2D Catalytic Nanozyme Enables Cascade Enzyodynamic Effect‐Boosted and Ca2+ Overload‐Induced Synergistic Ferroptosis/Apoptosis in Tumor DOI
Zeyu Wang, Xue Wang, Xinyue Dai

и другие.

Advanced Materials, Год журнала: 2024, Номер 36(24)

Опубликована: Март 19, 2024

Abstract The introduction of glucose oxidase, exhibiting characteristics consumption and H 2 O production, represents an emerging antineoplastic therapeutic approach that disrupts nutrient supply promotes efficient generation reactive oxygen species (ROS). However, the instability natural enzymes their low efficacy significantly impede broader application. In this context, 2D Ca Mn 8 16 nanosheets (CMO NSs) designed engineered to serve as a high‐performance nanozyme, enhancing enzyodynamic effect for ferroptosis–apoptosis synergistic tumor therapy, are presented. addition mimicking activities glutathione peroxidase, catalase, CMO NSs exhibit oxidase‐mimicking activities. This feature contributes antitumor performance through cascade catalytic reactions, involving disruption supply, self‐supply , subsequent ROS generation. exogenous 2+ released from NSs, along with endogenous enrichment induced by peroxidase‐ collectively mediate overload, leading apoptosis. Importantly, ferroptosis process is triggered synchronously output consumption. application ultrasound stimulation further enhances efficiency treatment. work underscores crucial role in therapy against tumors.

Язык: Английский

Review on Recent Progress in Magnetic Nanoparticles: Synthesis, Characterization, and Diverse Applications DOI Creative Commons
Arbab Ali, Tufail Shah, Rehmat Ullah

и другие.

Frontiers in Chemistry, Год журнала: 2021, Номер 9

Опубликована: Июль 13, 2021

Diverse applications of nanoparticles (NPs) have revolutionized various sectors in society. In the recent decade, particularly magnetic (MNPs) gained enormous interest owing to their specialized areas such as medicine, cancer theranostics, biosensing, catalysis, agriculture, and environment. Controlled surface engineering for design multi-functional MNPs is vital achieving desired application. The demonstrated great efficacy thermoelectric materials, imaging agents, drug delivery vehicles, biosensors. present review, first we briefly discussed main synthetic methods MNPs, followed by characterizations composition. Then potential different with representative examples. At end, gave an overview on current challenges future prospects MNPs. This comprehensive review not only provides mechanistic insight into synthesis, functionalization, application but also outlines limits prospects.

Язык: Английский

Процитировано

491

Tumor-associated macrophages in cancer: recent advancements in cancer nanoimmunotherapies DOI Creative Commons
Nisha Kumari, Seung Hong Choi

Journal of Experimental & Clinical Cancer Research, Год журнала: 2022, Номер 41(1)

Опубликована: Фев. 19, 2022

Abstract Cancer immunotherapy has emerged as a novel cancer treatment, although recent trials have produced suboptimal outcomes, with durable responses seen only in small number of patients. The tumor microenvironment (TME) been shown to be responsible for immune escape and therapy failure. vital component the TME is tumor-associated macrophages (TAMs), which are usually associated poor prognosis drug resistance, including immunotherapies, promising targets immunotherapy. Recently, nanoparticles, because their unique physicochemical characteristics, crucial translational moieties tackling tumor-promoting TAMs that amplify sensitize tumors immunotherapies safe effective manner. In this review, we mainly described current potential nanomaterial-based therapeutic strategies target TAMs, restricting survival, inhibiting recruitment functionally repolarizing tumor-supportive antitumor type. understanding origin polarization role progression prognostic significance was also discussed review. We highlighted evolution chimeric antigen receptor (CAR)-macrophage cell therapy.

Язык: Английский

Процитировано

222

Metal nanoparticles as a promising technology in targeted cancer treatment DOI Creative Commons
Jiajie Xu,

Wan-Chen Zhang,

Yawen Guo

и другие.

Drug Delivery, Год журнала: 2022, Номер 29(1), С. 664 - 678

Опубликована: Фев. 25, 2022

Traditional anticancer treatments have several limitations, but cancer is still one of the deadliest diseases. As a result, new drugs are required for treatment cancer. The use metal nanoparticles (NPs) as alternative chemotherapeutic on rise in research. Metal NPs potential wide range applications. Natural or surface-induced effects can be found metals. focus this review therapeutic metal-based NPs. various types tumor targeting will discussed treatment.

Язык: Английский

Процитировано

187

Green Synthesis of Gold Nanoparticles Using Plant Extracts as Beneficial Prospect for Cancer Theranostics DOI Creative Commons
Kaushik Kumar Bharadwaj, Bijuli Rabha, Siddhartha Pati

и другие.

Molecules, Год журнала: 2021, Номер 26(21), С. 6389 - 6389

Опубликована: Окт. 22, 2021

Gold nanoparticles (AuNPs) have been widely explored and are well-known for their medical applications. Chemical physical synthesis methods a way to make AuNPs. In any case, the hunt other more ecologically friendly cost-effective large-scale technologies, such as environmentally biological processes known green synthesis, has gaining interest by worldwide researchers. The international focus on nanotechnology research resulted in various nanomaterials being used physiologically acceptable Several advantages over conventional chemical (simple, one-step approach synthesize, cost-effectiveness, energy efficiency, biocompatibility) drawn scientists’ attention exploring of AuNPs exploiting plants’ secondary metabolites. Biogenic approaches, mainly plant-based metal nanoparticles, chosen ideal strategy due environmental vivo safety, well ease synthesis. this review, we reviewed use synthesized treatment cancer utilizing phytochemicals found plant extracts. This article reviews producing AuNPs, characterization discusses physiochemical properties. study also recent breakthroughs achievements using different mechanisms action, reactive oxygen species (ROS), mediated mitochondrial dysfunction caspase activation, leading apoptosis, etc., anticancer cytotoxic effects. Understanding underlying therapeutic efficacy will aid developing personalized medicines treatments potential strategy.

Язык: Английский

Процитировано

177

Core–Shell Nanomaterials for Microwave Absorption and Electromagnetic Interference Shielding: A Review DOI
Yudhajit Bhattacharjee, Suryasarathi Bose

ACS Applied Nano Materials, Год журнала: 2021, Номер 4(2), С. 949 - 972

Опубликована: Фев. 11, 2021

Core–shell nanoparticles are a unique class of nanostructured materials, which received significant attention in the last two decades owing to their exciting properties and wide variety applications. By judiciously tuning "core" as well "shell", an assortment "core–shell" nanostructures can be obtained with tailorable play pivotal roles designing materials for electromagnetic interference (EMI) shielding microwave absorption. In recent times when use high-end electronics has been on rise, pollution is inevitable it affects every walk life. Among numerous e-pollutions, recently highlighted domain that far-reaching consequences interference. EMI disturbance created during electronic device's operation vicinity field caused by another or electric device. Since decreases lifetime degrades performance instruments even human health, crucial protect sophisticated components from EM High-performance shields capable attenuating propagation efficiently have developed past decade. Herein, this review, we attempted provide logical guide various (≤500 nm) synthesized decade application absorption shielding. The prime focus review article highlight fundamental concept reported systems literature along synthetic fabrication strategies suitable broadband absorbers/screeners. Finally, also made effort holistic outlook perspective upcoming research will continue flourish.

Язык: Английский

Процитировано

161

Nanoplatform-based cascade engineering for cancer therapy DOI
Jiajie Chen, Yufang Zhu, Chengtie Wu

и другие.

Chemical Society Reviews, Год журнала: 2020, Номер 49(24), С. 9057 - 9094

Опубликована: Янв. 1, 2020

This review provides a comprehensive overview of the recent advances in nanoplatform-based cascade engineering for cancer therapy, by concentrating on design smart nanoplatforms and implementation specific processes.

Язык: Английский

Процитировано

156

Magnetic-responsive hydrogels: From strategic design to biomedical applications DOI
Zhenguang Li, Yingze Li, Chang Chen

и другие.

Journal of Controlled Release, Год журнала: 2021, Номер 335, С. 541 - 556

Опубликована: Июнь 11, 2021

Язык: Английский

Процитировано

150

Multifunctional mesoporous silica nanoparticles for biomedical applications DOI Creative Commons
Bolong Xu, Shanshan Li, Rui Shi

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Ноя. 24, 2023

Abstract Mesoporous silica nanoparticles (MSNs) are recognized as a prime example of nanotechnology applied in the biomedical field, due to their easily tunable structure and composition, diverse surface functionalization properties, excellent biocompatibility. Over past two decades, researchers have developed wide variety MSNs-based nanoplatforms through careful design controlled preparation techniques, demonstrating adaptability various application scenarios. With continuous breakthroughs MSNs fields biosensing, disease diagnosis treatment, tissue engineering, etc., gradually moving from basic research clinical trials. In this review, we provide detailed summary beginning with comprehensive overview development history. We then discuss types nanostructured architectures, well classification nanocomposites according elements existed inorganic functional components. Subsequently, summarize primary purposes surface-functionalized modifications MSNs. following, applications MSNs, highlight targeted therapeutic modalities currently developed. Given importance translation, also progress Finally, take perspective on future direction remaining challenges field.

Язык: Английский

Процитировано

138

Cancer nanomedicine: a review of nano-therapeutics and challenges ahead DOI Creative Commons
M. Joyce Nirmala, Uma Kizhuveetil, Athira Johnson

и другие.

RSC Advances, Год журнала: 2023, Номер 13(13), С. 8606 - 8629

Опубликована: Янв. 1, 2023

Cancer is known as the most dangerous disease in world terms of mortality and lack effective treatment. Research on cancer treatment still active great social importance. Since 1930, chemotherapeutics have been used to treat cancer. However, such conventional treatments are associated with pain, side effects, a targeting. Nanomedicines an emerging alternative due their targeting, bioavailability, low toxicity. Nanoparticles target cells via passive mechanisms. FDA approval for Doxil®, several nano-therapeutics developed, few received use Along liposomes, solid lipid nanoparticles, polymeric nanoemulsions, even newer techniques involving extracellular vesicles (EVs) thermal nanomaterials now being researched implemented practice. This review highlights evolution current status therapy, focus clinical/pre-clinical nanomedicine studies. Insight also provided into prospects this regard.

Язык: Английский

Процитировано

111

Liposomes containing nanoparticles: preparation and applications DOI
Vincenzo De Leo, Anna Maria Maurelli, Livia Giotta

и другие.

Colloids and Surfaces B Biointerfaces, Год журнала: 2022, Номер 218, С. 112737 - 112737

Опубликована: Июль 28, 2022

Язык: Английский

Процитировано

110