Impact of Clindamycin on the Oral-Gut Axis: Gastrointestinal Side Effects and Clostridium difficile Infection in 45 Patients DOI Open Access

Elizabeth Litvinov,

Alexander V. Litvinov

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

Introduction The use of antibiotics such as oral clindamycin has been effective in treating bacterial infections. However, this medication often comes with significant side effects, particularly those affecting the gastrointestinal (GI) system. This study aims to evaluate impact different doses on GI health, specifically examining effects like stomach upset, diarrhea duration, pain, and recovery time. Given that is frequently prescribed, understanding its oral-gut axis critical optimizing antibiotic therapy reducing adverse events. Background Clindamycin, a lincosamide antibiotic, widely used treat variety It acts by inhibiting protein synthesis but, many antibiotics, also unintended consequences for human gut health. represents complex connection where clindamycin, can significantly alter microbiota, leading imbalances manifest diarrhea, abdominal other digestive issues. explore these depth comparing two common 300 mg versus 600 mg, each dose severity duration effects. Materials methods involves 45 patients prescribed various were evaluated groups: 22 who received 23 mg. Treatment ranged from seven 10 days. Data collection focused patient-reported symptoms, including presence length episodes, persistence overall Statistical analysis included independent t-tests compare symptom between groups chi-squared tests assess differences incidence while regression was examine predictors prolonged symptoms. Results results showed 98% experienced some clindamycin. Among receiving dose, frequency higher compared group. Specifically, average group five days, three days Similarly, pain four taking lower dose. Chi-squared indicated association increased Regression further predictor disturbances, underscoring dose-dependent relationship. Conclusion findings case highlight at doses, associated pain. Almost all suffering more severe symptoms suggest avoiding prescription unless absolutely necessary, reduce outcomes improve compliance. recommended prioritize first-line reserve secondary option. Further research needed investigate strategies prescribing.

Language: Английский

Longitudinal Analysis of Tooth Loss as a Biomarker of Systemic Health: Insights From a 15-Year Study of 35 Patients DOI Open Access

Elizabeth Litvinov,

Alexander V. Litvinov

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 2, 2025

Introduction Tooth loss, often perceived as a localized dental issue, has profound implications for systemic health. It is frequently associated with underlying factors such periodontal disease, smoking, poor dietary habits, and psychological stress. These contribute to tooth loss locally are linked various conditions, including diabetes cardiovascular disease. This study explores the predictive value of biomarker health emphasizing its potential serve an early warning indicator broader risks highlighting interconnected nature oral Background The interconnection between received significant attention in recent years. Chronic particularly inflammation, key factor development diseases atherosclerosis diabetes. resulting from severe pathology, reflects history chronic hygiene, adverse lifestyle choices. Despite clinical relevance, remains underutilized marker status. seeks address this gap by evaluating trajectories patients over 15-year period. Materials methods retrospectively analyzed chart records 35 who experienced (321 teeth total) due age, deficiencies, stress, bruxism, fractures, infections. Medical spanning period were reviewed monitor progression conditions. Statistical analyses, correlation logistic regression, performed evaluate relationships outcomes. Kaplan-Meier survival analysis assessed time disease onset relation deterioration. A score prediction equation was developed. Results findings revealed that strongly conditions diabetes, respiratory disorders. positive observed (r = 0.72, p < 0.01) 0.68, 0.01). Logistic regression demonstrated had significantly higher odds developing (OR 3.5) 2.8). curves indicated extensive earlier than those minimal (median time: 7 vs. 12 years, 0.03). Smoking, diet, stress emerged exacerbating factors. Conclusions reflecting cumulative effects factors, highlights importance integrating medical care root causes both diseases. Proactive interventions, prevention strategies, can improve overall Further research involving larger cohorts recommended validate enhance models application.

Language: Английский

Citations

0
Unveiling the Molecular Crosstalk Between Periodontal and Cardiovascular Diseases: A Systematic Review DOI Creative Commons
Gunaraj Dhungana, Dollada Srisai, Chethan Sampath

et al.

Dentistry Journal, Journal Year: 2025, Volume and Issue: 13(3), P. 98 - 98

Published: Feb. 25, 2025

Background/Objectives: Periodontal disease (PD) is a chronic inflammatory condition caused by dysbiosis of the oral microbiome. PD linked to systemic inflammation and endothelial dysfunction, which associate it with cardiovascular (CVD). This systematic review explores molecular microbial mechanisms through periodontal pathogens, including “Red Complex” bacteria (Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola) Fusobacterium nucleatum, influence health via pathways, immune modulation, dissemination. Methods: A was conducted following PRISMA guidelines. literature search in PubMed ScienceDirect databases using relevant keywords, strict inclusion exclusion criteria, from first week September 2024 October 2024. Studies addressing relationship between CVD were assessed for methodological rigor, relevance, data availability. The outcomes synthesized descriptive narrative approach. Out 591 records screened, 421 full-text articles sought retrieval. final included 58 providing supplementary aggregated after eligibility assessment. Results: pathogenesis involves activation cells release pro-inflammatory cytokines (such as IL-1, IL-6, TNF-α, PGE2) chemokines (including IL-8 MCP-1) along oxidative stress driven reactive oxygen species (ROS). pathogens trigger Toll-like receptors (TLRs), NF-κB signaling, nitric oxide (NO) dysregulation, contributing dysfunction atherogenesis. Biomarkers, such C-reactive protein, interleukins, matrix metalloproteinases (MMPs), further highlight response. Conclusions: underscores significant role mediators health, particularly progression CVD. Although existing evidence illustrates these associations, underlying remain inadequately understood, indicating need research advance precision medicine therapeutic strategies.

Language: Английский

Citations

0
Impact of Clindamycin on the Oral-Gut Axis: Gastrointestinal Side Effects and Clostridium difficile Infection in 45 Patients DOI Open Access

Elizabeth Litvinov,

Alexander V. Litvinov

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

Introduction The use of antibiotics such as oral clindamycin has been effective in treating bacterial infections. However, this medication often comes with significant side effects, particularly those affecting the gastrointestinal (GI) system. This study aims to evaluate impact different doses on GI health, specifically examining effects like stomach upset, diarrhea duration, pain, and recovery time. Given that is frequently prescribed, understanding its oral-gut axis critical optimizing antibiotic therapy reducing adverse events. Background Clindamycin, a lincosamide antibiotic, widely used treat variety It acts by inhibiting protein synthesis but, many antibiotics, also unintended consequences for human gut health. represents complex connection where clindamycin, can significantly alter microbiota, leading imbalances manifest diarrhea, abdominal other digestive issues. explore these depth comparing two common 300 mg versus 600 mg, each dose severity duration effects. Materials methods involves 45 patients prescribed various were evaluated groups: 22 who received 23 mg. Treatment ranged from seven 10 days. Data collection focused patient-reported symptoms, including presence length episodes, persistence overall Statistical analysis included independent t-tests compare symptom between groups chi-squared tests assess differences incidence while regression was examine predictors prolonged symptoms. Results results showed 98% experienced some clindamycin. Among receiving dose, frequency higher compared group. Specifically, average group five days, three days Similarly, pain four taking lower dose. Chi-squared indicated association increased Regression further predictor disturbances, underscoring dose-dependent relationship. Conclusion findings case highlight at doses, associated pain. Almost all suffering more severe symptoms suggest avoiding prescription unless absolutely necessary, reduce outcomes improve compliance. recommended prioritize first-line reserve secondary option. Further research needed investigate strategies prescribing.

Language: Английский

Citations

1