Immunity,
Год журнала:
2024,
Номер
57(5), С. 941 - 956
Опубликована: Май 1, 2024
Ferroptosis
is
a
type
of
regulated
cell
death
that
drives
the
pathophysiology
many
diseases.
Oxidative
stress
detectable
in
types
death,
but
only
ferroptosis
involves
lipid
peroxidation
and
iron
dependency.
originates
propagates
from
several
organelles,
including
mitochondria,
endoplasmic
reticulum,
Golgi,
lysosomes.
Recent
data
have
revealed
immune
cells
can
both
induce
undergo
ferroptosis.
A
mechanistic
understanding
how
regulates
immunity
critical
to
controls
responses
this
dysregulated
disease.
Translationally,
more
work
needed
produce
ferroptosis-modulating
immunotherapeutics.
This
review
focuses
on
role
immune-related
diseases,
infection,
autoimmune
cancer.
We
discuss
immunity,
regulation
contributes
disease
pathogenesis,
targeting
may
lead
novel
therapies.
Microbial
roles
in
cancer
formation,
diagnosis,
prognosis,
and
treatment
have
been
disputed
for
centuries.
Recent
studies
provocatively
claimed
that
bacteria,
viruses,
and/or
fungi
are
pervasive
among
cancers,
key
actors
immunotherapy,
engineerable
to
treat
metastases.
Despite
these
findings,
the
number
of
microbes
known
directly
cause
carcinogenesis
remains
small.
Critically
evaluating
building
frameworks
such
evidence
light
modern
biology
is
an
important
task.
In
this
Review,
we
delineate
between
causal
complicit
trace
common
themes
their
influence
through
host's
immune
system,
herein
defined
as
immuno-oncology-microbiome
axis.
We
further
review
intratumoral
approaches
manipulate
gut
or
tumor
microbiome
while
projecting
next
phase
experimental
discovery.
Biomedicine & Pharmacotherapy,
Год журнала:
2021,
Номер
139, С. 111619 - 111619
Опубликована: Апрель 24, 2021
Following
cancer,
cells
in
a
particular
tissue
can
no
longer
respond
to
the
factors
involved
controlling
cell
survival,
differentiation,
proliferation,
and
death.
In
recent
years,
it
has
been
indicated
that
alterations
gut
microbiota
components,
intestinal
epithelium,
host
immune
system
are
associated
with
cancer
incidence.
Also,
demonstrated
short-chain
fatty
acids
(SCFAs)
generated
by
vitally
crucial
homeostasis
as
they
contribute
modulation
of
histone
deacetylases
(HDACs),
resulting
effected
attachment,
immigration,
cytokine
production,
chemotaxis,
programmed
Therefore,
manipulation
SCFA
levels
tract
structure
be
potentially
taken
into
consideration
for
treatment/prevention.
current
study,
we
will
explain
most
findings
on
detrimental
or
protective
roles
SFCA
(particularly
butyrate,
propionate,
acetate)
several
cancers,
including
bladder,
colon,
breast,
stomach,
liver,
lung,
pancreas,
prostate
cancers.
Journal of Hematology & Oncology,
Год журнала:
2022,
Номер
15(1)
Опубликована: Апрель 29, 2022
The
gut
microbiota
have
long
been
recognized
to
play
a
key
role
in
human
health
and
disease.
Currently,
several
lines
of
evidence
from
preclinical
clinical
research
gradually
established
that
the
can
modulate
antitumor
immunity
affect
efficacy
cancer
immunotherapies,
especially
immune
checkpoint
inhibitors
(ICIs).
Deciphering
underlying
mechanisms
reveals
reprogram
tumor
microenvironment
(TME)
by
engaging
innate
and/or
adaptive
cells.
Notably,
one
primary
modes
which
is
means
metabolites,
are
small
molecules
could
spread
their
initial
location
impact
local
systemic
response
promote
ICI
efficiency.
Mechanistic
exploration
provides
novel
insights
for
developing
rational
microbiota-based
therapeutic
strategies
manipulating
microbiota,
such
as
fecal
transplantation
(FMT),
probiotics,
engineered
microbiomes,
specific
microbial
augment
advance
age
utilization
precision
medicine.
Theranostics,
Год журнала:
2021,
Номер
11(9), С. 4155 - 4170
Опубликована: Янв. 1, 2021
Background:
Anti-PD-1-based
immunotherapy
has
emerged
as
a
promising
therapy
for
several
cancers.
However,
it
only
benefits
small
subset
of
colorectal
cancer
(CRC)
patients.
Mounting
data
supports
the
pivotal
role
gut
microbiota
in
shaping
immune
system.
Pectin,
widely
consumed
soluble
fiber,
been
reported
to
ameliorate
imbalance
microbiota.
Therefore,
we
aimed
explore
effect
and
underlying
mechanisms
pectin
improving
anti-PD-1
mAb
efficacy.
Methods:
The
C57BL/6
mice
were
treated
with
broad-spectrum
antibiotic
(ATB)
cocktail
depleted
endogenous
subsequently
humanized
feces
from
healthy
controls
or
newly
diagnosed
CRC
antitumor
efficacies
combined
without
assessed
using
these
mice.
Flow
cytometry
immunohistochemistry
(IHC)
conducted
investigate
tumor
microenvironment
after
treatment.
profiles
short-chain
fatty
acids
(SCFAs)
levels
determined
by
16S
ribosomal
RNA
(16S
rRNA)
gene
sequencing
gas
chromatography-mass
spectrometry
(GC-MS),
respectively.
on
efficacy
supplement
was
further
tested
fecal
transplantation
(FMT).
Results:
largely
impaired
patients
compared
those
controls.
significantly
enhanced
tumor-bearing
patient
IHC
analysis
revealed
increased
T
cell
infiltration
activation
plus
pectin.
In
vivo
depletion
CD8+
cells
diminished
anti-tumor
rRNA
showed
that
microbial
diversity
beneficially
regulated
composition.
addition,
identified
unique
bacterial
modules
enriched
+
group,
which
composed
butyrate-producing
bacteria
indicative
good
response
immunotherapy.
Meanwhile,
GC-MS
altered
level
SCFA
butyrate.
Furthermore,
butyrate,
main
product
dietary
fiber
fermentation,
found
be
sufficient
promote
thus
enhance
mAb.
FMT
demonstrated
effects
dependent
Importantly,
beneficial
confirmed
resistance
Conclusion:
Pectin
facilitated
via
regulating
microenvironment,
potentially
mediated
metabolite
