Brazilian Journal of Biology,
Год журнала:
2024,
Номер
84
Опубликована: Янв. 1, 2024
Peripheral
nerve
injuries
are
major
causes
of
disability
worldwide.
The
current
standard
treatment,
autologous
grafting,
puts
the
donor
region
at
risk
and
has
limited
availability.
A
systematic
search
MEDLINE,
EMBASE,
Web
Science
databases
for
studies
published
between
January
1,
2008,
September
04,
2024,
was
performed
to
compare
interventions
using
chitosan
tubes
with
non-intervention
or
grafts
in
rats
artificially
injured
sciatic
nerves.
Twenty-one
experimental
including
738
animals
were
selected.
Nerve
repair
conduits
resulted
a
higher
functional
index
compared
non-intervention.
Higher
conduction
velocity
greater
number
myelinated
fibers
observed
treated
no
intervention
primary
groups.
However,
compound
muscle
action
potentials
somatosensory
evoked
superior
latter
nerves
polymer.
Frontiers in Neurology,
Год журнала:
2024,
Номер
15
Опубликована: Март 26, 2024
Peripheral
nerve
injuries,
caused
by
various
reasons,
often
lead
to
severe
sensory,
motor,
and
autonomic
dysfunction
or
permanent
disability,
posing
a
challenging
problem
in
regenerative
medicine.
Autologous
transplantation
has
been
the
gold
standard
traditional
treatments
but
faces
numerous
limitations
risk
factors,
such
as
donor
area
denervation,
increased
surgical
complications,
diameter
bundle
mismatches.
The
extracellular
matrix
(ECM)
is
complex
molecular
network
synthesized
released
into
space
cells
residing
tissues
organs.
Its
main
components
include
collagen,
proteoglycans/glycosaminoglycans,
elastin,
laminin,
fibronectin,
etc.,
providing
structural
biochemical
support
surrounding
cells,
crucial
for
cell
survival
growth.
Schwann
primary
glial
peripheral
nervous
system,
play
important
roles.
considered
therapy
making
ECM
derived
from
one
of
most
suitable
biomaterials
repair.
To
better
understand
mechanisms
regeneration
their
optimal
application,
this
review
provides
an
overview
roles
regeneration.
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101503 - 101503
Опубликована: Фев. 6, 2025
Peripheral
nerve
injuries
are
a
prevalent
global
issue
that
has
garnered
great
concern.
Although
autografts
remain
the
preferred
clinical
approach
to
repair,
their
efficacy
is
hampered
by
factors
like
donor
scarcity.
The
emergence
of
guidance
conduits
as
novel
tissue
engineering
tools
offers
promising
alternative
strategy.
This
review
aims
interpret
and
commercialization
from
both
laboratory
perspectives.
To
enhance
comprehension
situations,
this
article
provides
comprehensive
analysis
approved
United
States
Food
Drug
Administration.
It
proposes
initial
six
months
post-transplantation
critical
window
period
for
evaluating
efficacy.
Additionally,
study
conducts
systematic
discussion
on
research
progress
conduits,
focusing
biomaterials
add-on
strategies
pivotal
regeneration,
supported
literature
analysis.
conduit
materials
prospective
optimal
thoroughly
discussed.
strategies,
together
with
distinct
obstacles
potentials
deeply
analyzed.
Based
above
evaluations,
development
path
manufacturing
strategy
envisioned.
conclusion
promoting
summarized
follows:
1)
optimization
fundamental
means;
2)
phased
application
additional
emphasized
direction;
3)
additive
techniques
necessary
tools.
As
result,
findings
provide
academic
practitioners
valuable
insights
may
facilitate
future
endeavors
conduits.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(17)
Опубликована: Март 5, 2023
Peripheral
nerve
defects
are
a
worldwide
problem,
and
autologous
transplantation
is
currently
the
gold-standard
treatment
for
them.
Tissue-engineered
(TEN)
grafts
widely
considered
promising
methods
same,
have
attracted
much
attention.
To
improve
repair,
incorporation
of
bionics
into
TEN
has
become
focus
research.
In
this
study,
novel
bionic
graft
with
biomimetic
structure
composition
designed.
For
purpose,
chitin
helical
scaffold
fabricated
by
means
mold
casting
acetylation
using
chitosan
as
raw
material,
following
which
fibrous
membrane
electrospun
on
outer
layer
scaffold.
The
lumen
filled
human
bone
mesenchymal
stem
cell-derived
extracellular
matrix
fibers
to
provide
nutrition
topographic
guidance,
respectively.
prepared
then
transplanted
bridge
10
mm
sciatic
in
rats.
Morphological
functional
examination
shows
that
repair
effects
autografts
similar.
described
study
great
potential
application
offers
new
way
clinical
peripheral
defects.
Stem Cell Research & Therapy,
Год журнала:
2024,
Номер
15(1)
Опубликована: Июнь 1, 2024
Abstract
Background
Nerve
guide
conduits
are
a
promising
strategy
for
reconstructing
peripheral
nerve
defects.
Improving
the
survival
rate
of
seed
cells
in
is
still
challenge
and
microcarriers
an
excellent
three-dimensional
(3D)
culture
scaffold.
Here,
we
investigate
effect
3D
on
biological
characteristics
adipose
mesenchymal
stem
(ADSCs)
to
evaluate
efficacy
chitosan
filled
with
loaded
ADSCs
repairing
Methods
In
vitro,
prepared
porous
microspheres
by
modified
emulsion
cross-linking
method
loading
evaluated
growth
status
function
ADSCs.
vivo,
ADSCs-loaded
were
injected
into
repair
12
mm
sciatic
defect
rats.
Results
Compared
conventional
two-dimensional
(2D)
culture,
more
conducive
proliferation,
migration,
secretion
trophic
factors
addition,
gait
analysis,
neuro-electrophysiology,
histological
evaluation
nerves
muscles
showed
that
ADSC
microcarrier-loaded
effective
improving
regeneration.
Conclusions
The
microcarrier
this
study
has
high
cell
engraftment
good
potential
repair.
Graphical
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(16), С. 12956 - 12956
Опубликована: Авг. 19, 2023
Peripheral
nerve
injuries
are
common
neurological
disorders,
and
the
available
treatment
options,
such
as
conservative
management
surgical
repair,
often
yield
limited
results.
However,
there
is
growing
interest
in
potential
of
using
chitosan-based
biopolymers
a
novel
therapeutic
approach
to
treating
these
injuries.
Chitosan-based
possess
unique
characteristics,
including
biocompatibility,
biodegradability,
ability
stimulate
cell
proliferation,
making
them
highly
suitable
for
repairing
defects
promoting
regeneration
functional
recovery.
Furthermore,
can
be
utilized
drug
delivery
systems
control
release
agents
facilitate
growth
cells.
This
comprehensive
review
focuses
on
latest
advancements
utilizing
peripheral
regeneration.
By
harnessing
biopolymers,
we
pave
way
innovative
strategies
that
significantly
improve
outcomes
injury
offering
renewed
hope
better
prospects
patients
need.
