ACS Applied Polymer Materials,
Год журнала:
2021,
Номер
3(7), С. 3504 - 3518
Опубликована: Июнь 21, 2021
Injectable,
self-healable,
and
pH-responsive
hybrid
hydrogels
are
highly
promising
biomaterials
for
controlled
long-term
therapeutic
agent
release
in
cancer
treatment.
Herein,
we
fabricated
an
injectable,
hydrogel
through
the
formation
of
hydrazone
bond
between
hydrazide-functionalized
gelatin
(Gel-ADH)
aldehyde-functionalized
PEG
(diBA-PEG)
polymers.
During
gelation,
resulting
pregels
were
also
integrated
with
laponite
(LAP)
nanodisks
loaded
anticancer
drug,
doxorubicin
(DOX),
yielding
to
Gel-ADH/diBA-PEG/LAP@DOX
hydrogels.
The
gelation
time
was
observed
be
80
s
demonstrated
excellent
injectability
rapid
self-healing
capability.
gel–sol
transition
behaviors
indicated
outstanding
stability,
which
is
a
desirable
feature
drug
delivery
application.
injectable
exhibited
very
efficient
pH-dependent
profile.
Biocompatibility
components
(Gel-ADH,
diBA-PEG,
LAP)
tested
using
human
breast
cell
line
(SVCT)
endothelial
(HUVEC).
All
possess
biocompatibility
even
support
proliferation.
Moreover,
cytotoxicity
investigated
on
(MCF-7)
triple-negative
(MDA-MB-231).
Our
results
clearly
suggested
that
this
offers
potential
as
carrier
Chemical Reviews,
Год журнала:
2021,
Номер
122(5), С. 5068 - 5143
Опубликована: Дек. 28, 2021
Recent
advances
in
nanostructured
materials
and
unconventional
device
designs
have
transformed
the
bioelectronics
from
a
rigid
bulky
form
into
soft
ultrathin
brought
enormous
advantages
to
bioelectronics.
For
example,
mechanical
deformability
of
thus
its
conformal
contact
onto
curved
organs
such
as
brain,
heart,
skin
allowed
researchers
measure
high-quality
biosignals,
deliver
real-time
feedback
treatments,
lower
long-term
side-effects
vivo.
Here,
we
review
various
materials,
fabrication
methods,
strategies
for
flexible
stretchable
electronics,
especially
focusing
on
biointegrated
electronics
using
nanomaterials
their
composites.
First,
summarize
top-down
material
processing
bottom-up
synthesis
methods
nanomaterials.
Next,
discuss
state-of-the-art
technologies
intrinsically
nanocomposites
composed
incorporated
elastomers
or
hydrogels.
We
also
briefly
design
Then
individual
components
bioelectronics,
biosensing,
data
storage,
display,
therapeutic
stimulation,
power
supply
devices,
are
introduced.
Afterward,
representative
application
examples
described.
A
brief
summary
with
discussion
remaining
challenges
concludes
review.
Materials Today Bio,
Год журнала:
2022,
Номер
18, С. 100508 - 100508
Опубликована: Ноя. 30, 2022
Poor
wound
healing
after
diabetes
mellitus
remains
a
challenging
problem,
and
its
pathophysiological
mechanisms
have
not
yet
been
fully
elucidated.
Persistent
bleeding,
disturbed
regulation
of
inflammation,
blocked
cell
proliferation,
susceptible
infection
impaired
tissue
remodeling
are
the
main
features
diabetic
healing.
Conventional
dressings,
including
gauze,
films
bandages,
limited
function.
They
generally
act
as
physical
barriers
absorbers
exudates,
which
fail
to
meet
requirements
whol
process.
Wounds
in
patients
typically
heal
slowly
due
hyperglycemia
within
bed.
Once
bacterial
cells
develop
into
biofilms,
wounds
will
exhibit
robust
drug
resistance.
Recently,
application
stimuli-responsive
hydrogels,
also
known
"smart
hydrogels",
for
has
attracted
particular
attention.
The
basic
feature
this
system
is
capacities
change
mechanical
properties,
swelling
ability,
hydrophilicity,
permeability
biologically
active
molecules,
etc.,
response
various
stimuli,
temperature,
potential
hydrogen
(pH),
protease
other
biological
factors.
Smart
hydrogels
can
improve
therapeutic
efficacy
limit
total
toxicity
according
characteristics
wounds.
In
review,
we
summarized
mechanism
It
hoped
that
work
provide
some
inspiration
suggestions
research
field.
Although
membrane
technology
has
attracted
considerable
attention
for
oily
wastewater
treatment,
the
plastic
waste
generated
from
discarded
membranes
presents
an
immediate
challenge
achieving
eco-friendly
separation.
We
designed
on-demand
biodegradable
superhydrophilic
composed
of
polylactic
acid
nanofibers
in
conjunction
with
polyethylene
oxide
hydrogels
using
electrospinning
ultrafast
purification
water.
Our
results
showed
that
use
increased
number
hydrogen
bonds
formed
between
surface
and
water
molecules
by
357.6%.
This
converted
hydrophobic
into
ones,
which
prevented
fouling
accelerated
emulsion
penetration
through
membranes.
The
oil-in-water
permeance
our
newly
nanofiber
61.9
times
(2.1
×
104
liters
per
square
meter
hour
bar)
separation
efficiency
>99.6%,
was
superior
to
state-of-the-art
Moreover,
formation
found
accelerate
biodegradation
lactic
over
30%,
offering
a
promising
approach
treatment.
Pharmaceutics,
Год журнала:
2023,
Номер
15(7), С. 1829 - 1829
Опубликована: Июнь 26, 2023
Nanofiber
scaffolds
have
emerged
as
a
revolutionary
drug
delivery
platform
for
promoting
wound
healing,
due
to
their
unique
properties,
including
high
surface
area,
interconnected
porosity,
excellent
breathability,
and
moisture
absorption,
well
spatial
structure
which
mimics
the
extracellular
matrix.
However,
use
of
nanofibers
achieve
controlled
loading
release
still
presents
many
challenges,
with
ongoing
research
exploring
how
load
drugs
onto
nanofiber
without
loss
activity
control
in
specific
spatiotemporal
manner.
This
comprehensive
study
systematically
reviews
applications
recent
advances
related
drug-laden
skin-wound
management.
First,
we
introduce
commonly
used
methods
preparation,
electrostatic
spinning,
sol-gel,
molecular
self-assembly,
thermally
induced
phase
separation,
3D-printing
techniques.
Next,
summarize
polymers
preparation
utilizing
scaffolds.
We
then
review
application
drug-loaded
considering
different
stages
healing
acts.
Finally,
briefly
describe
stimulus-responsive
schemes
scaffolds,
other
exciting
systems.
Chemical Society Reviews,
Год журнала:
2022,
Номер
51(10), С. 3926 - 3963
Опубликована: Янв. 1, 2022
The
combination
of
plasmonic
nanomaterials
with
responsive
polymer
hydrogels
yields
novel
materials
and
devices
exceptional
synergetic
properties,
which
are
reviewed
in
the
context
applications,
such
as
sensing
actuation.
