Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 24, 2024
The development of multifunctional theranostic glyconanoprobes for breast cancer is distinguished by their tumor-targeting capability and enhanced antitumor efficacy, achieved through synergistic chemo-gene photothermal therapy.
Language: Английский
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 373, P. 640 - 651
Published: Aug. 1, 2024
Language: Английский
Citations
36
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Aug. 29, 2024
Background Cancer stem cells (CSCs) are a subset of within tumors that possess the unique ability to self-renew and give rise diverse tumor cells. These crucial in driving metastasis, recurrence, resistance treatment. The objective this study was pinpoint essential regulatory genes associated with CSCs prostate adenocarcinoma (PRAD) assess their potential significance diagnosis, prognosis, immunotherapy patients PRAD. Method utilized single-cell analysis techniques identify cell-related evaluate relation patient prognosis PRAD through cluster analysis. By utilizing datasets employing various machine learning methods for clustering, diagnostic models were developed validated. random forest algorithm pinpointed HSPE1 as most prognostic gene among genes. Furthermore, delved into association between immune infiltration, employed molecular docking investigate relationship its compounds. Immunofluorescence staining 60 tissue samples confirmed expression correlation Result This identified 15 analysis, highlighting importance diagnosing, prognosticating, potentially treating patients. specifically linked response immunotherapy, experimental data supporting upregulation poorer prognosis. Conclusion Overall, our findings underscore significant role unveil novel target related cell.
Language: Английский
Citations
24
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: June 14, 2024
Background Monocytes play a critical role in tumor initiation and progression, with their impact on prostate adenocarcinoma (PRAD) not yet fully understood. This study aimed to identify key monocyte-related genes elucidate mechanisms PRAD. Method Utilizing the TCGA-PRAD dataset, immune cell infiltration levels were assessed using CIBERSORT, correlation patient prognosis was analyzed. The WGCNA method pinpointed 14 crucial genes. A diagnostic model focused monocytes developed combination of machine learning algorithms, while prognostic created LASSO algorithm, both which validated. Random forest gradient boosting singled out CCNA2 as most significant gene related monocytes, its function further investigated through enrichment analysis. Mendelian randomization analysis association HLA-DR high-expressing Molecular docking employed assess binding affinity targeted drugs for PRAD, experimental validation confirmed expression value Result Based identification by WGCNA, we PRAD multiple algorithms. Additionally, constructed demonstrated excellent predictive capabilities. Analysis random algorithms supported potential Gene revealed regulation cycle cellular senescence that expressing high may promote results suggested strong targeting Furthermore, immunohistochemistry experiments validated upregulation prognosis. Conclusion Our findings offer new insights into monocyte heterogeneity holds novel drug
Language: Английский
Citations
22
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 21, 2025
Nucleic acid therapeutics represent a highly promising treatment approach in modern medicine, treating diseases at the genetic level. However, these face numerous challenges practical applications, particularly regarding their stability, effectiveness, cellular uptake efficiency, and limitations delivering them specifically to target tissues. To overcome obstacles, researchers have developed various innovative delivery systems, including viral vectors, lipid nanoparticles, polymer inorganic protein carriers, exosomes, antibody oligonucleotide conjugates, DNA nanostructure-based systems. These systems enhance therapeutic efficacy of nucleic drugs by improving targeting specificity, half-life vivo. In this review, we systematically discuss different types drugs, analyze major barriers encountered delivery, summarize current research progress emerging We also highlight latest advancements application for diseases, infectious cancer, brain wound healing. This review aims provide comprehensive overview drug systems' status future directions integrating nanotechnology, biomaterials science, gene editing technologies, emphasizing transformative potential precision medicine.
Language: Английский
Citations
2
Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)
Published: Nov. 1, 2024
Malignant bone tumors, which are difficult to treat with current clinical strategies, originate from tissues and can be classified into primary secondary types. Due the specificity of microenvironment, results traditional means treating tumors often unsatisfactory, so there is an urgent need develop new treatments for malignant tumors. Recently, nanoparticle-based approaches have shown great potential in diagnosis treatment. Nanoparticles (NPs) gained significant attention due their versatility, making them highly suitable applications tissue engineering, advanced imaging techniques, targeted drug delivery. For diagnosis, NPs enhance contrast sensitivity by integrating targeting ligands, significantly improve specific recognition localization tumor cells early detection. treatment, enable delivery, increasing accumulation at sites while reducing systemic toxicity. In conclusion, understanding microenvironment using unique properties holds promise improving disease management, enhancing treatment outcomes, ultimately quality life patients Further research development will undoubtedly contribute advancement personalized medicine field oncology.
Language: Английский
Citations
15
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137047 - 137047
Published: Nov. 1, 2024
Language: Английский
Citations
5
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 137708 - 137708
Published: Nov. 1, 2024
Language: Английский
Citations
5
Precision medicine and engineering., Journal Year: 2025, Volume and Issue: unknown, P. 100023 - 100023
Published: March 1, 2025
Language: Английский
Citations
0
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 669, P. 125050 - 125050
Published: Dec. 5, 2024
Language: Английский
Citations
3
Materials Chemistry Frontiers, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
This paper summarizes the preparation processes of tailored chitosan-based hydrogels, along with their specific applications in bone regeneration, aiming to inspire innovative designs for hydrogels and foster expanded applications.
Language: Английский
Citations
0