DiabSense: early diagnosis of non-insulin-dependent diabetes mellitus using smartphone-based human activity recognition and diabetic retinopathy analysis with Graph Neural Network DOI Creative Commons

Md Nuho Ul Alam,

Ibrahim Hasnine,

Erfanul Hoque Bahadur

et al.

Journal Of Big Data, Journal Year: 2024, Volume and Issue: 11(1)

Published: Aug. 3, 2024

Non-Insulin-Dependent Diabetes Mellitus (NIDDM) is a chronic health condition caused by high blood sugar levels, and if not treated early, it can lead to serious complications i.e. blindness. Human Activity Recognition (HAR) offers potential for early NIDDM diagnosis, emerging as key application HAR technology. This research introduces DiabSense, state-of-the-art smartphone-dependent system staging of NIDDM. DiabSense incorporates Diabetic Retinopathy (DR) upon leveraging the power two different Graph Neural Networks (GNN). uses comprehensive array 23 human activities resembling symptoms, DR prevalent complication Attention Network (GAT) in achieved 98.32% accuracy on sensor data, while Convolutional (GCN) Aptos 2019 dataset scored 84.48%, surpassing other models. The trained GCN analyzed retinal images four experimental subjects report generation, GAT generated their average duration daily over 30 days. non-diabetic periods diabetic patients were measured compared with subjects, which helped generate risk factors. Fusing factors conditions enabled diagnosis recommendations despite absence any apparent symptoms. comparison outcome clinical reports was conducted using A1C test. test results confirmed accurate assessment requirements system. Overall, exhibits significant ensuring treatment, improving millions lives worldwide.

Language: Английский

Associations between Skin Autofluorescence Levels with Cardiovascular Risk and Diabetes Complications in Patients with Type 2 Diabetes DOI Creative Commons
Delia Reurean‐Pintilei, Anca Pantea Stoian, Teodor Salmen

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(4), P. 890 - 890

Published: April 17, 2024

Advanced Glycation End Products (AGEs) contribute to the pathophysiology of type 2 diabetes mellitus (T2DM) and cardiovascular (CV) diseases (CVDs), making their non-invasive assessment through skin autofluorescence (SAF) increasingly important. This study aims investigate relationship between SAF levels, risk, diabetic complications in T2DM patients. We conducted a single-center, cross-sectional at Consultmed Hospital Iasi, Romania, including 885 The levels was performed with AGE Reader™, (Diagnoptics, Groningen, Netherlands). CVD prevalence 13.9%, according CV risk category distribution, 6.1% fell into moderate-risk, 1.13% high-risk, 92.77% very-high-risk category. duration DM averaged 9.0 ± 4.4 years mean HbA1c 7.1% 1.3. After adjusting for age eGFR, values showed correlation multivariate regression model, where 1 SD increase associated 0.105 (Nagelkerke R

Language: Английский

Citations

6
Investigation of the Potential Association Between Atherosclerotic Cardiovascular Disease Risk Score and Diabetic Retinopathy in Patients with Type 2 Diabetes: A Cross-Sectional Study DOI Creative Commons
Chrysa Agapitou, Theodoros Ν. Sergentanis, Effie Papageorgiou

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 633 - 633

Published: March 5, 2025

Purpose: To examine the association between diabetic retinopathy (DR) and atherosclerotic cardiovascular disease (ASCVD) risk score using “ASCVD Risk Estimator Plus” tool in patients with type 2 diabetes mellitus (DM) to assess factors potentially associated DR. Methods: Participants study included 181 DM who underwent a thorough ophthalmic examination, including best-corrected visual acuity (BCVA) measurement, dilated fundoscopy, fundus photography, an optical coherence tomography (OCT), OCT-angiography (OCT-A). DR was graded as no apparent (NDR), mild non-proliferative (NPDR), moderate NPDR, severe or proliferative (PDR). In addition, detailed medical history of recorded, while by American College Cardiology used calculate ASCVD risk. Results: The score, derived Plus”, not found be significantly correlated (p = 0.191). Multivariable logistic regression analysis showed that independently duration (multivariable OR 3.16, 95% CI: 1.55–6.44, p 0.002), HbA1c levels 2.94, 1.37–6.32, 0.006), presence neuropathy 3.59, 1.43–9.05, 0.007). multivariable multinomial analysis, NPDR development RR 3.31, 1.57–6.97, 2.24, 1.00–5.02, 0.050), RR: 3.94, 1.54–10.11, 0.004), PDR only 6.88, 2.19–21.63, 0.001). Conclusions: it calculated tool, Factors were duration, levels, neuropathy.

Language: Английский

Citations

0
Double Diabetes: A Converging Metabolic and Autoimmune Disorder Redefining the Classification and Management of Diabetes DOI Open Access

Raj K Chaudhary,

O. Ali,

Amrendra Kumar

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

This review explores the pathophysiology, clinical implications, and management of double diabetes. The increasing prevalence obesity, sedentary lifestyles, genetic predisposition has blurred difference between type 1 2 diabetes, leading to diagnostic therapeutic challenges. Double diabetes presents with overlapping symptoms from both types, making accurate diagnosis crucial. Biomarkers, such as C-peptide levels, autoantibody testing, insulin resistance markers, help differentiate classic subtypes. Early intervention is necessary because condition's elevated risk microvascular macrovascular consequences, retinopathy, nephropathy, cardiovascular disease. Effective integrates pharmacological lifestyle approaches. Metformin, sodium-glucose cotransporter (SGLT2) inhibitors, glucagon-like peptide-1 (GLP-1) receptor agonists, therapy adjustments all boost glycemic control metabolic results. Additionally, structured exercise, dietary modifications, weight are essential for reducing preserving beta-cell activity. potential precision medicine, artificial intelligence (AI)-driven healthcare, continuous glucose monitoring (CGM) offers promising advancements personalized treatment strategies. Future research should focus on targeted immunotherapies, profiling, refined guidelines improve early detection individualized treatment, long-term outcomes. emphasizes need a multidisciplinary approach in managing ensuring diagnosis, optimized improved health mitigate complications.

Language: Английский

Citations

0
Optimal amount of vigorous-intensity physical activity for lowering incidence of microvascular diseases: A prospective cohort study from the UK Biobank DOI
Lan Yu, Guangbin Sun,

Yinyue Liu

et al.

Diabetes Research and Clinical Practice, Journal Year: 2025, Volume and Issue: unknown, P. 112203 - 112203

Published: April 1, 2025

Language: Английский

Citations

0
A Pilates Exercise Program as a Therapeutic Strategy in Older Adults with Type 2 Diabetes: Effects on Functional Capacity and Blood Glucose DOI Open Access

Beatriz Ruiz-Ariza,

Fidel Hita‐Contreras, Agustín Aibar‐Almazán

et al.

Healthcare, Journal Year: 2025, Volume and Issue: 13(9), P. 1012 - 1012

Published: April 28, 2025

Background/Objectives: Older adults with type 2 diabetes mellitus (T2DM) often experience impaired physical function and metabolic control. This study aimed to evaluate the effectiveness of a 12-week Pilates-based intervention on blood glucose concentration in this population. Methods: A randomized controlled trial was conducted 104 older (mean age: 70.6 ± 3.15 years; 70.2% women), all diagnosed T2DM. The participants were assigned control group (CG, n = 52) or Pilates training (PG, 52). included 24 sessions over 12 weeks (2 sessions/week, 60 min each). Outcomes assessed pre- post-intervention capillary glucose, handgrip strength, functional mobility (Timed Up Go), balance (Berg Balance Scale), flexibility (Chair Sit-and-Reach Test Back Scratch Test). Results: Compared group, showed statistically significant improvements levels (-4.06 mg/dL (p < 0.001; d 0.68)), strength (+1.76 kg 0.48)), gait speed 0.53), score) (+2.37 points 0.66)), (improvements upper limbs (BST, 0.78-0.98) lower (CSRT, 1.07 right; 0.63 left)). Conclusions: program led glycemic control, muscular speed, balance, These findings support as safe, effective, adaptable non-pharmacological promote health

Language: Английский

Citations

0
Mitigating diabetes associated with reactive oxygen species (ROS) and protein aggregation through pharmacological interventions DOI Creative Commons
Giulia Bennici, Hanan Almahasheer,

Mawadda Alghrably

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(25), P. 17448 - 17460

Published: Jan. 1, 2024

Diabetes mellitus, a complex metabolic disorder, presents growing global health challenge.

Language: Английский

Citations

2
Quinoline-thiosemicarbazone-1,2,3-triazole-acetamide derivatives as new potent α-glucosidase inhibitors DOI Creative Commons

Aynaz Khademian,

Mohammad Halimi,

Reza Azarbad

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 28, 2024

In this work, a novel series of quinoline-thiosemicarbazone-1,2,3-triazole-aceamide derivatives 10a-n as new potent α-glucosidase inhibitors was designed, synthesized, and evaluated. All the synthesized were more than acarbose (positive control). Representatively, (E)-2-(4-(((3-((2-Carbamothioylhydrazineylidene)methyl)quinolin-2-yl)thio)methyl)-1H-1,2,3-triazol-1-yl)-N-phenethylacetamide (10n), most entry, with IC50 = 48.4 µM 15.5-times acarbose. According to kinetic study, compound 10n competitive inhibitor against α-glucosidase. This formed desired interactions important residues binding pocket favorable energy in molecular docking dynamics. Compounds 10n, 10e, 10 g compounds among evaluated term pharmacokinetics toxicity via online servers. These evaluations predicted that had good pharmacokinetic properties profile.

Language: Английский

Citations

2
Diabetic nephropathy: Current treatments and tissue engineering strategies DOI Open Access
Tawil Bill,

Kwak William

Journal of Applied Biotechnology & Bioengineering, Journal Year: 2024, Volume and Issue: 11(3), P. 64 - 71

Published: July 1, 2024

Kidney complications are extremely common in diabetic patients, affecting around 40% of those with type 1 and 2 diabetes, is the leading cause end-stage kidney disease. Due to increasingly processed foods sedentary habits, nephropathy (DN) continues grow prevalence all over world. In just 21st century alone, number cases for chronic disease nearly doubled. come many forms such as hyperglycemia, glomerulosclerosis, proteinuria, hypertension name a few. Despite severity DN, cure does not currently exist. At later stages nephropathy, dialysis renal transplantation remain only options even most advanced tissue engineering products have entered early clinical trials. This paper provides an overview underlying causes list current treatments, development.

Language: Английский

Citations

0
A Prospective Cross-Sectional Study on the Correlation of Adenosine Deaminase and HbA1c With Microvascular Complications in Type 2 Diabetes Mellitus at a Tertiary Care Hospital in Central India DOI Open Access

Sarang S Raut,

Anil Wanjari,

Vinit Deolikar

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 2, 2024

Background Type 2 diabetes mellitus (T2DM) is a prevalent chronic condition characterized by hyperglycemia, which can lead to various microvascular complications, including diabetic nephropathy, neuropathy, and retinopathy. Identifying reliable biomarkers for early detection risk stratification of these complications crucial improving patient outcomes. Adenosine deaminase (ADA) HbA1c have emerged as potential markers associated with immune function, inflammation, long-term glycemic control. This study investigates the correlation between ADA levels in patients T2DM. Material methods prospective observational cross-sectional involved 150 diagnosed T2DM, focusing on those Clinical data were collected through interviews, clinical examinations, laboratory tests, measurements fasting blood glucose, HbA1c, serum creatinine, levels, urine protein creatinine ratio (UPCR). Fundus examinations nerve conduction velocity (NCV) tests performed assess retinopathy respectively. Data analyzed using SPSS version 25.0 (IBM Corp., Armonk, New York), statistical evaluate complications. Results The found significant elevated Higher particularly nephropathy (p=0.003), while showed positive all three complications: findings suggest that serve valuable identifying at higher developing Conclusion highlights assessment T2DM patients. Routine monitoring could improve management prognosis enabling timely interventions prevent or mitigate progression Further research needed explore underlying mechanisms linking validate its utility.

Language: Английский

Citations

0
The Relationship Between Hand Abnormalities and Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus DOI Open Access
Feyzahan Ekici, Hüseyin Fındık, Muhammet Kaim

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(22), P. 6723 - 6723

Published: Nov. 8, 2024

The link between diabetes mellitus (DM) and pathological conditions of the hand has been previously investigated. Retinopathy is one most common microvascular complications DM. In this study, we aimed to evaluate relationship abnormalities retinopathy in patients with type 2

Language: Английский

Citations

0