На основании анализа данных литературы изложены современные представления об изменениях функционирования эндокринной регуляции, происходящих под влиянием различных факторов внешней среды. Показано, что гипоталамо-гипофизарно-гонадная и тиреоидная ось эндокринной регуляции наряду с симпатоадреналовым и гипоталамо-гипофизарно-надпочечниковым звеном играют важнейшую роль в ответ на экстремальные воздействия внешней среды и адаптацию организма. При этом в механизмах поддержания гомеостаза организма изменения гормональной секреции представляют собой своеобразный каскад тесно взаимосвязанных реакций. Изучение этих механизмов и выяснение их роли в патогенезе вызываемых нарушений — фундаментальная проблема биомедицинских исследований. Ее решение позволит совершенствовать способы профилактики и лечения заболеваний, обусловленных стрессом.
Psychology and Law,
Journal Year:
2024,
Volume and Issue:
14(1), P. 235 - 247
Published: April 4, 2024
<p
style="text-align:
justify;">The
article
presents
a
review
of
psychophysiological
and
psychoendocrine
approaches
in
foreign
studies
stress
response
police
officers.
The
main
vectors
to
representatives
dangerous
professions
are
identified.
It
has
been
determined
that,
combination
with
the
autonomic
nervous
immune
systems,
hypothalamic
pituitary
adrenal
axis
is
involved
formation
an
individual
chronic
stress.
emphasis
works
devoted
study
component
officers
influence
dehydroepiandrosterone
cortisol.
Modern
technologies
for
recording
indicators
was
also
being
studied.
Further
from
point
view
their
integration
seems
promising.</p>
Sel skokhozyaistvennaya Biologiya,
Journal Year:
2024,
Volume and Issue:
59(2), P. 301 - 315
Published: April 1, 2024
КОРТИЗОЛ
КАК
МАРКЕР
ФИЗИОЛОГИЧЕСКОГО
СТРЕССА
У
БЫКОВ-ПРОИЗВОДИТЕЛЕЙ
(Bos
taurus)
А.И.АБИЛОВ
1
,
А.А.ГУДИЛИНА
Н.А.КОМБАРОВА
2
В.В.ТУРБИНА
Ю.А.КОРНЕЕНКО-ЖИЛЯЕВ
Эндокринный
механизм
стресса
у
животных
до
сих
пор
окончательно
не
выяснен.Социальный
стресс
из-за
иерархии
в
стаде
увеличивает
выработку
кортизола,
катехоламинов,
может
влиять
на
половое
поведение
и
фертильность,
снижать
продуктивность.Несмотря
огромное
значение
проблемы
для
племенных
предприятий,
занимающихся
получением
криоконсервацией
спермы
сельскохозяйственных
коммерческих
научных
целях,
нет
специальных
исследований,
посвященных
связи
качественных
количественных
характеристик
эякулята
оплодотворяющей
способности
сперматозоидов
с
уровнем
постэякулятивного
кортизола.В
представленной
работе
мы
впервые
показали,
что
результативность
искусственного
осеменения
прямо
пропорциональна
концентрации
кортизола
сыворотке
крови
быков-производителей
после
эякуляции.У
молодых
доминировал
стресс,
связанный
взятием
крови,
взрослых
особей
возбуждение
подавляло
от
этой
ветеринарной
манипуляции.Впервые
выявлена
зависимость
крупного
рогатого
скота
уровня
эякуляции.Мы
определили
динамику
11
голштинской
породы
иностранной
селекции
возрасте
29-71
мес
(холдинг
АО
«ГЦВ»,
дочернее
племенное
предприятие
«Уралплемцентр»,
Свердловская
обл.,
2018-2021
годы)
эякуляции
при
периодичности
получения
семени
согласно
установленной
технологии
оценили
влияние
оплодотворяющую
способность
полученных
их
криоконсервации.Как
молодых,
так
достоверная
положительная
динамика
ежесуточных
ветеринарных
манипуляциях
по
взятию
течение
эксперимента.Средняя
концентрация
производителей
(n
=
6)
условиях
стресса,
вызванного
этими
регулярными
манипуляциями,
увеличивалась
равномерно
дни
трех
последовательных
дуплетных
взятий
4-5-суточными
интервалами
составила
70,8;
91,1
144,7
нмоль/л.У
быков
5)
старше
4
лет
максимальный
уровень
(172,5
нмоль/л)
зафиксирован
второго
взятия
семени,
а
к
третьему
отмечалось
его
незначительное
снижение
(на
5
%).С
ростом
увеличивается
количество
выделенных
сперматозоидов.У
за
одну
эякуляцию
получили
соответственно
4,0;
5,5
6,2
млрд
сперматозоидов,
-6,6;
7,3
7,5
сперматозоидов.При
оценке
зависимости
лучшие
результаты
(59-60
%,
р
<
0,001)
дали
замороженные
спермодозы
из
эякулятов,
получение
которых
сопровождалось
значительным
выбросом
кровяное
русло
(концентрацией
162-216
нмоль/л).
Сибирский научный медицинский журнал,
Journal Year:
2024,
Volume and Issue:
44(5), P. 88 - 94
Published: Oct. 30, 2024
The
aim
of
the
work
is
to
compare
reaction
pituitary-gonadal
system
and
cortisol
content
in
two
types
dopaminergic
reactions
male
residents
Arkhangelsk
at
change
photoperiod
during
year.
Material
methods
.
During
one
year,
a
four-time
examination
was
conducted
(in
March,
June,
September,
December)
20
practically
healthy
males
(average
age
33.3
±
5.3
years).
concentration
dopamine
determined
blood
plasma,
components
level
were
studied
serum.
Based
on
analysis
individual
reactions,
sample
divided
into
groups:
1
–
subjects
increases
December
compared
with
September
(n
=
10);
2
decreases
or
does
not
10).
Results.
In
group
1,
decrease
testosterone
levels
revealed:
both
total
(18.16
nmol/l
25.20
September)
free
(3.77
4.29
pg/ml,
respectively)
fractions.
At
same
time,
higher
noted
first
second
(574.22
502.69
nmol/l,
respectively).
2,
there
significant
estradiol
(0.13
nmol/L
versus
0.31
an
increase
testosterone/estradiol
index
(173.82
54.01
units,
Conclusions.
individual-typological
variability
replacement
photoperiods
living
European
North
may
have
indirect
effect
axis
through
parallel
activation
adrenal
cortex
increased
aromatase
activity.
We
assume
that
period
minimum
daylight
hours
plays
role
compensatory
adaptive
population
North.
Ekologiya Cheloveka (Human Ecology),
Journal Year:
2023,
Volume and Issue:
29(12), P. 889 - 900
Published: Jan. 5, 2023
BACKGROUND:
An
investigation
to
determine
the
reproductive
health
disorders
commonly
found
in
adolescent
females
residing
North
peninsula
of
Kola,
Russia.
Insubstantial
studies
on
physiological
status
aged
living
a
territory
that
has
become
highly
polluted
due
dust
particles
apatite-nepheline
ore,
determines
relevance
this
study
and
involves
identification
indicators
premorbid
state.
AIM:
To
examine
under
chronic
stress
condition
caused
by
exposure
both
anthropogenic
as
well
Arctic
environment
with
an
objective
reveal
possible
pre-nosological
deviations
MATERIAL
AND
METHODS:
We
conducted
observational,
longitudinal
analytic
"3
waves
panel
(2019,
2020,
2021)
involving
54
female
students
1620
years
old
from
medical
college
city
Apatity,
Physiological
was
assessed
accordance
content
hypothalamic-pituitary-adrenocortical
system
hormones,
metabolites
lipid
peroxidation,
antioxidant
protection,
vitamin
D,
lipids,
carbohydrates
using
percentile
distribution
indicator
values.
Significance
differences
determined
comparative
analysis
two
dependent
variables
Wilcoxon
criterion.
RESULTS:
Deviations
optimal
values
state
were
revealed
more
than
25%
females,
which
manifested
themselves
increased
secretion
adrenocorticotropic
hormone,
cortisol,
thyrotropic
depleting
somatotropic
thyroxine
reduced
protection
enzymes.
In
95%
hypovitaminosis
D
detected
whereas
50%
diminished
low-density
lipoproteins.
CONCLUSION:
Pre-nosological
conditions
technogenic
pollution
testify
oppression
bodys
protective
systems
are
predictors
morbidity
subject
individual
correction.
Health risk analysis,
Journal Year:
2022,
Volume and Issue:
unknown, P. 39 - 52
Published: Sept. 1, 2022
The
article
dwells
on
climatic
and
chemical
risk
factors
that
influence
health
of
people
living
in
the
RF
arctic
sub-arctic
regions
population
sub-population
levels.
We
used
a
model
describing
cause-effect
relations
between
environmental
life
expectancy
at
birth
based
an
artificial
neural
network
to
predict
future
medical
demographic
situation
territories
with
climate
RF.
Children’s
was
examined
profoundly
due
participating
representative
sampling.
comparatively
analyzed
clinical,
biochemical
general
clinical
indicators
test
reference
groups
using
standard
statistical
procedures
software
packages.
established
average
monthly
temperatures
July
grew
by
3.4
%
over
2010–2019
RF;
precipitations
January
13.0–15.1
%.
presents
differentiated
estimates
emerging
(LEB)
exerted
weather
conditions
climate.
Losses
LEB
vary
from
164
days
Yakutia
349
Chukotka.
Aggregated
zones
produced
variable
effects
LEB,
starting
negative
ones
resulted
its
decline
Magadan
region,
Nenets
Autonomous
Area,
Chukotka,
Yamal-Nenets
Area
(-254;
-211;
-109
-8
accordingly)
positive
led
growth
up
111
Yakutia.
Children
who
are
simultaneously
exposed
adverse
zone
substantial
pollution
ambient
air
have
more
frequent
apparent
changes
their
comparison
children
group.
Thus,
respiratory
diseases
nervous
system
were
5.6
times
group;
levels
leukocytes,
ESR,
TSH,
Apo-B
Apo-B/ApoA1
blood
1.3–1.7
higher,
р
=
0.0001.
Levels
Apo
A1,
hydrocortisone,
serotonin
1.2–2.5
lower,
0.0001–0.040,
etc.
A
share
contribution
made
associated
amounted
25–31
%;
factors,
10–15
.
Journal of Volgograd State Medical University,
Journal Year:
2022,
Volume and Issue:
19(1), P. 162 - 166
Published: Jan. 15, 2022
Introduction.
Sodium
benzoate
is
widely
used
in
both
food
and
pharmaceutical
industries.
There
evidence
of
its
adverse
health
effects;
However,
the
effect
sodium
on
ultrastructure
thyroid
gland
cells
currently
not
well
understood.
Materials
methods.
The
animals
were
divided
into
two
groups:
group
1
was
injected
with
ml
solution
at
a
dosage
1000
mg/kg/body
weight
intragastrically
for
60
days,
2
served
as
control.
Samples
after
tissue
processingwere
examined
under
an
electron
microscope.
Results.
In
experimental
group,
it
found
that
thyrocytes
had
cubic,
less
often
flat
shape,
expanded
rough
endoplasmic
reticulum
single
accumulations
cavities
fibrous
structures,
significant
lumps
heterochromatin
nuclear
membrane
uneven
contours
latter,
electron-dense
mitochondrial
matrix.
Conclusion.
above
changes
indicate
administration
locally
(through
damage
to
DNA
nucleus
mitochondria)
systemic
level
decrease
leptin
levels
and,
consequence,
hypothalamic-pituitary-thyroid
axis).
Wiadomości Lekarskie,
Journal Year:
2020,
Volume and Issue:
73(11), P. 2378 - 2385
Published: Jan. 1, 2020
The
aim:
Evaluation
of
stress-protective
effects
various
anesthetic
techniques
on
Cesarean
section
(CS).
Materials
and
methods:
127
pregnant
women
who
delivered
by
cesarean
section,
were
divided
into
4
subgroups:
1a
(n
=
31)
–
general
anesthesia
(GA)
with
ketamine,
1b
GA
sodium
thiopental,
2a
spinal
(SA),
2b
34)
SA
intravenous
administration
ondansetron
at
a
dose
8
mg.
assessment
was
performed
5
stages:
1
initial;
2
infant
extraction;
3
6
hours
after
surgery;
12
surgery.
Results:
At
stage
2,
insulin
levels
in
subgroups
decreased
23.9%
34.1%,
while
there
no
significant
changes.
There
an
increase
the
cortisol,
prolactin
cortisol/insulin
ratio
stages
subgroups.
Pain
intensity
increased
patients
all
groups.
It
highest
stage,
pain
reduced
groups,
remaining
significantly
higher
Conclusions:
dynamics
content
stress
hormones,
undergoing
CS
under
give
reason
to
consider
this
method
as
optimal
adequate
one
for
protection
from
surgery
stress.