Transcriptome Sequencing-Based Screening of Key Melatonin-Related Genes in Ischemic Stroke DOI Open Access
Tianzhi Li, Hongyan Li, Sijie Zhang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11620 - 11620

Published: Oct. 29, 2024

Ischemic stroke (IS) is a complex syndrome of neurological deficits due to stenosis or occlusion the carotid and vertebral arteries for which there still no effective treatment. Melatonin, hormone secreted by pineal gland, has multiple biological effects, such as antioxidant anti-inflammatory properties, circadian rhythm regulation, tissue regeneration, demonstrating potential applications in treatment IS. The aim this study was investigate key melatonin-regulated genes associated with IS using transcriptome sequencing bioinformatics analyses explore their mechanisms action disease process. We obtained gene expression data related ischemic from Gene Expression Omnibus (GEO) database identified candidate machine learning algorithms. then assessed predictive power these PPI network analysis diagnostic models. Finally, series enrichment four genes: ADM, PTGS2, MMP9, VCAN. In addition, we determined mRNA levels an rat model qPCR found that all were significantly upregulated compared control group, consistent results previous analyses. Meanwhile, have functions regulating vascular tone, participating inflammatory response, influencing remodeling, cell adhesion proliferation, playing roles pathogenesis Therefore, suggest may serve prospective biomarkers help predict risk developing conclusion, elucidates first time role melatonin lays foundation in-depth studies on pathophysiology clinical diagnosis

Language: Английский

Dysfunctional mitochondria in age-related neurodegeneration: Utility of melatonin as an antioxidant treatment DOI Creative Commons
Russel J. Reıter, Ramaswamy Sharma, Walter Manucha

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 101, P. 102480 - 102480

Published: Sept. 3, 2024

Mitochondria functionally degrade as neurons age. Degenerative changes cause inefficient oxidative phosphorylation (OXPHOS) and elevated electron leakage from the transport chain (ETC) promoting increased intramitochondrial generation of damaging reactive oxygen nitrogen species (ROS RNS). The associated progressive accumulation molecular damage causes an increasingly rapid decline in mitochondrial physiology contributing to aging. Melatonin, a multifunctional free radical scavenger indirect antioxidant, is synthesized matrix neurons. Melatonin reduces ETC elevates ATP production; it also detoxifies ROS/RNS via SIRT3/FOXO pathway upregulates activities superoxide dismutase 2 glutathione peroxidase. influences glucose processing by In neurogenerative diseases, often adopt Warburg-type metabolism which excludes pyruvate mitochondria causing reduced acetyl coenzyme A production. Acetyl supports citric acid cycle OXPHOS. Additionally, required co-substrate for arylalkylamine-N-acetyl transferase, rate limits melatonin synthesis; therefore, production diminished cells that experience making more vulnerable stress. Moreover, endogenously produced diminishes during aging, further increasing components. More normal preserved aging with supplementation.

Language: Английский

Citations

12
Melatonin mitigates UV-induced tumorigenesis and suppresses hearing function deterioration in Xpa-deficient mice DOI
Mariko Tsujimoto,

T Fujita,

Tatsuya Furukawa

et al.

Journal of Dermatological Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Neuron-Glial2 (NG2) Cells: A Promising Target for Neuroinflammation-Related Neurodegeneration DOI Creative Commons
Zaw Myo Hein, Che Mohd Nasril Che Mohd Nassir, Muhammad Danial Che Ramli

et al.

Translational Research in Anatomy, Journal Year: 2025, Volume and Issue: unknown, P. 100395 - 100395

Published: March 1, 2025

Language: Английский

Citations

0
The Physiological Impact of Melatonin, Its Effect on the Course of Diseases and Their Therapy and the Effect of Magnetic Fields on Melatonin Secretion—Potential Common Pathways of Influence DOI Creative Commons
Marta Woldańska-Okońska, Kamil Koszela

Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 929 - 929

Published: July 31, 2024

Melatonin is a relic, due to its millions-of-years-old presence in chemical reactions, found evolutionarily diverse organisms. It has multidirectional biological function. controls diurnal rhythms, redox homeostasis, intestinal motor functions, mitochondrial biogenesis and fetal development antioxidant effects. also analgesic therapeutic The purpose of this paper describe the role melatonin vital processes occurring interaction with environment, particular reference various magnetic fields ubiquitous life animate matter, especially radio frequency/extra low frequency (RF/ELF EMF) static fields. most important part article potential effects on secretion resulting possible health some cases positively amplifies electromagnetic signal, intensifying effects, such as neurogenesis, or lowering blood pressure. In other cases, it stimulus that inhibits destruction aggravation lesions. Sometimes, however, contrast beneficial therapy, they intensify pathogenic multiple sclerosis by inflammatory process.

Language: Английский

Citations

2
Relationship Between Melatonin Receptor Agonists and Parkinson's Disease DOI Creative Commons
Yoshihiro Noguchi,

Rikuto Masuda,

Haruka Aizawa

et al.

Journal of Pineal Research, Journal Year: 2024, Volume and Issue: 76(5)

Published: Aug. 1, 2024

Abstract Parkinson's disease affects millions of people worldwide, and without significant progress in prevention treatment, its incidence prevalence could increase by more than 30% 2030. Researchers have focused on targeting sleep the circadian system as a novel treatment strategy for disease. This study investigated association between melatonin receptor agonists disease, using Food Drug Administration (FDA) Adverse Events Reporting System (FAERS). The target drugs were including ramelteon, tasimelteon, agomelatine. cases defined according to Medical Dictionary Regulatory Activities (MedDRA) 25.0; Standardized MedDRA Query (SMQ) both “narrow” “broad” preferred terms (PTs) associated with (ramelteon, agomelatine) was evaluated reporting odds ratio. Upon analyzing data from all patients registered FAERS, ramelteon (ROR: 0.66, 95% confidence interval [95% CI]: 0.51–0.84) tasimelteon 0.49, CI: 0.38–0.62) showed negative correlations Conversely, only agomelatine positively correlated 2.63, 2.04–3.40). These results suggest that among agonists, are negatively In contrast, shown be should used research develop fully considering limitations spontaneous system.

Language: Английский

Citations

1
Hypoxia-inducible factor-1 as targets for neuroprotection : from ferroptosis to Parkinson’s disease DOI

Changyong Wang,

Shanyu Lv,

Zhao Hong-yan

et al.

Neurological Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 28, 2024

Language: Английский

Citations

1
Protective Activity of Melatonin Combinations and Melatonin‐Based Hybrid Molecules in Neurodegenerative Diseases DOI Creative Commons
Francesca Galvani,

Mariarosaria Cammarota,

Federica Vacondio

et al.

Journal of Pineal Research, Journal Year: 2024, Volume and Issue: 76(8)

Published: Nov. 25, 2024

ABSTRACT The identification of protective agents for the treatment neurodegenerative diseases is mainstay therapeutic goal to modify disease course and arrest irreversible disability progression. Pharmacological therapies synergistically targeting multiple pathogenic pathways, including oxidative stress, mitochondrial dysfunction, inflammation, are prime candidates neuroprotection. Combination or synergistic therapy with melatonin, whose decline correlates altered sleep/wake cycle impaired glymphatic “waste clearance” system in diseases, has a great potential treat inflammatory states. Despite outcomes observed preclinical studies, mild poor were clinical settings, suggesting that melatonin combinations promoting actions at appropriate doses might be more suitable multifactorial disorders. In this review, we first summarize key pathways contributing cell protection its implication Alzheimer's (AD), Parkinson's (PD), sclerosis (MS). We remark major controversies field, mostly generated by lack common consensus optimal dosing, molecular targets, toxicity. Then, review literature investigating efficacy approved investigational neuroprotective melatonin‐containing hybrid molecules, both vitro animal models AD, PD, MS, as well add‐on settings. highlight rationale such focus on comparison single‐agent assays which an additive effect been achieved. conclude better characterization mechanisms underlying under neuroinflammation needs tackled advance successful translation combination melatonin‐based molecules.

Language: Английский

Citations

1
Potentiality of Marine Microbial Metabolites in the Remedy of Alzheimer’s Disease: A Comprehensive Review DOI

Srijita Paul,

Mouli Dey,

Bishnupriya Roy

et al.

Proceedings of the Zoological Society, Journal Year: 2024, Volume and Issue: 77(3), P. 293 - 303

Published: Aug. 23, 2024

Language: Английский

Citations

0
Transcriptome Sequencing-Based Screening of Key Melatonin-Related Genes in Ischemic Stroke DOI Open Access
Tianzhi Li, Hongyan Li, Sijie Zhang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11620 - 11620

Published: Oct. 29, 2024

Ischemic stroke (IS) is a complex syndrome of neurological deficits due to stenosis or occlusion the carotid and vertebral arteries for which there still no effective treatment. Melatonin, hormone secreted by pineal gland, has multiple biological effects, such as antioxidant anti-inflammatory properties, circadian rhythm regulation, tissue regeneration, demonstrating potential applications in treatment IS. The aim this study was investigate key melatonin-regulated genes associated with IS using transcriptome sequencing bioinformatics analyses explore their mechanisms action disease process. We obtained gene expression data related ischemic from Gene Expression Omnibus (GEO) database identified candidate machine learning algorithms. then assessed predictive power these PPI network analysis diagnostic models. Finally, series enrichment four genes: ADM, PTGS2, MMP9, VCAN. In addition, we determined mRNA levels an rat model qPCR found that all were significantly upregulated compared control group, consistent results previous analyses. Meanwhile, have functions regulating vascular tone, participating inflammatory response, influencing remodeling, cell adhesion proliferation, playing roles pathogenesis Therefore, suggest may serve prospective biomarkers help predict risk developing conclusion, elucidates first time role melatonin lays foundation in-depth studies on pathophysiology clinical diagnosis

Language: Английский

Citations

0