Neisseria Gonorrhoeae: Its Dominant Properties to Establish Contact and Attachment that Facilitate Epithelial Invasion and Colonization From a Biochemist Perspective DOI Open Access
Trini Suryowati

Asian Journal of Biochemistry Genetics and Molecular Biology, Journal Year: 2023, Volume and Issue: 15(3), P. 82 - 90

Published: Nov. 2, 2023

Aim: to discuss recent epidemiology of gonorrhoea and updates regarding its pathogenesis with a focus on biochemical aspects contact adhesion that preceded epithelial invasion. Discussion: Neisseria gonorrhoeae, Gram-negative obligate human pathogenic bacterium, infects cells causes sexually transmitted diseases in both males females Gonorrhea rates are rising many countries. It could lead long-term health problems even infertility. Vulnerable groups including men who have sex workers appear bear disproportionate burdens gonorrhea. As N. gonorrhoeae advances through the steps disease formation (transmission, adherence, colonization invasion, also immune evasion), bacterium expresses some virulence factors facilitate survival replication; while at same time keeping existence barely invasive almost undiscoverable by active cells. Adherence becomes first event precedes Conclusion: Adhesion gonococci mucosal appears be critical step gonococcal infection. Gonococci can adhere variety has multiple surface proteins adhesion. utilize type IV pili Opa, opacity-associated proteins, involved cellular attachment Lipooligosaccharides (LOS) outer membrane protein porin (POrB).

Language: Английский

Neisseria Gonorrhoeae: Its Dominant Properties to Establish Contact and Attachment that Facilitate Epithelial Invasion and Colonization From a Biochemist Perspective DOI Open Access
Trini Suryowati

Asian Journal of Biochemistry Genetics and Molecular Biology, Journal Year: 2023, Volume and Issue: 15(3), P. 82 - 90

Published: Nov. 2, 2023

Aim: to discuss recent epidemiology of gonorrhoea and updates regarding its pathogenesis with a focus on biochemical aspects contact adhesion that preceded epithelial invasion. Discussion: Neisseria gonorrhoeae, Gram-negative obligate human pathogenic bacterium, infects cells causes sexually transmitted diseases in both males females Gonorrhea rates are rising many countries. It could lead long-term health problems even infertility. Vulnerable groups including men who have sex workers appear bear disproportionate burdens gonorrhea. As N. gonorrhoeae advances through the steps disease formation (transmission, adherence, colonization invasion, also immune evasion), bacterium expresses some virulence factors facilitate survival replication; while at same time keeping existence barely invasive almost undiscoverable by active cells. Adherence becomes first event precedes Conclusion: Adhesion gonococci mucosal appears be critical step gonococcal infection. Gonococci can adhere variety has multiple surface proteins adhesion. utilize type IV pili Opa, opacity-associated proteins, involved cellular attachment Lipooligosaccharides (LOS) outer membrane protein porin (POrB).

Language: Английский

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