Review on Recent Progress in Magnetic Nanoparticles: Synthesis, Characterization, and Diverse Applications

Frontiers in Chemistry, Journal Year: 2021, Volume and Issue: 9

Published: July 13, 2021

Diverse applications of nanoparticles (NPs) have revolutionized various sectors in society. In the recent decade, particularly magnetic (MNPs) gained enormous interest owing to their specialized areas such as medicine, cancer theranostics, biosensing, catalysis, agriculture, and environment. Controlled surface engineering for design multi-functional MNPs is vital achieving desired application. The demonstrated great efficacy thermoelectric materials, imaging agents, drug delivery vehicles, biosensors. present review, first we briefly discussed main synthetic methods MNPs, followed by characterizations composition. Then potential different with representative examples. At end, gave an overview on current challenges future prospects MNPs. This comprehensive review not only provides mechanistic insight into synthesis, functionalization, application but also outlines limits prospects.

Language: Английский

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Tumor-associated macrophages in cancer: recent advancements in cancer nanoimmunotherapies

Journal of Experimental & Clinical Cancer Research, Journal Year: 2022, Volume and Issue: 41(1)

Published: Feb. 19, 2022

Abstract Cancer immunotherapy has emerged as a novel cancer treatment, although recent trials have produced suboptimal outcomes, with durable responses seen only in small number of patients. The tumor microenvironment (TME) been shown to be responsible for immune escape and therapy failure. vital component the TME is tumor-associated macrophages (TAMs), which are usually associated poor prognosis drug resistance, including immunotherapies, promising targets immunotherapy. Recently, nanoparticles, because their unique physicochemical characteristics, crucial translational moieties tackling tumor-promoting TAMs that amplify sensitize tumors immunotherapies safe effective manner. In this review, we mainly described current potential nanomaterial-based therapeutic strategies target TAMs, restricting survival, inhibiting recruitment functionally repolarizing tumor-supportive antitumor type. understanding origin polarization role progression prognostic significance was also discussed review. We highlighted evolution chimeric antigen receptor (CAR)-macrophage cell therapy.

Language: Английский

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Metal nanoparticles as a promising technology in targeted cancer treatment

Drug Delivery, Journal Year: 2022, Volume and Issue: 29(1), P. 664 - 678

Published: Feb. 25, 2022

Traditional anticancer treatments have several limitations, but cancer is still one of the deadliest diseases. As a result, new drugs are required for treatment cancer. The use metal nanoparticles (NPs) as alternative chemotherapeutic on rise in research. Metal NPs potential wide range applications. Natural or surface-induced effects can be found metals. focus this review therapeutic metal-based NPs. various types tumor targeting will discussed treatment.

Language: Английский

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Green Synthesis of Gold Nanoparticles Using Plant Extracts as Beneficial Prospect for Cancer Theranostics

Molecules, Journal Year: 2021, Volume and Issue: 26(21), P. 6389 - 6389

Published: Oct. 22, 2021

Gold nanoparticles (AuNPs) have been widely explored and are well-known for their medical applications. Chemical physical synthesis methods a way to make AuNPs. In any case, the hunt other more ecologically friendly cost-effective large-scale technologies, such as environmentally biological processes known green synthesis, has gaining interest by worldwide researchers. The international focus on nanotechnology research resulted in various nanomaterials being used physiologically acceptable Several advantages over conventional chemical (simple, one-step approach synthesize, cost-effectiveness, energy efficiency, biocompatibility) drawn scientists’ attention exploring of AuNPs exploiting plants’ secondary metabolites. Biogenic approaches, mainly plant-based metal nanoparticles, chosen ideal strategy due environmental vivo safety, well ease synthesis. this review, we reviewed use synthesized treatment cancer utilizing phytochemicals found plant extracts. This article reviews producing AuNPs, characterization discusses physiochemical properties. study also recent breakthroughs achievements using different mechanisms action, reactive oxygen species (ROS), mediated mitochondrial dysfunction caspase activation, leading apoptosis, etc., anticancer cytotoxic effects. Understanding underlying therapeutic efficacy will aid developing personalized medicines treatments potential strategy.

Language: Английский

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Core–Shell Nanomaterials for Microwave Absorption and Electromagnetic Interference Shielding: A Review

ACS Applied Nano Materials, Journal Year: 2021, Volume and Issue: 4(2), P. 949 - 972

Published: Feb. 11, 2021

Core–shell nanoparticles are a unique class of nanostructured materials, which received significant attention in the last two decades owing to their exciting properties and wide variety applications. By judiciously tuning "core" as well "shell", an assortment "core–shell" nanostructures can be obtained with tailorable play pivotal roles designing materials for electromagnetic interference (EMI) shielding microwave absorption. In recent times when use high-end electronics has been on rise, pollution is inevitable it affects every walk life. Among numerous e-pollutions, recently highlighted domain that far-reaching consequences interference. EMI disturbance created during electronic device's operation vicinity field caused by another or electric device. Since decreases lifetime degrades performance instruments even human health, crucial protect sophisticated components from EM High-performance shields capable attenuating propagation efficiently have developed past decade. Herein, this review, we attempted provide logical guide various (≤500 nm) synthesized decade application absorption shielding. The prime focus review article highlight fundamental concept reported systems literature along synthetic fabrication strategies suitable broadband absorbers/screeners. Finally, also made effort holistic outlook perspective upcoming research will continue flourish.

Language: Английский

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Nanoplatform-based cascade engineering for cancer therapy

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(24), P. 9057 - 9094

Published: Jan. 1, 2020

This review provides a comprehensive overview of the recent advances in nanoplatform-based cascade engineering for cancer therapy, by concentrating on design smart nanoplatforms and implementation specific processes.

Language: Английский

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Magnetic-responsive hydrogels: From strategic design to biomedical applications

Journal of Controlled Release, Journal Year: 2021, Volume and Issue: 335, P. 541 - 556

Published: June 11, 2021

Language: Английский

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Multifunctional mesoporous silica nanoparticles for biomedical applications

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Nov. 24, 2023

Abstract Mesoporous silica nanoparticles (MSNs) are recognized as a prime example of nanotechnology applied in the biomedical field, due to their easily tunable structure and composition, diverse surface functionalization properties, excellent biocompatibility. Over past two decades, researchers have developed wide variety MSNs-based nanoplatforms through careful design controlled preparation techniques, demonstrating adaptability various application scenarios. With continuous breakthroughs MSNs fields biosensing, disease diagnosis treatment, tissue engineering, etc., gradually moving from basic research clinical trials. In this review, we provide detailed summary beginning with comprehensive overview development history. We then discuss types nanostructured architectures, well classification nanocomposites according elements existed inorganic functional components. Subsequently, summarize primary purposes surface-functionalized modifications MSNs. following, applications MSNs, highlight targeted therapeutic modalities currently developed. Given importance translation, also progress Finally, take perspective on future direction remaining challenges field.

Language: Английский

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Cancer nanomedicine: a review of nano-therapeutics and challenges ahead

RSC Advances, Journal Year: 2023, Volume and Issue: 13(13), P. 8606 - 8629

Published: Jan. 1, 2023

Cancer is known as the most dangerous disease in world terms of mortality and lack effective treatment. Research on cancer treatment still active great social importance. Since 1930, chemotherapeutics have been used to treat cancer. However, such conventional treatments are associated with pain, side effects, a targeting. Nanomedicines an emerging alternative due their targeting, bioavailability, low toxicity. Nanoparticles target cells via passive mechanisms. FDA approval for Doxil®, several nano-therapeutics developed, few received use Along liposomes, solid lipid nanoparticles, polymeric nanoemulsions, even newer techniques involving extracellular vesicles (EVs) thermal nanomaterials now being researched implemented practice. This review highlights evolution current status therapy, focus clinical/pre-clinical nanomedicine studies. Insight also provided into prospects this regard.

Language: Английский

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Magnetic torque–driven living microrobots for increased tumor infiltration

Science Robotics, Journal Year: 2022, Volume and Issue: 7(71)

Published: Oct. 26, 2022

Biohybrid bacteria–based microrobots are increasingly recognized as promising externally controllable vehicles for targeted cancer therapy. Magnetic fields in particular have been used a safe means to transfer energy and direct their motion. Thus far, the magnetic control strategies this context rely on poorly scalable field gradients, require active position feedback, or ill-suited diffuse distributions within body. Here, we present torque–driven scheme enhanced transport through biological barriers that complements innate taxis toward tumor cores exhibited by range of bacteria, shown Magnetospirillum magneticum magnetically responsive model organism. This hybrid strategy is readily scalable, independent applicable bacterial dispersed circulatory system. We observed fourfold increase translocation bacteria across vascular endothelium found primary mechanism driving increased torque-driven surface exploration at cell interface. Using spheroids three-dimensional model, fluorescently labeled colonized core regions with up 21-fold higher signal samples exposed rotating fields. In addition transport, demonstrated our offers further advantages, including possibility closed-loop optimization based inductive detection, well spatially selective actuation reduce off-target effects. Last, after systemic intravenous injection mice, showed significantly accumulation, supporting feasibility deploying clinically biohybrid microrobots.

Language: Английский

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