Healthy ageing and longevity, Journal Year: 2024, Volume and Issue: unknown, P. 255 - 275
Published: Jan. 1, 2024
Language: Английский
Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1716 - 1716
Published: Aug. 1, 2024
The term 'inflammaging' has been coined to describe the chronic state of inflammation derived from ongoing cycles tissue damage and subsequent immune responses. This inflammatory status contributes decline organs physiological functions, accelerates aging process, increases risk age-related illnesses death. During aging, gut microbiota (GM) undergoes significant changes, including a decreased diversity species, in beneficial bacteria, rise proinflammatory ones, resulting persistent low-grade inflammation. Moreover, environmental factors, such as diet medications, contribute changes GM function, preventing or promoting inflammaging. narrative review aims clarify underlying mechanisms inflammaging specifically investigate influence several factors on these mechanisms, while also exploring potential differences related sex. lifestyle pharmacological interventions will be suggested promote healthy aging.
Language: Английский
Citations
2
Immunity & Ageing, Journal Year: 2024, Volume and Issue: 21(1)
Published: Nov. 30, 2024
Abstract Antibodies are essential to immune homeostasis due their roles in neutralizing pathogenic agents. However, failures central and peripheral checkpoints that eliminate autoreactive B cells can undermine self-tolerance generate autoantibodies mistakenly target self-antigens, leading inflammation autoimmune diseases. While well-studied some communicable diseases, chronic conditions, such as obesity aging, less understood. Obesity aging share similar aspects of dysfunction, diminished humoral responses heightened inflammation, which disrupt tolerance foster autoantigen production, thus giving rise autoantibodies. In return, these events may also contribute the pathophysiology associated disorders linked development immunosenescence, an age-related decline function heightens vulnerability infections, loss self-tolerance. Furthermore, cumulative exposure antigens cellular debris during perpetuates pro-inflammatory pathways, linking immunosenescence with other hallmarks, proteostasis mitochondrial dysfunction. This review examines mechanisms driving autoantibody generation discusses key putative antigenic targets across conditions. We explore therapeutic potential emerging approaches, CAR-T/CAAR-T therapies, vaccines, BiTEs, tackle autoimmune-related conditions obesity.
Language: Английский
Citations
2
International journal of Nutrition Pharmacology Neurological Diseases, Journal Year: 2024, Volume and Issue: 14(2), P. 164 - 176
Published: April 1, 2024
This scoping review examines the multifaceted phenomenon of frailty in context an aging global population. The exploration encompasses definition and features frailty, its diverse causes, impact on quality life for affected individuals. Focusing lifestyle factors, including physical activity, nutrition, sleep, stress management, highlights potential these modifiable elements preventing managing frailty. Key findings underscore connected nature physical, psychological, social dimensions frailty’s development. For clinicians, personalized interventions involving exercise regimens, nutritional counseling, management are recommended. Empowering people with understanding that is not inevitable consequence aging, calls a collective commitment to awareness, prevention, further study. By fostering comprehensive collaborative approach, we aim enhance well-being individuals contribute healthier more resilient future.
Language: Английский
Citations
1
European Journal of Trauma and Emergency Surgery, Journal Year: 2024, Volume and Issue: 50(5), P. 2155 - 2164
Published: Aug. 10, 2024
Abstract Background Appendicitis is the most frequent global abdominal surgical emergency. An ageing population, who often exhibit atypical symptoms and delayed presentations, challenge conventional diagnostic treatment paradigms. Objectives This study aims to delineate disparities in presentation, management, outcomes between elderly patients younger adults suffering from acute appendicitis. Methods subgroup analysis forms part of ESTES SnapAppy, a time-bound multi-center prospective, observational cohort study. It includes aged 15 years above underwent laparoscopic appendectomy during defined 90-day period across multiple centers. Statistical comparisons were performed using appropriate tests with significance set at p < 0.05. Results The comprised 521 (≥65 years) 4,092 (18–64 years). Elderly presented later (mean duration symptoms: 7.88 vs. 3.56 days; 0.001) frequently required computed tomography (CT) scans for diagnosis (86.1% 54.0%; 0.001). incidence complicated appendicitis was higher (46.7% 20.7%; Delays intervention notable (85.0% operated within 24 h 88.7%; = 0.018), longer operative times (71.1 60.3 min; Postoperative complications significantly (27.9% 12.9%; 0.001), including severe (6.9% 2.4%; prolonged hospital stays (7.9 3.6 Conclusions Our findings highlight significant differences clinical course compared patients, suggesting need age-adapted pathways strategies improve this vulnerable population.
Language: Английский
Citations
1
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: July 13, 2024
Abstract The Apple polysaccharides (AP), extracted from the fruit of apple, has been used to treat multiple pathological diseases. In this study, we evaluated effects AP on cognitive impairment and intestinal aging in naturally mice. As a result, it was found that could improve spatial learning memory mice through Morris water maze experiment. Additionally, intervention can upregulate expression nerve growth factor (BDNF), postsynaptic marker (PSD95), presynaptic (SYP) proteins. Moreover, enhance total antioxidant capacity, reduce level pro-inflammatory cytokine, inhibit activation NF-κB signaling pathway, exerting anti-inflammatory functions. And administration restored mucosal barrier function, reduced apoptosis related also altered gut microbiota At genus level, decreased abundance Helicobacter Bilophila , while increased Lactobacillus Bacteroides . summary, these data demonstrate treatment alleviate impairment, oxidative stress, inflammatory reactions, repair barrier, aging, alter specific microbial characteristics, ultimately improving health elderly.
Language: Английский
Citations
0
Healthy ageing and longevity, Journal Year: 2024, Volume and Issue: unknown, P. 255 - 275
Published: Jan. 1, 2024
Language: Английский
Citations
0