJD, who, two months mild SARS-CoV-2 infection, presented rapidly progressing dementia diagnosed as through clinical features, imaging, electroencephalography, and cerebrospinal fluid analysis. Genetic testing revealed E200K mutation (p.Glu200Lys) c.598G>A, homozygosity methionine (MET) at codon 129, thus confirming diagnosis disease. She passed away later. Interestingly, confirms that homozygous gCJD are characterized by relatively younger age onset; moreover, it also sheds light neurodegeneration underlying both prion diseases In opinion, rising global prevalence neurodegenerative complications adds urgency study potential relationship, mostly elderly who may experience worse long-lasting outcomes systemically within nervous system.

Language: Английский

Citations

1
The “Tipping Point” : When Electroencephalography (EEG), Quantitative EEG (QEEG) and Standardized Low Resolution Brain Electromagnetic Tomography (sLORETA) in COVID Went From “Ceasure” To “Non- Priority” To “First-Line” Tool in Triage, Diagnosis, Monitoring and Therapy DOI Open Access
Priya Miranda,

Slav Danev,

Michael P. Alexander

et al.

Neurology and Neuroscience, Journal Year: 2024, Volume and Issue: 5(1)

Published: March 30, 2024

On the threshold of COVID outbreak; electroencephalography (EEG) was used in diagnosis, crossborder disease differential disease-staging, monitoring treatment, sedation and coma, neuro-therapy declaration brain death. EEG, quantitative EEG (QEEG), standardized low resolution electromagnetic tomography (sLORETA) use entered doldrums; reaching near “ceasure” due to restrictions. Between 2020-2023, tipped, going from “Ceasure” “First-Line” tool triage, therapy neurological, neurocognitive, neuropsychiatric, neuromuscular sequelae para- or acute- post-COVID-19. The present paper will discuss this “Tipping point” QEEG sLORETA use.

Language: Английский

Citations

0
Characterization of Laboratory-Confirmed Creutzfeldt-Jakob Disease From 3 Ontario Tertiary Care Centers Between 2012 and 2022: A Retrospective Cohort Study DOI Creative Commons

Kayla Gaete,

Soma Dalai,

Ana Cabrera

et al.

Open Forum Infectious Diseases, Journal Year: 2024, Volume and Issue: 11(10)

Published: Sept. 18, 2024

Abstract Background Globally, Creutzfeldt-Jakob disease (CJD) affects one in million people annually, but there is a paucity of recent Canadian data. This study summarizes epidemiology trends and diagnostic timelines laboratory-confirmed CJD cases three tertiary Ontario hospitals. Method Using laboratory information systems, we identified 30 patients with diagnosis between 2012 2022 at major hospitals Ontario. Retrospective chart reviews were then completed. Results Patients had mean 2.2 hospital visits (SD, 1.2) prior to being admitted for testing. The most common symptom presentations included loss coordination (63.3%), behavioral changes (60%), progressive mobility (53.4%), memory (50.0%), involuntary movements (50.0%). Magnetic resonance imaging findings showed potential 76.7% cases, 56.7% exhibited periodic sharp wave complexes characteristic on electroencephalogram. duration from onset microbiologic testing was 91 days 90.7). End-point quaking-induced conversion (EP-QuIC) cerebrospinal fluid positive 90.0% patients, while 83.3% tested 14-3-3 enzyme-linked immunosorbent assay. Elevated levels significantly correlated shorter death (R2 = 0.71, F 19.55, P .0022). Post-diagnosis, 46.7% discharged home, 16.6% transferred external palliative care or hospice facilities, 36.7% died during admission. time 121 120.7), 35 83.9). Conclusions highlights the importance early consideration when appropriate neurologic symptoms are present.

Language: Английский

Citations

0
Creutzfeldt-Jakob Disease in a Saudi Female: A Case Report DOI Open Access
Fahad Albadr,

Saba M Aldusaymani,

Yousef Ahmed Aldobikhi

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Creutzfeldt-Jakob disease (CJD) is a rare, rapidly progressive, and incurable neurodegenerative disorder caused by prions. It invariably fatal classified under transmissible spongiform encephalopathies. This case report presents 66-year-old Saudi female who was admitted to the neurology department due advancing cognitive decline. The patient underwent diagnostic evaluation, including magnetic resonance imaging (MRI) electroencephalogram (EEG). Following month of hospitalization with psychosocial support, stable subsequently discharged. In conclusion, while CJD an uncommon condition, it should be considered in differential diagnosis patients presenting progressive dementia. Early accurate essential differentiate this untreatable from other treatable forms dementia facilitate potential future therapeutic interventions.

Language: Английский

Citations

0