Feline bocaviruses found in Thailand have undergone genetic recombination for their evolutions DOI Creative Commons
Pattiya Lohavicharn, Tanit Kasantikul,

Chutchai Piewbang

et al.

Infection Genetics and Evolution, Journal Year: 2024, Volume and Issue: 125, P. 105675 - 105675

Published: Sept. 27, 2024

Feline bocaviruses (FBoVs) have been discovered for a decade and are often detected in feces, possibly associated with diarrhea cats. Studies on FBoV evolution remain limited mainly focused prevalence genetic characterization. Although recombination serves as potential mechanism bocavirus evolution, research this process FBoVs has scarce. In study, we characterized 19 complete coding sequences of obtained from Thai cats, revealing that FBoV-1, -2, -3 were endemic Thailand. Genetic characterizations showed most closely related to previously strains Thailand China. Recombination analyses indicated intragenic, intraspecies all species, breakpoints commonly found the NP1 VP1/2 genes, highlighting these genes may be hotspots recombination. However, no interspecies was detected. Selective pressure analysis various revealed viruses underwent purifying selection. gene species under strongest negative selection pressure, positive sites only FBoV-1 FBoV-3. This study is first identify natural FBoV-2 FBoV-3 provides evidence driver evolutions. Additionally, offers up-to-date information characteristics, evolutionary dynamics, selective status FBoVs, which should continuously monitored.

Language: Английский

Feline bocaviruses found in Thailand have undergone genetic recombination for their evolutions DOI Creative Commons
Pattiya Lohavicharn, Tanit Kasantikul,

Chutchai Piewbang

et al.

Infection Genetics and Evolution, Journal Year: 2024, Volume and Issue: 125, P. 105675 - 105675

Published: Sept. 27, 2024

Feline bocaviruses (FBoVs) have been discovered for a decade and are often detected in feces, possibly associated with diarrhea cats. Studies on FBoV evolution remain limited mainly focused prevalence genetic characterization. Although recombination serves as potential mechanism bocavirus evolution, research this process FBoVs has scarce. In study, we characterized 19 complete coding sequences of obtained from Thai cats, revealing that FBoV-1, -2, -3 were endemic Thailand. Genetic characterizations showed most closely related to previously strains Thailand China. Recombination analyses indicated intragenic, intraspecies all species, breakpoints commonly found the NP1 VP1/2 genes, highlighting these genes may be hotspots recombination. However, no interspecies was detected. Selective pressure analysis various revealed viruses underwent purifying selection. gene species under strongest negative selection pressure, positive sites only FBoV-1 FBoV-3. This study is first identify natural FBoV-2 FBoV-3 provides evidence driver evolutions. Additionally, offers up-to-date information characteristics, evolutionary dynamics, selective status FBoVs, which should continuously monitored.

Language: Английский

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