Journal of Materials Chemistry B, Год журнала: 2024, Номер unknown
Опубликована: Дек. 24, 2024
The development of multifunctional theranostic glyconanoprobes for breast cancer is distinguished by their tumor-targeting capability and enhanced antitumor efficacy, achieved through synergistic chemo-gene photothermal therapy.
Язык: Английский
Journal of Controlled Release, Год журнала: 2024, Номер 373, С. 640 - 651
Опубликована: Авг. 1, 2024
Язык: Английский
Процитировано
41
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Июнь 14, 2024
Background Monocytes play a critical role in tumor initiation and progression, with their impact on prostate adenocarcinoma (PRAD) not yet fully understood. This study aimed to identify key monocyte-related genes elucidate mechanisms PRAD. Method Utilizing the TCGA-PRAD dataset, immune cell infiltration levels were assessed using CIBERSORT, correlation patient prognosis was analyzed. The WGCNA method pinpointed 14 crucial genes. A diagnostic model focused monocytes developed combination of machine learning algorithms, while prognostic created LASSO algorithm, both which validated. Random forest gradient boosting singled out CCNA2 as most significant gene related monocytes, its function further investigated through enrichment analysis. Mendelian randomization analysis association HLA-DR high-expressing Molecular docking employed assess binding affinity targeted drugs for PRAD, experimental validation confirmed expression value Result Based identification by WGCNA, we PRAD multiple algorithms. Additionally, constructed demonstrated excellent predictive capabilities. Analysis random algorithms supported potential Gene revealed regulation cycle cellular senescence that expressing high may promote results suggested strong targeting Furthermore, immunohistochemistry experiments validated upregulation prognosis. Conclusion Our findings offer new insights into monocyte heterogeneity holds novel drug
Язык: Английский
Процитировано
24
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Авг. 29, 2024
Background Cancer stem cells (CSCs) are a subset of within tumors that possess the unique ability to self-renew and give rise diverse tumor cells. These crucial in driving metastasis, recurrence, resistance treatment. The objective this study was pinpoint essential regulatory genes associated with CSCs prostate adenocarcinoma (PRAD) assess their potential significance diagnosis, prognosis, immunotherapy patients PRAD. Method utilized single-cell analysis techniques identify cell-related evaluate relation patient prognosis PRAD through cluster analysis. By utilizing datasets employing various machine learning methods for clustering, diagnostic models were developed validated. random forest algorithm pinpointed HSPE1 as most prognostic gene among genes. Furthermore, delved into association between immune infiltration, employed molecular docking investigate relationship its compounds. Immunofluorescence staining 60 tissue samples confirmed expression correlation Result This identified 15 analysis, highlighting importance diagnosing, prognosticating, potentially treating patients. specifically linked response immunotherapy, experimental data supporting upregulation poorer prognosis. Conclusion Overall, our findings underscore significant role unveil novel target related cell.
Язык: Английский
Процитировано
24
Molecular Cancer, Год журнала: 2024, Номер 23(1)
Опубликована: Ноя. 1, 2024
Malignant bone tumors, which are difficult to treat with current clinical strategies, originate from tissues and can be classified into primary secondary types. Due the specificity of microenvironment, results traditional means treating tumors often unsatisfactory, so there is an urgent need develop new treatments for malignant tumors. Recently, nanoparticle-based approaches have shown great potential in diagnosis treatment. Nanoparticles (NPs) gained significant attention due their versatility, making them highly suitable applications tissue engineering, advanced imaging techniques, targeted drug delivery. For diagnosis, NPs enhance contrast sensitivity by integrating targeting ligands, significantly improve specific recognition localization tumor cells early detection. treatment, enable delivery, increasing accumulation at sites while reducing systemic toxicity. In conclusion, understanding microenvironment using unique properties holds promise improving disease management, enhancing treatment outcomes, ultimately quality life patients Further research development will undoubtedly contribute advancement personalized medicine field oncology.
Язык: Английский
Процитировано
18
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Янв. 21, 2025
Nucleic acid therapeutics represent a highly promising treatment approach in modern medicine, treating diseases at the genetic level. However, these face numerous challenges practical applications, particularly regarding their stability, effectiveness, cellular uptake efficiency, and limitations delivering them specifically to target tissues. To overcome obstacles, researchers have developed various innovative delivery systems, including viral vectors, lipid nanoparticles, polymer inorganic protein carriers, exosomes, antibody oligonucleotide conjugates, DNA nanostructure-based systems. These systems enhance therapeutic efficacy of nucleic drugs by improving targeting specificity, half-life vivo. In this review, we systematically discuss different types drugs, analyze major barriers encountered delivery, summarize current research progress emerging We also highlight latest advancements application for diseases, infectious cancer, brain wound healing. This review aims provide comprehensive overview drug systems' status future directions integrating nanotechnology, biomaterials science, gene editing technologies, emphasizing transformative potential precision medicine.
Язык: Английский
Процитировано
2
International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 137708 - 137708
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
6
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 282, С. 137047 - 137047
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
5
International Journal of Pharmaceutics, Год журнала: 2024, Номер 669, С. 125050 - 125050
Опубликована: Дек. 5, 2024
Язык: Английский
Процитировано
5
Materials Chemistry Frontiers, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
This paper summarizes the preparation processes of tailored chitosan-based hydrogels, along with their specific applications in bone regeneration, aiming to inspire innovative designs for hydrogels and foster expanded applications.
Язык: Английский
Процитировано
0
Precision medicine and engineering., Год журнала: 2025, Номер unknown, С. 100023 - 100023
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0