Chitosan conduits for peripheral nerve repair: a systematic review of animal studies DOI Creative Commons
Thales Pardini Fagundes, G. A. Caetano, Vinícius Toledo Ribas

et al.

Brazilian Journal of Biology, Journal Year: 2024, Volume and Issue: 84

Published: Jan. 1, 2024

Peripheral nerve injuries are major causes of disability worldwide. The current standard treatment, autologous grafting, puts the donor region at risk and has limited availability. A systematic search MEDLINE, EMBASE, Web Science databases for studies published between January 1, 2008, September 04, 2024, was performed to compare interventions using chitosan tubes with non-intervention or grafts in rats artificially injured sciatic nerves. Twenty-one experimental including 738 animals were selected. Nerve repair conduits resulted a higher functional index compared non-intervention. Higher conduction velocity greater number myelinated fibers observed treated no intervention primary groups. However, compound muscle action potentials somatosensory evoked superior latter nerves polymer.

Language: Английский

Electrospinning and electrospun polysaccharide-based nanofiber membranes: A review DOI

Weiyin Su,

Zeyu Chang,

E Yuyu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 263, P. 130335 - 130335

Published: Feb. 23, 2024

Language: Английский

Citations

50
Sea Cucumber-Inspired Microneedle Nerve Guidance Conduit for Synergistically Inhibiting Muscle Atrophy and Promoting Nerve Regeneration DOI

Cewen Hu,

Bin Liu,

Xinyue Huang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(22), P. 14427 - 14440

Published: May 22, 2024

Muscle atrophy resulting from peripheral nerve injury (PNI) poses a threat to patient's mobility and sensitivity. However, an effective method inhibit muscle following PNI remains elusive. Drawing inspiration the sea cucumber, we have integrated microneedles (MNs) microchannel technology into guidance conduits (NGCs) develop bionic microneedle NGCs (MNGCs) that emulate structure piezoelectric function of cucumbers. Morphologically, MNGCs feature outer surface with outward-pointing needle tips capable applying electrical stimulation denervated muscles. Simultaneously, interior contains microchannels designed guide migration Schwann cells (SCs). Physiologically, incorporation conductive reduced graphene oxide zinc nanoparticles polycaprolactone scaffold enhances conductivity properties, facilitating SCs' migration, myelin regeneration, axon growth, restoration neuromuscular function. These combined effects ultimately lead inhibition Consequently, concept synergistic effect inhibiting promoting regeneration has capacity transform traditional approach repair find broad applications in repair.

Language: Английский

Citations

23
Interactions between Schwann cell and extracellular matrix in peripheral nerve regeneration DOI Creative Commons

Maorong Jiang,

Muyang Chen,

Nana Liu

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: March 26, 2024

Peripheral nerve injuries, caused by various reasons, often lead to severe sensory, motor, and autonomic dysfunction or permanent disability, posing a challenging problem in regenerative medicine. Autologous transplantation has been the gold standard traditional treatments but faces numerous limitations risk factors, such as donor area denervation, increased surgical complications, diameter bundle mismatches. The extracellular matrix (ECM) is complex molecular network synthesized released into space cells residing tissues organs. Its main components include collagen, proteoglycans/glycosaminoglycans, elastin, laminin, fibronectin, etc., providing structural biochemical support surrounding cells, crucial for cell survival growth. Schwann primary glial peripheral nervous system, play important roles. considered therapy making ECM derived from one of most suitable biomaterials repair. To better understand mechanisms regeneration their optimal application, this review provides an overview roles regeneration.

Language: Английский

Citations

9
Potentially commercializable nerve guidance conduits for peripheral nerve injury: Past, present, and future DOI Creative Commons

Chundi Liu,

Mouyuan Sun,

Lining Lin

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101503 - 101503

Published: Feb. 6, 2025

Peripheral nerve injuries are a prevalent global issue that has garnered great concern. Although autografts remain the preferred clinical approach to repair, their efficacy is hampered by factors like donor scarcity. The emergence of guidance conduits as novel tissue engineering tools offers promising alternative strategy. This review aims interpret and commercialization from both laboratory perspectives. To enhance comprehension situations, this article provides comprehensive analysis approved United States Food Drug Administration. It proposes initial six months post-transplantation critical window period for evaluating efficacy. Additionally, study conducts systematic discussion on research progress conduits, focusing biomaterials add-on strategies pivotal regeneration, supported literature analysis. conduit materials prospective optimal thoroughly discussed. strategies, together with distinct obstacles potentials deeply analyzed. Based above evaluations, development path manufacturing strategy envisioned. conclusion promoting summarized follows: 1) optimization fundamental means; 2) phased application additional emphasized direction; 3) additive techniques necessary tools. As result, findings provide academic practitioners valuable insights may facilitate future endeavors conduits.

Language: Английский

Citations

1
Percutaneous electrical stimulation combined with conductive nerve guidance conduits for peripheral nerve regeneration DOI Creative Commons

Tong Qi,

Xiao Wang, Maling Gou

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162124 - 162124

Published: March 1, 2025

Language: Английский

Citations

1
Experimental Study on Repairing Peripheral Nerve Defects with Novel Bionic Tissue Engineering DOI Creative Commons
Tong Qi, Xu Zhang, Xiaosong Gu

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(17)

Published: March 5, 2023

Peripheral nerve defects are a worldwide problem, and autologous transplantation is currently the gold-standard treatment for them. Tissue-engineered (TEN) grafts widely considered promising methods same, have attracted much attention. To improve repair, incorporation of bionics into TEN has become focus research. In this study, novel bionic graft with biomimetic structure composition designed. For purpose, chitin helical scaffold fabricated by means mold casting acetylation using chitosan as raw material, following which fibrous membrane electrospun on outer layer scaffold. The lumen filled human bone mesenchymal stem cell-derived extracellular matrix fibers to provide nutrition topographic guidance, respectively. prepared then transplanted bridge 10 mm sciatic in rats. Morphological functional examination shows that repair effects autografts similar. described study great potential application offers new way clinical peripheral defects.

Language: Английский

Citations

18
Harnessing three-dimensional porous chitosan microsphere embedded with adipose-derived stem cells to promote nerve regeneration DOI Creative Commons
Yaqiong Zhu, Dan Yi, Jing Wang

et al.

Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)

Published: June 1, 2024

Abstract Background Nerve guide conduits are a promising strategy for reconstructing peripheral nerve defects. Improving the survival rate of seed cells in is still challenge and microcarriers an excellent three-dimensional (3D) culture scaffold. Here, we investigate effect 3D on biological characteristics adipose mesenchymal stem (ADSCs) to evaluate efficacy chitosan filled with loaded ADSCs repairing Methods In vitro, prepared porous microspheres by modified emulsion cross-linking method loading evaluated growth status function ADSCs. vivo, ADSCs-loaded were injected into repair 12 mm sciatic defect rats. Results Compared conventional two-dimensional (2D) culture, more conducive proliferation, migration, secretion trophic factors addition, gait analysis, neuro-electrophysiology, histological evaluation nerves muscles showed that ADSC microcarrier-loaded effective improving regeneration. Conclusions The microcarrier this study has high cell engraftment good potential repair. Graphical

Language: Английский

Citations

7
Prospects of Using Chitosan-Based Biopolymers in the Treatment of Peripheral Nerve Injuries DOI Open Access
Meng Zhang, Heng An, Fengshi Zhang

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(16), P. 12956 - 12956

Published: Aug. 19, 2023

Peripheral nerve injuries are common neurological disorders, and the available treatment options, such as conservative management surgical repair, often yield limited results. However, there is growing interest in potential of using chitosan-based biopolymers a novel therapeutic approach to treating these injuries. Chitosan-based possess unique characteristics, including biocompatibility, biodegradability, ability stimulate cell proliferation, making them highly suitable for repairing defects promoting regeneration functional recovery. Furthermore, can be utilized drug delivery systems control release agents facilitate growth cells. This comprehensive review focuses on latest advancements utilizing peripheral regeneration. By harnessing biopolymers, we pave way innovative strategies that significantly improve outcomes injury offering renewed hope better prospects patients need.

Language: Английский

Citations

14
Chitosan nerve conduit filled with ZIF-8-functionalized guide microfibres enhances nerve regeneration and sensory function recovery in sciatic nerve defects DOI
Xu Zhang, Tong Qi, Yu Sun

et al.

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 480, P. 147933 - 147933

Published: Dec. 13, 2023

Language: Английский

Citations

11
Bionic tissue engineering of peripheral nerves and progress in neuroregeneration DOI
Dian Jiao, Yumin Yang, Hongkui Wang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162123 - 162123

Published: March 1, 2025

Language: Английский

Citations

0