Ketogenic diet, adenosine, and dopamine in addiction and psychiatry DOI Creative Commons
David N. Ruskin, Luis A. Martinez, Susan A. Masino

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 10, 2025

Adhering to the ketogenic diet can reduce or stop seizures, even when other treatments fail, via mechanism(s) distinct from available therapies. These results have led interest in for treating conditions such as Alzheimer’s disease, depression and schizophrenia. Evidence points neuromodulator adenosine a key mechanism underlying therapeutic benefits of diet. Adenosine represents unique direct link among cell energy, neuronal activity, gene expression, receptors form functional heteromers with dopamine receptors. The importance dopaminergic system is established addiction, are challenges modulating directly. A mediator that could antagonize dopamine’s effects would be useful, due its function location. Studies report improves cognition, sociability, perseverative behaviors, might improve depression. Many translational opportunities based on diet/adenosine come fore, including autism spectrum disorder, painful conditions, range hyperdopaminergic disorders.

Language: Английский

Ketogenic diet, adenosine, and dopamine in addiction and psychiatry DOI Creative Commons
David N. Ruskin, Luis A. Martinez, Susan A. Masino

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 10, 2025

Adhering to the ketogenic diet can reduce or stop seizures, even when other treatments fail, via mechanism(s) distinct from available therapies. These results have led interest in for treating conditions such as Alzheimer’s disease, depression and schizophrenia. Evidence points neuromodulator adenosine a key mechanism underlying therapeutic benefits of diet. Adenosine represents unique direct link among cell energy, neuronal activity, gene expression, receptors form functional heteromers with dopamine receptors. The importance dopaminergic system is established addiction, are challenges modulating directly. A mediator that could antagonize dopamine’s effects would be useful, due its function location. Studies report improves cognition, sociability, perseverative behaviors, might improve depression. Many translational opportunities based on diet/adenosine come fore, including autism spectrum disorder, painful conditions, range hyperdopaminergic disorders.

Language: Английский

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