Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Дек. 30, 2024
Abstract
The
imbalance
in
the
proportion
of
M1/M2
macrophage
polarization
is
a
crucial
contributor
to
persistent
progression
osteoarthritis
(OA).
This
study
aimed
evaluate
effects
low-dose
biocompatible
ionized
air
(BIA)
on
and
its
subsequent
chondroprotective
effects,
thereby
validating
potential
BIA
slowing
OA.
In
vitro
experiments
demonstrated
that
modulates
M1
macrophages
toward
M2
phenotype
via
ROS-mediated
STAT6
pathway.
shift
reduces
expression
pro-inflammatory
mediators
while
increasing
anti-inflammatory
pro-chondrogenic
factors,
leading
an
improved
microenvironment
surrounding
chondrocytes.
direct
benefits
this
include
enhanced
chondrocyte
viability,
inhibition
apoptosis,
reduced
degradation
extracellular
matrix.
vivo
studies
rats
showed
inhibited
infiltration
synovium,
upregulated
macrophages,
alleviated
cartilage
degeneration,
delayed
OA
progression.
gas-based
regulatory
strategy
may
open
new
avenues
for
treatment
Polymers,
Год журнала:
2024,
Номер
16(19), С. 2755 - 2755
Опубликована: Сен. 29, 2024
Polyvinyl
alcohol
(PVA)-based
hydrogels
have
attracted
significant
attention
due
to
their
excellent
biocompatibility,
tunable
mechanical
properties,
and
ability
form
stable
three-dimensional
networks.
This
comprehensive
review
explores
the
recent
advancements
in
PVA-based
hydrogels,
focusing
on
unique
fabrication
strategies,
multifunctional
applications.
Firstly,
it
discusses
various
facile
synthesis
techniques,
including
freeze/thaw
cycles,
chemical
cross-linking,
enhancement
which
led
enhanced
strength,
elasticity,
responsiveness
external
stimuli.
These
improvements
expanded
applicability
of
critical
areas
such
as
biomedical,
environmental
treatment,
flexible
electronics,
civil
engineering,
well
other
emerging
Additionally,
integration
smart
functionalities,
self-healing
capabilities
multi-responsiveness,
is
also
examined.
Despite
progress,
challenges
remain,
optimizing
stability
under
varying
conditions
addressing
potential
toxicity
cross-linkers.
The
concludes
by
outlining
future
perspectives,
emphasizing
fields
like
regenerative
medicine,
sustainability,
advanced
manufacturing.
It
underscores
importance
interdisciplinary
collaboration
realizing
full
these
versatile
materials
address
pressing
societal
challenges.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(17)
Опубликована: Фев. 7, 2024
Abstract
Osteoarthritis
is
a
degenerative
joint
disease
characterized
by
cartilage
deterioration
and
subsequent
inflammatory
changes
in
the
underlying
bone.
Injectable
hydrogels
have
emerged
as
promising
approach
for
controlled
drug
delivery
therapies.
This
review
focuses
on
latest
developments
utilizing
injectable
vehicles
targeted
to
promote
repair
regeneration.
The
pathogenesis
of
osteoarthritis
discussed
provide
comprehensive
understanding
progression.
Subsequently,
various
types
used
intra‐articular
are
discussed.
Specifically,
physically
chemically
crosslinked
critically
analyzed,
with
an
emphasis
their
fabrication
strategies
capacity
encapsulate
release
therapeutic
agents
manner.
Furthermore,
potential
incorporating
growth
factors,
anti‐inflammatory
drugs,
cells
within
these
Overall,
this
offers
guide
navigating
landscape
hydrogel‐based
therapeutics
osteoarthritis.
Polymers,
Год журнала:
2024,
Номер
16(14), С. 2021 - 2021
Опубликована: Июль 15, 2024
Poly(vinyl
alcohol)
(PVA)
is
a
versatile
synthetic
polymer,
used
for
the
design
of
hydrogels,
porous
membranes
and
films.
Its
solubility
in
water,
film-
hydrogel-forming
capabilities,
non-toxicity,
crystallinity
excellent
mechanical
properties,
chemical
inertness
stability
towards
biological
fluids,
superior
oxygen
gas
barrier
good
printability
availability
(relatively
low
production
cost)
are
main
aspects
that
make
PVA
suitable
variety
applications,
from
biomedical
pharmaceutical
uses
to
sensing
devices,
packaging
materials
or
wastewater
treatment.
However,
pure
present
limited
flexibility
poor
biocompatibility
biodegradability,
which
restrict
its
use
alone
various
applications.
mixed
with
other
polymers
biomolecules
(polysaccharides,
proteins,
peptides,
amino
acids
etc.),
as
well
inorganic/organic
compounds,
generates
wide
PVA’s
shortcomings
considerably
improved,
new
functionalities
obtained.
Also,
transformation
brings
features
opens
door
unexpected
uses.
The
review
focused
on
recent
advances
PVA-based
hydrogels.
Biomedicines,
Год журнала:
2024,
Номер
12(4), С. 923 - 923
Опубликована: Апрель 22, 2024
This
review
critically
evaluates
advancements
in
multifunctional
hydrogels,
particularly
focusing
on
their
applications
osteoarthritis
(OA)
therapy.
As
research
evolves
from
traditional
natural
materials,
there
is
a
significant
shift
towards
synthetic
and
composite
known
for
superior
mechanical
properties
enhanced
biodegradability.
spotlights
novel
such
as
injectable
microneedle
technology,
responsive
which
have
revolutionized
OA
treatment
through
targeted
efficient
therapeutic
delivery.
Moreover,
it
discusses
innovative
hydrogel
including
protein-based
superlubricating
potential
to
reduce
joint
friction
inflammation.
The
integration
of
bioactive
compounds
within
hydrogels
augment
efficacy
also
examined.
Furthermore,
the
anticipates
continued
technological
deeper
understanding
hydrogel-based
therapies.
It
emphasizes
provide
tailored,
minimally
invasive
treatments,
thus
highlighting
critical
role
advancing
dynamic
field
biomaterial
science
management.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(25), С. 6242 - 6256
Опубликована: Янв. 1, 2024
An
artificial
nano-enzyme-enhanced
hydrogel
was
developed
to
treat
OA
through
a
ternary
synergistic
strategy
of
efficiently
driving
O
2
production
from
endogenous
ROS
in
chondrocytes
and
maintaining
lubrication
at
the
articular
cartilage
interface.
Journal of Biomaterials Science Polymer Edition,
Год журнала:
2025,
Номер
unknown, С. 1 - 39
Опубликована: Янв. 24, 2025
Bone
disorders
have
increased
with
increasing
the
human
lifespan,
and
despite
tissue's
ability
to
self-regeneration,
in
many
congenital
problems
hard
fractures,
bone
grafting
such
as
autograft,
allograft,
biomaterials
implantation
through
surgery
is
traditionally
used.
Because
of
adverse
effects
these
methods,
emergence
injectable
hydrogels
without
need
for
causing
more
pain
patient
stunning
develop
a
new
pattern
tissue
engineering.
These
materials
are
formed
various
natural
synthetic
polymers
crosslinked
network
chemical
methods
click
chemistry,
Michael
enhancement,
Schiff's
base
enzymatic
reaction
physical
interactions
high
water
absorption
which
can
mimic
environment
cells.
The
purpose
this
research
review
capabilities
class
regeneration
last
decade
adaptable
properties,
fill
defect
sites
an
irregular
shape,
grow
hormones
or
release
drugs,
response
external
stimuli.
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 1133 - 1145
Опубликована: Янв. 1, 2025
Osteoarthritis
(OA),
a
prevalent
joint
disease,
causes
immense
suffering
to
thousands
of
patients,
impairing
their
mobility
and
diminishing
quality
life.
Current
treatment
methods
primarily
rely
on
analgesics
or
anti-inflammatory
drugs
alleviate
symptoms
but
fail
achieve
the
desired
therapeutic
outcome.
To
better
realize
effects
OA,
procyanidins
(PAs),
as
type
plant
flavonoids
with
strong
antioxidant
activities,
were
designed
self-assembly
well-dispersible
Pluronic
F127
(PF127)
through
hydrogen-bond
interaction
present
an
injectable,
biocompatibility
PA
nanospheres.
These
nanospheres
significantly
increased
cell
viability
in
mouse
L929
fibroblasts
ADTC5
chondrocytes
compared
unassembled
PAs.
In
addition,
self-assembling
PAs/PF127
enhanced
protein
expression
collagen
(COL1A1
COL3A1)
fibroblasts,
glycosaminoglycan
COL2A1
was
also
higher
than
PAs
chondrocytes,
this
heralded
potential
OA
repair
strategies
at
cellular
level.
enzymolysis
model
rat
reduce
space
swelling
early
stages
cartilage
destruction
accelerate
formation
subchondral
bone
cartilaginous
surface.
This
study
offers
valuable
insights
into
preparation
novel
for
effective
OA.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
13
Опубликована: Фев. 17, 2025
Osteoarthritis
is
one
of
the
most
common
degenerative
joint
diseases,
which
seriously
affects
life
middle-aged
and
elderly
people.
Traditional
treatments
such
as
surgical
treatment
systemic
medication,
often
do
not
achieve
expected
or
optimal
results,
leads
to
severe
trauma
a
variety
side
effects.
Therefore,
there
an
urgent
need
develop
novel
therapeutic
options
overcome
these
problems.
Hydrogels
are
widely
used
in
biomedical
tissue
repairing
platform
for
loading
drugs,
proteins
stem
cells.
In
recent
years,
smart-responsive
hydrogels
have
achieved
excellent
results
drug
delivery
systems
osteoarthritis.
This
review
focuses
on
advances
endogenous
stimuli
(including
enzymes,
pH,
reactive
oxygen
species
temperature,
etc.)
responsive
exogenous
light,
shear,
ultrasound
magnetism,
osteoarthritis
treatment.
Finally,
current
limitations
application
future
prospects
smart
summarized.
