The effect of bempedoic acid on histopathologic changes associated with natural aging in rat lungs DOI Creative Commons
Serap Argun Barış, Özgür Barış, Hüseyin Kaya

et al.

BMC Pulmonary Medicine, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 28, 2025

The process of aging is characterized by a series physiological, cellular, and immunological changes in tissues. Bempedoic acid an antioxidant, anti-inflammatory, cholesterol-lowering drug that does not belong to the statin class. objective this study was assess impact bempedoic on age-related histopathological alterations rat lungs. A total 40 Wistar-Albino male rats (275-357 g) were included study, with 10 each experimental group [Young control (YC), Young + (YD), Elderly (EC), (ED)]. (30 mg/kg/day) administered orally for one month. housed under controlled conditions minimize external stressors. Geropathological Grading System (GGP) used standardize evaluation findings Some lesions classified as either present or absent, whereas others evaluated scale 0-4 according their severity. Composite lesion scores calculated rat. Additionally, presence severity emphysema lungs recorded. Although median composite score higher elderly groups, difference statistically significant (p = 0.7). distribution cells associated passive congestion, heart failure, atelectasis 0.024 p 0.015, respectively). prevalence perivascular inflammation significantly compared other groups. Moreover, no cases moderate-to-severe observed 0.019). severe 0.044). It hypothesized statins, class antihyperlipidemic drugs, exert protective effect against due ability correct oxidative damage. Similarly, acid's fat oxidation cholesterol metabolism may be its role

Language: Английский

The effect of bempedoic acid on histopathologic changes associated with natural aging in rat lungs DOI Creative Commons
Serap Argun Barış, Özgür Barış, Hüseyin Kaya

et al.

BMC Pulmonary Medicine, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 28, 2025

The process of aging is characterized by a series physiological, cellular, and immunological changes in tissues. Bempedoic acid an antioxidant, anti-inflammatory, cholesterol-lowering drug that does not belong to the statin class. objective this study was assess impact bempedoic on age-related histopathological alterations rat lungs. A total 40 Wistar-Albino male rats (275-357 g) were included study, with 10 each experimental group [Young control (YC), Young + (YD), Elderly (EC), (ED)]. (30 mg/kg/day) administered orally for one month. housed under controlled conditions minimize external stressors. Geropathological Grading System (GGP) used standardize evaluation findings Some lesions classified as either present or absent, whereas others evaluated scale 0-4 according their severity. Composite lesion scores calculated rat. Additionally, presence severity emphysema lungs recorded. Although median composite score higher elderly groups, difference statistically significant (p = 0.7). distribution cells associated passive congestion, heart failure, atelectasis 0.024 p 0.015, respectively). prevalence perivascular inflammation significantly compared other groups. Moreover, no cases moderate-to-severe observed 0.019). severe 0.044). It hypothesized statins, class antihyperlipidemic drugs, exert protective effect against due ability correct oxidative damage. Similarly, acid's fat oxidation cholesterol metabolism may be its role

Language: Английский

Citations

0