Kinetic Study of In Vitro Release of Neem from Chitosan Biopolymer and Assessment of Its Biological Effectiveness DOI Open Access

Yasodani Nishshanka,

Charitha Thambiliyagodage, Madara Jayanetti

et al.

Polymers, Journal Year: 2025, Volume and Issue: 17(5), P. 702 - 702

Published: March 6, 2025

The study examined the sustained release of neem from polymeric carrier system chitosan by varying drug content, ionic strength medium, and pH. Six different kinetic models, i.e., Korsmeyer-Peppas (KP), Peppas-Sahlin (PS), Higuchi, Hixson-Crowell, Zero order, First order were used to investigate kinetics. Based on R2 values, KP PS models chosen mechanism biopolymer. values found for model parameters n m in differ noticeably, suggesting that Fickian diffusion Case II relaxation are important components chitosan. At lower strengths pH is released composite mostly diffusion. diphenyl-2-picrylhydrazyl assay served assess composite's antioxidant properties. properties ranged 3.56 ± 1.89% at 10 μg/mL 51.28 1.14% 70 μg/mL. ability inhibit denaturation egg albumin was also tested it 59.68 0.93% 25 187.63 3.53% 1600 has exhibited antibacterial activity against Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, proved be highly effective P. aeruginosa concentrations S. aureus higher concentrations. resulting inhibition zones 5 mg/mL 16.5 2.25 mm, 14.83 0.6 respectively, whereas 16.67 0.33 mm 20 mg/mL. neem-chitosan minimum inhibitory concentration/minimum bactericidal concentration ratio K. greater than 4, they trigger bacteriostatic outcomes, E. which means effects evident.

Language: Английский

Kinetic Study of In Vitro Release of Neem from Chitosan Biopolymer and Assessment of Its Biological Effectiveness DOI Open Access

Yasodani Nishshanka,

Charitha Thambiliyagodage, Madara Jayanetti

et al.

Polymers, Journal Year: 2025, Volume and Issue: 17(5), P. 702 - 702

Published: March 6, 2025

The study examined the sustained release of neem from polymeric carrier system chitosan by varying drug content, ionic strength medium, and pH. Six different kinetic models, i.e., Korsmeyer-Peppas (KP), Peppas-Sahlin (PS), Higuchi, Hixson-Crowell, Zero order, First order were used to investigate kinetics. Based on R2 values, KP PS models chosen mechanism biopolymer. values found for model parameters n m in differ noticeably, suggesting that Fickian diffusion Case II relaxation are important components chitosan. At lower strengths pH is released composite mostly diffusion. diphenyl-2-picrylhydrazyl assay served assess composite's antioxidant properties. properties ranged 3.56 ± 1.89% at 10 μg/mL 51.28 1.14% 70 μg/mL. ability inhibit denaturation egg albumin was also tested it 59.68 0.93% 25 187.63 3.53% 1600 has exhibited antibacterial activity against Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, proved be highly effective P. aeruginosa concentrations S. aureus higher concentrations. resulting inhibition zones 5 mg/mL 16.5 2.25 mm, 14.83 0.6 respectively, whereas 16.67 0.33 mm 20 mg/mL. neem-chitosan minimum inhibitory concentration/minimum bactericidal concentration ratio K. greater than 4, they trigger bacteriostatic outcomes, E. which means effects evident.

Language: Английский

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