Advanced Materials,
Год журнала:
2024,
Номер
36(24)
Опубликована: Март 19, 2024
Abstract
The
introduction
of
glucose
oxidase,
exhibiting
characteristics
consumption
and
H
2
O
production,
represents
an
emerging
antineoplastic
therapeutic
approach
that
disrupts
nutrient
supply
promotes
efficient
generation
reactive
oxygen
species
(ROS).
However,
the
instability
natural
enzymes
their
low
efficacy
significantly
impede
broader
application.
In
this
context,
2D
Ca
Mn
8
16
nanosheets
(CMO
NSs)
designed
engineered
to
serve
as
a
high‐performance
nanozyme,
enhancing
enzyodynamic
effect
for
ferroptosis–apoptosis
synergistic
tumor
therapy,
are
presented.
addition
mimicking
activities
glutathione
peroxidase,
catalase,
CMO
NSs
exhibit
oxidase‐mimicking
activities.
This
feature
contributes
antitumor
performance
through
cascade
catalytic
reactions,
involving
disruption
supply,
self‐supply
,
subsequent
ROS
generation.
exogenous
2+
released
from
NSs,
along
with
endogenous
enrichment
induced
by
peroxidase‐
collectively
mediate
overload,
leading
apoptosis.
Importantly,
ferroptosis
process
is
triggered
synchronously
output
consumption.
application
ultrasound
stimulation
further
enhances
efficiency
treatment.
work
underscores
crucial
role
in
therapy
against
tumors.
Frontiers in Chemistry,
Год журнала:
2021,
Номер
9
Опубликована: Июль 13, 2021
Diverse
applications
of
nanoparticles
(NPs)
have
revolutionized
various
sectors
in
society.
In
the
recent
decade,
particularly
magnetic
(MNPs)
gained
enormous
interest
owing
to
their
specialized
areas
such
as
medicine,
cancer
theranostics,
biosensing,
catalysis,
agriculture,
and
environment.
Controlled
surface
engineering
for
design
multi-functional
MNPs
is
vital
achieving
desired
application.
The
demonstrated
great
efficacy
thermoelectric
materials,
imaging
agents,
drug
delivery
vehicles,
biosensors.
present
review,
first
we
briefly
discussed
main
synthetic
methods
MNPs,
followed
by
characterizations
composition.
Then
potential
different
with
representative
examples.
At
end,
gave
an
overview
on
current
challenges
future
prospects
MNPs.
This
comprehensive
review
not
only
provides
mechanistic
insight
into
synthesis,
functionalization,
application
but
also
outlines
limits
prospects.
Journal of Experimental & Clinical Cancer Research,
Год журнала:
2022,
Номер
41(1)
Опубликована: Фев. 19, 2022
Abstract
Cancer
immunotherapy
has
emerged
as
a
novel
cancer
treatment,
although
recent
trials
have
produced
suboptimal
outcomes,
with
durable
responses
seen
only
in
small
number
of
patients.
The
tumor
microenvironment
(TME)
been
shown
to
be
responsible
for
immune
escape
and
therapy
failure.
vital
component
the
TME
is
tumor-associated
macrophages
(TAMs),
which
are
usually
associated
poor
prognosis
drug
resistance,
including
immunotherapies,
promising
targets
immunotherapy.
Recently,
nanoparticles,
because
their
unique
physicochemical
characteristics,
crucial
translational
moieties
tackling
tumor-promoting
TAMs
that
amplify
sensitize
tumors
immunotherapies
safe
effective
manner.
In
this
review,
we
mainly
described
current
potential
nanomaterial-based
therapeutic
strategies
target
TAMs,
restricting
survival,
inhibiting
recruitment
functionally
repolarizing
tumor-supportive
antitumor
type.
understanding
origin
polarization
role
progression
prognostic
significance
was
also
discussed
review.
We
highlighted
evolution
chimeric
antigen
receptor
(CAR)-macrophage
cell
therapy.
Drug Delivery,
Год журнала:
2022,
Номер
29(1), С. 664 - 678
Опубликована: Фев. 25, 2022
Traditional
anticancer
treatments
have
several
limitations,
but
cancer
is
still
one
of
the
deadliest
diseases.
As
a
result,
new
drugs
are
required
for
treatment
cancer.
The
use
metal
nanoparticles
(NPs)
as
alternative
chemotherapeutic
on
rise
in
research.
Metal
NPs
potential
wide
range
applications.
Natural
or
surface-induced
effects
can
be
found
metals.
focus
this
review
therapeutic
metal-based
NPs.
various
types
tumor
targeting
will
discussed
treatment.
Molecules,
Год журнала:
2021,
Номер
26(21), С. 6389 - 6389
Опубликована: Окт. 22, 2021
Gold
nanoparticles
(AuNPs)
have
been
widely
explored
and
are
well-known
for
their
medical
applications.
Chemical
physical
synthesis
methods
a
way
to
make
AuNPs.
In
any
case,
the
hunt
other
more
ecologically
friendly
cost-effective
large-scale
technologies,
such
as
environmentally
biological
processes
known
green
synthesis,
has
gaining
interest
by
worldwide
researchers.
The
international
focus
on
nanotechnology
research
resulted
in
various
nanomaterials
being
used
physiologically
acceptable
Several
advantages
over
conventional
chemical
(simple,
one-step
approach
synthesize,
cost-effectiveness,
energy
efficiency,
biocompatibility)
drawn
scientists’
attention
exploring
of
AuNPs
exploiting
plants’
secondary
metabolites.
Biogenic
approaches,
mainly
plant-based
metal
nanoparticles,
chosen
ideal
strategy
due
environmental
vivo
safety,
well
ease
synthesis.
this
review,
we
reviewed
use
synthesized
treatment
cancer
utilizing
phytochemicals
found
plant
extracts.
This
article
reviews
producing
AuNPs,
characterization
discusses
physiochemical
properties.
study
also
recent
breakthroughs
achievements
using
different
mechanisms
action,
reactive
oxygen
species
(ROS),
mediated
mitochondrial
dysfunction
caspase
activation,
leading
apoptosis,
etc.,
anticancer
cytotoxic
effects.
Understanding
underlying
therapeutic
efficacy
will
aid
developing
personalized
medicines
treatments
potential
strategy.
ACS Applied Nano Materials,
Год журнала:
2021,
Номер
4(2), С. 949 - 972
Опубликована: Фев. 11, 2021
Core–shell
nanoparticles
are
a
unique
class
of
nanostructured
materials,
which
received
significant
attention
in
the
last
two
decades
owing
to
their
exciting
properties
and
wide
variety
applications.
By
judiciously
tuning
"core"
as
well
"shell",
an
assortment
"core–shell"
nanostructures
can
be
obtained
with
tailorable
play
pivotal
roles
designing
materials
for
electromagnetic
interference
(EMI)
shielding
microwave
absorption.
In
recent
times
when
use
high-end
electronics
has
been
on
rise,
pollution
is
inevitable
it
affects
every
walk
life.
Among
numerous
e-pollutions,
recently
highlighted
domain
that
far-reaching
consequences
interference.
EMI
disturbance
created
during
electronic
device's
operation
vicinity
field
caused
by
another
or
electric
device.
Since
decreases
lifetime
degrades
performance
instruments
even
human
health,
crucial
protect
sophisticated
components
from
EM
High-performance
shields
capable
attenuating
propagation
efficiently
have
developed
past
decade.
Herein,
this
review,
we
attempted
provide
logical
guide
various
(≤500
nm)
synthesized
decade
application
absorption
shielding.
The
prime
focus
review
article
highlight
fundamental
concept
reported
systems
literature
along
synthetic
fabrication
strategies
suitable
broadband
absorbers/screeners.
Finally,
also
made
effort
holistic
outlook
perspective
upcoming
research
will
continue
flourish.
Chemical Society Reviews,
Год журнала:
2020,
Номер
49(24), С. 9057 - 9094
Опубликована: Янв. 1, 2020
This
review
provides
a
comprehensive
overview
of
the
recent
advances
in
nanoplatform-based
cascade
engineering
for
cancer
therapy,
by
concentrating
on
design
smart
nanoplatforms
and
implementation
specific
processes.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Ноя. 24, 2023
Abstract
Mesoporous
silica
nanoparticles
(MSNs)
are
recognized
as
a
prime
example
of
nanotechnology
applied
in
the
biomedical
field,
due
to
their
easily
tunable
structure
and
composition,
diverse
surface
functionalization
properties,
excellent
biocompatibility.
Over
past
two
decades,
researchers
have
developed
wide
variety
MSNs-based
nanoplatforms
through
careful
design
controlled
preparation
techniques,
demonstrating
adaptability
various
application
scenarios.
With
continuous
breakthroughs
MSNs
fields
biosensing,
disease
diagnosis
treatment,
tissue
engineering,
etc.,
gradually
moving
from
basic
research
clinical
trials.
In
this
review,
we
provide
detailed
summary
beginning
with
comprehensive
overview
development
history.
We
then
discuss
types
nanostructured
architectures,
well
classification
nanocomposites
according
elements
existed
inorganic
functional
components.
Subsequently,
summarize
primary
purposes
surface-functionalized
modifications
MSNs.
following,
applications
MSNs,
highlight
targeted
therapeutic
modalities
currently
developed.
Given
importance
translation,
also
progress
Finally,
take
perspective
on
future
direction
remaining
challenges
field.
RSC Advances,
Год журнала:
2023,
Номер
13(13), С. 8606 - 8629
Опубликована: Янв. 1, 2023
Cancer
is
known
as
the
most
dangerous
disease
in
world
terms
of
mortality
and
lack
effective
treatment.
Research
on
cancer
treatment
still
active
great
social
importance.
Since
1930,
chemotherapeutics
have
been
used
to
treat
cancer.
However,
such
conventional
treatments
are
associated
with
pain,
side
effects,
a
targeting.
Nanomedicines
an
emerging
alternative
due
their
targeting,
bioavailability,
low
toxicity.
Nanoparticles
target
cells
via
passive
mechanisms.
FDA
approval
for
Doxil®,
several
nano-therapeutics
developed,
few
received
use
Along
liposomes,
solid
lipid
nanoparticles,
polymeric
nanoemulsions,
even
newer
techniques
involving
extracellular
vesicles
(EVs)
thermal
nanomaterials
now
being
researched
implemented
practice.
This
review
highlights
evolution
current
status
therapy,
focus
clinical/pre-clinical
nanomedicine
studies.
Insight
also
provided
into
prospects
this
regard.
