International Journal of Biological Macromolecules, Год журнала: 2022, Номер 210, С. 218 - 232
Опубликована: Май 7, 2022
Язык: Английский
Advances in Colloid and Interface Science, Год журнала: 2024, Номер 332, С. 103267 - 103267
Опубликована: Авг. 3, 2024
Язык: Английский
Процитировано
55
Materials Horizons, Год журнала: 2023, Номер 11(1), С. 37 - 101
Опубликована: Окт. 27, 2023
The unique network characteristics and stimuli responsiveness of supramolecular hydrogels have rendered them highly advantageous in the field wound dressings, showcasing unprecedented potential. However, there are few reports on a comprehensive review hydrogel dressings for repair hemostasis. This first introduces major cross-linking methods hydrogels, which includes hydrogen bonding, electrostatic interactions, hydrophobic host-guest metal ligand coordination some other interactions. Then, we advanced materials reported recent years then summarize basic principles each method. Next, classify structures before outlining their forming process propose potential future directions. Furthermore, also discuss raw materials, structural design principles, material used to achieve functions such as antibacterial function, tissue adhesion, substance delivery, anti-inflammatory antioxidant functions, cell behavior regulation, angiogenesis promotion, hemostasis innovative years. Finally, existing problems well development directions strategy, design, discussed. is proposed stimulate further exploration by researchers future.
Язык: Английский
Процитировано
51
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(11)
Опубликована: Янв. 2, 2024
Oxidative stress is a biochemical process that disrupts the redox balance due to an excess of oxidized substances within cell. closely associated with multitude diseases and health issues, including cancer, diabetes, cardiovascular diseases, neurodegenerative disorders, inflammatory conditions, aging. Therefore, developing antioxidant treatment strategies has emerged as pivotal area medical research. Hydrogels have garnered considerable attention their exceptional biocompatibility, adjustable physicochemical properties, capabilities for drug delivery. Numerous hydrogels been developed proven effective in alleviating oxidative stress. In pursuit more treatments stress-related there urgent need advanced fabrication multifunctional hydrogels. Consequently, authors' focus will be on possess reactive oxygen species nitrogen scavenging capabilities, role therapy evaluated. Herein, mechanisms design applications are discussed systematically order provide critical insights further advancements field.
Язык: Английский
Процитировано
50
Carbohydrate Polymers, Год журнала: 2024, Номер 333, С. 121952 - 121952
Опубликована: Фев. 19, 2024
Язык: Английский
Процитировано
39
Carbohydrate Polymers, Год журнала: 2024, Номер 331, С. 121873 - 121873
Опубликована: Янв. 30, 2024
Язык: Английский
Процитировано
37
Journal of Controlled Release, Год журнала: 2024, Номер 369, С. 420 - 443
Опубликована: Апрель 5, 2024
Язык: Английский
Процитировано
32
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(18)
Опубликована: Март 23, 2024
Intense and persistent oxidative stress, excessive inflammation, impaired angiogenesis severely hinder diabetic wound healing. Bioactive hydrogel dressings with immunoregulatory proangiogenic properties have great promise in treating wounds. However, the therapeutic effects of always depend on drugs side effects, expensive cytokines, cell therapies. Herein, a novel dynamic borate-bonds crosslinked hybrid multifunctional photothermal are developed to regulate microenvironment sites accelerate whole process its healing without additional medication. The is composed phenylboronic acid-modified chitosan hyaluronic acid (HA) by tannic (TA) through borate bonds Prussian blue nanoparticles (PBNPs) response characteristics embedded polymer networks. results indicate hydrogels show inherent broad-spectrum antioxidative activities integrated interaction bonds, TA, PBNPs. Meanwhile, combined regulation macrophage phenotype HA, inflammatory wounds transformed. Moreover, then enhanced mild effect PBNPs, followed promoted epithelialization collagen deposition. In summary, this system accelerates all stages repair immunomodulation, proangiogenesis, showing potential applications management.
Язык: Английский
Процитировано
26
Carbohydrate Polymers, Год журнала: 2024, Номер 334, С. 122014 - 122014
Опубликована: Март 4, 2024
Язык: Английский
Процитировано
25
Materials, Год журнала: 2024, Номер 17(2), С. 278 - 278
Опубликована: Янв. 5, 2024
Effective wound treatment has become one of the most important challenges for healthcare as it continues to be leading causes death worldwide. Therefore, care technologies significantly evolved in order provide a holistic approach based on various designs functional dressings. Among them, hydrogels have been widely used due their biocompatibility and similarity extracellular matrix. The hydrogel formula offers control an optimal moisture level its ability absorb excess fluid from or release needed. Additionally, can successfully integrated with plethora biologically active components (e.g., nanoparticles, pharmaceuticals, natural extracts, peptides), thus enhancing performance resulting composite healing applications. In this review, the-state-of-the-art discoveries related stimuli-responsive hydrogel-based dressings summarized, taking into account antimicrobial, anti-inflammatory, antioxidant, hemostatic properties, well other effects re-epithelialization, vascularization, restoration tissue) use.
Язык: Английский
Процитировано
22
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Май 11, 2024
Abstract The continuously growing utilization of wound healing materials and skin bioelectronics urges the development flexible hydrogels for personal therapy health management. Versatile conductive prepared from natural biomass are ideal candidates as one promising solutions chronic Here, study proposes a kind robust (strain: 1560.8%), adhesive, self‐healing, injectable, antibacterial (sterilization rate: 99%), near‐infrared (NIR) photothermal responsive, biocompatible, hydrogel (CPPFe@TA) composed carboxymethyl cellulose tannic acid/iron ion complex (TA@Fe 3+ ), featuring rapid self‐assembly tunable crosslinking time. TA@Fe facilitated self‐catalysis polymerization reaction, time could be controlled by adjusting Fe concentration. Under NIR irradiation, exhibited remarkable performance. In full‐thickness defect repair experiment on mice, dressing significantly enhanced healing. After 14 days, rate (95.49%) CPPFe@TA3 + treatment greatly exceeded that commercial dressings. Meanwhile, has good electrical conductivity thermo‐responsiveness, making them in physiological signal monitoring rehabilitation exercise This work therefore offers strategy developing versatile biomass‐based hydrogels, which is expected to applicable integrated regenerative bioelectronics.
Язык: Английский
Процитировано
22