COVID-19 Modified mRNA “Vaccines”: Lessons Learned from Clinical Trials, Mass Vaccination, and the Bio-Pharmaceutical Complex, Part 2

International Journal of Vaccine Theory Practice and Research, Journal Year: 2024, Volume and Issue: 3(2), P. 1275 - 1344

Published: Aug. 16, 2024

The COVID-19 modified mRNA (modmRNA) lipid nanoparticle-based “vaccines” are not classical antigen-based vaccines but instead prodrugs informed by gene therapy technology. Of considerable note, these products have been linked to atypical adverse and serious event profiles. As discussed in Part 1, health-related risks drawbacks were drastically misreported underreported the Pfizer Moderna trial evaluations of genetic products. Now 2, we examine main structural functional aspects injectables. modmRNA injectable introduce a unique set biological challenges human body with potential induce an extensive range adverse, crippling, life-threatening effects. Based on fact that there is no current method quantify host (cell-based) spike protein production vivo following injection prodrugs, standard “dose”. This part due differences output, which depends cell metabolism transfection efficiency. It therefore difficult predict profiles individual basis, considering millions adults across world reported severe events context products, valid concerns raised regarding infants younger age groups for whom poses only minimal risks. We address process-related impurities inherent mass posed contaminants. then categorize principal associated brief systems-based synopsis each six domains harms: (1) cardiovascular, (2) neurological, (3) hematologic; (4) immunological, (5) oncological, (6) reproductive. conclude discussion primary public health regulatory issues arising from this evidence-informed synthesis literature reiterate urgency imposing global moratorium modmRNA-LNP-based platform.

Language: Английский

---

Official risk communication for COVID-19 and beyond: can we do a better job?

Environment Systems & Decisions, Journal Year: 2024, Volume and Issue: 44(2), P. 293 - 300

Published: June 1, 2024

Abstract The COVID-19 pandemic strained the infrastructure of public health systems worldwide and unearthed social institutional challenges operating in a global crisis. This was exacerbated United States (U.S.), as risk communication messages from local, state federal officials were rife with conflicting information. In this article, we unpack perils flawed how it puts people at greater for infection other secondary risks stemming mitigation behaviors. choice to engage preventive behaviors, such distancing, wearing facemasks, frequently washing hands, differed dramatically across populations. On one extreme, some individuals, which call under-cautious, hesitant follow guidance regarding putting them COVID-19-associated morbidity. end spectrum is another group, over-cautious, who chose physically remove themselves interactions, going beyond appropriate recommendations experts mitigate risk. group may experience associated pandemic, mental issues, obesity, sedentary lifestyle. infrastructural encountered during must be further explored mitigated. future, these campaigns need target both under-cautious extreme groups can potentially suffer consequences pandemic.

Language: Английский

---

Heat Waves: A Bibliometric Analysis of Thermotherapy Research

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: July 29, 2024

This bibliometric study analyzes the evolving field of thermotherapy, a medical treatment that utilizes heat to treat various conditions, including cancer, by applying controlled temperatures targeted tissues. Utilizing bibliographic data from core collection Web Science and analysis software Biblioshiny VOSviewer, we analyzed several key metrics gain insights into development trends in thermotherapy research. The annual scientific production revealed significant increase publications over past two decades, reflecting growing interest this field. Analysis most relevant authors sources highlighted contributors influential journals. Trend topics demonstrated shift early focus areas like hyperthermia laser-induced recent advancements involving nanoparticles combination therapies. thematic map provided core, emerging, niche within research landscape. A historiograph traced chronological publications, while co-occurrence keywords coupling documents identified major themes interconnections literature. International collaborations were mapped, showing global nature gaps, need for large-scale clinical trials, interdisciplinary approaches, standardized protocols. Practical implications suggest focusing on delivery systems, expanding cancer research, fostering collaborative projects advance

Language: Английский

---

Cancer Mortality Surges Post COVID ModRNA Vaccination Ronald Palacios Castrillo

European Journal of Clinical and Biomedical Sciences, Journal Year: 2024, Volume and Issue: 10(2), P. 23 - 27

Published: June 29, 2024

Recent investigations have revealed a concerning association between the administration of third dose ModRNA COVID-19 vaccine and statistically significant increases in cancer mortality rates. A study conducted Japan highlighted this correlation, noting marked rise cancer-related deaths post-vaccination. This phenomenon is not isolated to Japan; similar trends been observed Europe, Australia, USA, with an excess reported from 2020 2023 compared 2019. In review, we explore seven potential mechanisms through which vaccines may contribute initiation progression cancer. Each mechanism discussed detail, focus on underlying molecular cellular pathways. The for varied combinations these influence different types also considered, providing comprehensive overview how might impact biology. Our analysis underscores necessity further research elucidate precise relationship vaccination progression. Understanding critical developing strategies mitigate adverse effects while harnessing benefits vaccination.

Language: Английский

---