Although the heat-stress response has been extensively studied for decades, very little is known about its effects on nucleic acids and nucleic acid-associated processes. This is due to the fact that the research has focused on the study of heat shock proteins and factors (HSPs and HSFs), their involvement in the regulation of transcription, protein homeostasis, etc. Recently, there has been some progress in the study of heat stress effects on DNA integrity. In this review, we summarize and discuss well-known and potential mechanisms of formation of various heat stress-induced DNA damage.
Insect Molecular Biology,
Journal Year:
2024,
Volume and Issue:
33(5), P. 432 - 443
Published: April 24, 2024
Agricultural
insect
pests
(AIPs)
are
widely
successful
in
adapting
to
natural
and
anthropogenic
stressors,
repeatedly
overcoming
population
bottlenecks
acquiring
resistance
intensive
management
practices.
Although
they
have
been
largely
overlooked
evolutionary
studies,
AIPs
ideal
systems
for
understanding
rapid
adaptation
under
novel
environmental
conditions.
Researchers
identified
several
genomic
mechanisms
that
likely
contribute
adaptive
stress
responses,
including
positive
selection
on
de
novo
mutations,
polygenic
standing
allelic
variation
phenotypic
plasticity
(e.g.,
hormesis).
However,
new
theory
suggests
itself
may
induce
epigenetic
modifications,
which
confer
heritable
physiological
changes
(i.e.,
stress-resistant
phenotypes).
In
this
perspective,
we
discuss
how
from
agricultural
generates
the
genetic
modifications
associated
with
AIPs.
We
summarise
existing
evidence
stress-induced
processes
context
of
insecticide
resistance.
Ultimately,
propose
studying
offers
opportunities
resources
advancing
our
knowledge
evolution.
PLoS Pathogens,
Journal Year:
2024,
Volume and Issue:
20(9), P. e1012471 - e1012471
Published: Sept. 5, 2024
Bats
are
natural
reservoirs
for
zoonotic
pathogens,
yet
the
determinants
of
microbial
persistence
as
well
specific
functionality
their
immune
system
remain
largely
enigmatic.
Their
propensity
to
harbor
viruses
lethal
humans
and/or
livestock,
mostly
in
absence
clinical
disease,
makes
bats
stand
out
among
mammals.
Defending
against
pathogens
relies
on
avoidance,
resistance,
tolerance
strategies.
In
bats,
disease
has
recently
gained
increasing
attention
a
prevailing
host
defense
paradigm.
We
here
summarize
current
knowledge
responses
context
infection
with
agents
and
discuss
concepts
related
tolerance.
Acknowledging
wide
diversity
broad
spectrum
bat-associated
species,
immune-related
gaps,
we
identify
research
priorities
necessary
provide
evidence-based
proofs
bats.
Since
networks
biological
processes,
emphasize
that
investigations
beyond
system,
using
novel
technologies
computational
biology,
could
jointly
advance
our
about
mechanisms
conferring
reservoir
abilities.
Although
may
not
be
“one
fit
all”
strategy,
deciphering
translate
into
therapies
inform
prevention
spillover
infections
livestock.
GigaScience,
Journal Year:
2020,
Volume and Issue:
9(2)
Published: Feb. 1, 2020
Abstract
Background
The
domestic
buffalo
(Bubalus
bubalis)
is
an
essential
farm
animal
in
tropical
and
subtropical
regions,
whose
genomic
diversity
yet
to
be
fully
discovered.
Results
In
this
study,
we
describe
the
demographic
events
selective
pressures
of
by
analyzing
121
whole
genomes
(98
newly
reported)
from
25
swamp
river
breeds.
Both
uniparental
biparental
markers
were
investigated
provide
final
scenario.
ancestors
diverged
~0.23
million
years
ago
then
experienced
independent
histories.
They
domesticated
different
at
border
between
southwest
China
southeast
Asia,
while
south
Asia.
stocks
migrated
other
regions
further
differentiated,
as
testified
(at
least)
2
ancestral
components
identified
each
subspecies.
Different
signals
also
detected
these
types
buffalo.
buffalo,
historically
used
a
draft
animal,
shows
selection
signatures
genes
associated
with
nervous
system,
dairy
breeds,
under
are
related
heat
stress
immunity.
Conclusions
Our
findings
substantially
expand
catalogue
genetic
variants
reveal
new
insights
into
evolutionary
history
distinct
