Quaternary ammonium grafted chitosan hydrogel with enhanced antibacterial performance as tannin acid and deferoxamine carrier to promote diabetic wound healing DOI

Weichen Sun,

Xiaoting Zuo,

Liang Yu

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 244, P. 114160 - 114160

Published: Aug. 11, 2024

Language: Английский

Intelligent biobased hydrogels for diabetic wound healing: A review DOI
Hanzhang Wang, Liming Zhang

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 484, P. 149493 - 149493

Published: Feb. 10, 2024

Language: Английский

Citations

68
Hybrid Hydrogels for Immunoregulation and Proangiogenesis through Mild Heat Stimulation to Accelerate Whole‐Process Diabetic Wound Healing DOI

Qianru Guo,

Tianyu Yin,

Wei‐Chien Huang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(18)

Published: March 23, 2024

Intense and persistent oxidative stress, excessive inflammation, impaired angiogenesis severely hinder diabetic wound healing. Bioactive hydrogel dressings with immunoregulatory proangiogenic properties have great promise in treating wounds. However, the therapeutic effects of always depend on drugs side effects, expensive cytokines, cell therapies. Herein, a novel dynamic borate-bonds crosslinked hybrid multifunctional photothermal are developed to regulate microenvironment sites accelerate whole process its healing without additional medication. The is composed phenylboronic acid-modified chitosan hyaluronic acid (HA) by tannic (TA) through borate bonds Prussian blue nanoparticles (PBNPs) response characteristics embedded polymer networks. results indicate hydrogels show inherent broad-spectrum antioxidative activities integrated interaction bonds, TA, PBNPs. Meanwhile, combined regulation macrophage phenotype HA, inflammatory wounds transformed. Moreover, then enhanced mild effect PBNPs, followed promoted epithelialization collagen deposition. In summary, this system accelerates all stages repair immunomodulation, proangiogenesis, showing potential applications management.

Language: Английский

Citations

34
Bioinspired soft-hard combined system with mild photothermal therapeutic activity promotes diabetic bone defect healing via synergetic effects of immune activation and angiogenesis DOI Creative Commons
Minhao Wu, Huifan Liu, Yufan Zhu

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 14(10), P. 4014 - 4057

Published: Jan. 1, 2024

Background:The comprehensive management of diabetic bone defects remains a substantial clinical challenge due to the hostile regenerative microenvironment characterized by aggravated inflammation, excessive reactive oxygen species (ROS), bacterial infection, impaired angiogenesis, and unbalanced homeostasis.Thus, an advanced multifunctional therapeutic platform capable simultaneously achieving immune regulation, elimination, tissue regeneration is urgently designed for augmented under pathological milieu.Methods Results: Herein, photoactivated soft-hard combined scaffold system (PGCZ) was engineered introducing polydopamine-modified zeolitic imidazolate framework-8-loaded double-network hydrogel (soft matrix component) into 3D-printed poly(ε-caprolactone) (PCL) (hard component).The versatile PGCZ based on PCL thus prepared features highly extracellular matrix-mimicking microstructure, suitable biodegradability mechanical properties, excellent photothermal performance, allowing long-term structural stability support regeneration.Under periodic near-infrared (NIR) irradiation, localized effect triggers on-demand release Zn 2+ , which, together with repeated mild hyperthermia, collectively accelerates proliferation osteogenic differentiation preosteoblasts potently inhibits growth biofilm formation.Additionally, also presents outstanding immunomodulatory ROS scavenging capacities, which regulate M2 polarization macrophages drive functional cytokine secretion, leading pro-regenerative in situ enhanced vascularization.In vivo experiments further demonstrated that conjunction activity remarkably attenuated local inflammatory cascade, initiated endogenous stem cell recruitment neovascularization, orchestrated osteoblast/osteoclast balance, ultimately accelerating regeneration. Ivyspring

Language: Английский

Citations

33
Multi-Functional hydrogels to promote diabetic wound Healing: A review DOI

Yongyan Yang,

Shuangling Zhong,

Fanyu Meng

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154855 - 154855

Published: Aug. 14, 2024

Language: Английский

Citations

32
Bioinspired wet adhesive carboxymethyl cellulose-based hydrogel with rapid shape adaptability and antioxidant activity for diabetic wound repair DOI

Hongxia Xie,

Ge Shi, Ruizi Wang

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 334, P. 122014 - 122014

Published: March 4, 2024

Language: Английский

Citations

28
Multifunctional polypeptide-based hydrogel bio-adhesives with pro-healing activities and their working principles DOI
Jiahao Yang, Zhengyue Wang,

Xiaoben Liang

et al.

Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 327, P. 103155 - 103155

Published: April 16, 2024

Language: Английский

Citations

26
Kill Two Birds with One Stone: Dual‐Metal MOF‐Nanozyme‐Decorated Hydrogels with ROS‐Scavenging, Oxygen‐Generating, and Antibacterial Abilities for Accelerating Infected Diabetic Wound Healing DOI
Yun‐Jie Wei, Heng Chen,

Ziwen Zhou

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 6, 2024

Abstract Diabetic wounds tend to develop into nonhealing associated with the complex inflammatory microenvironment of uncontrollable bacterial infection, reactive oxygen species (ROS) accumulation, and chronic hypoxia. Damaged blood vessels hinder metabolic circulation, aggravating hypoxia, ROS accumulation further exacerbating diabetic wound microenvironment. However, existing treatments a single functionality have difficulty healing complicated wounds. Therefore, developing an integrative strategy improve hostility is urgently needed. Herein, multifunctional genipin (GP)‐crosslinked chitosan (CS)‐based hydrogels decorated biomimetic metal–organic framework (MOF)‐nanozymes natural antibacterial agent chlorogenic acid (CGA), which named MOF/CGA@GP‐CS (MCGC), are prepared. With catalase (CAT)‐like activity, these dual‐metal MOF‐nanozymes promising bioreactors for simultaneously alleviating hypoxia by converting elevated endogenous H 2 O dissolved in In addition, other component polyphenolic CGA acts as mild agent, efficiently inhibiting infection avoiding antibiotic resistance. Impressively, MCGC accelerate infected eliminating oxidative stress, increasing oxygenation, reversing vivo. this work, effective based on hydrogel dressings successfully developed applied management.

Language: Английский

Citations

26
Ultra-fast cryogenic self-healing ionic hydrogel for flexible wearable bioelectronics DOI

Lianghao Jia,

Jinrui Jiang,

Aobo Ren

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 495, P. 153734 - 153734

Published: July 3, 2024

Language: Английский

Citations

24
On-Site Electrospinning Nanofiber Membranes Incorporating V-Shaped Organic Semiconductors for Multifunctional Diabetic Wound Dressing DOI

Ling Hong,

Pu Qiu,

Shining Niu

et al.

Advanced Fiber Materials, Journal Year: 2024, Volume and Issue: 6(5), P. 1413 - 1427

Published: May 7, 2024

Language: Английский

Citations

20
Cerium dioxide nanozyme doped hybrid hydrogel with antioxidant and antibacterial abilities for promoting diabetic wound healing DOI

Shuhan Zhao,

Junhong Ling, Nan Wang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154517 - 154517

Published: Aug. 3, 2024

Language: Английский

Citations

19