Journal of the American Chemical Society,
Год журнала:
2019,
Номер
141(16), С. 6601 - 6608
Опубликована: Апрель 3, 2019
We
report
an
ultrasound-driven
gold-nanoshell-functionalized
polymer
multilayer
tubular
nanoswimmer
that
can
photomechanically
perforate
the
membrane
of
a
cancer
cell
by
assistance
near-infrared
(NIR)
light.
The
nanoswimmers
were
constructed
template-assisted
layer-by-layer
technique
and
subsequent
functionalization
Au
nanoshells
inside
big
opening.
exhibit
efficient
controllable
movement
toward
target
cells
through
manipulation
acoustic
field.
Next,
with
end-on
attachment
onto
HeLa
achieve
poration
within
0.1
s
under
irradiation
NIR
experimental
theoretical
results
suggest
instantaneous
photothermal
effect
provides
enough
photomechanical
force
to
open
membrane.
Such
NIR-light-assisted
nanoswimmers-enabled
possesses
various
advantages
including
active
targeting,
short
time,
precision
in
single
conventional
chemical
physical
techniques
could
not
and,
thus,
considerable
promise
variety
biomedical
applications
such
as
gene
delivery
artificial
insemination.
Advanced Functional Materials,
Год журнала:
2020,
Номер
30(12)
Опубликована: Янв. 21, 2020
Abstract
Nano‐
and
micromotors
are
fascinating
objects
that
can
navigate
in
complex
fluidic
environments.
Their
active
motion
be
triggered
by
external
power
sources
or
they
exhibit
self‐propulsion
using
fuel
extracted
from
their
surroundings.
The
research
field
is
rapidly
evolving
has
produced
nano/micromotors
of
different
geometrical
designs,
exploiting
a
variety
mechanisms
locomotion,
being
capable
achieving
remarkable
speeds
diverse
environments
ranging
simple
aqueous
solutions
to
media
including
cell
cultures
animal
tissue.
This
review
aims
provide
an
overview
the
recent
developments
with
focus
on
predominantly
experimental
demonstrations
various
motor
designs
developed
past
24
months.
First,
externally
driven
motors
discussed
followed
considering
fuel‐driven
approaches.
Finally,
short
future
perspective
provided.
Angewandte Chemie International Edition,
Год журнала:
2021,
Номер
60(16), С. 8750 - 8754
Опубликована: Янв. 23, 2021
Abstract
We
report
a
bubble‐propelled
Janus
gallium/zinc
(Ga/Zn)
micromotor
with
good
biocompatibility
and
biodegradability
for
active
target
treatment
of
bacteria.
The
Ga/Zn
micromotors
are
fabricated
by
asymmetrically
coating
liquid
metal
Ga
on
Zn
microparticles
display
self‐propulsion
in
simulated
gastroenteric
acid
(pH
0.5)
at
speed
up
to
383
μm
s
−1
,
propelled
hydrogen
bubbles
generated
the
zinc–acid
reaction.
This
motion
is
enhanced
Ga–Zn
galvanic
effect.
III
cations
produced
from
degradation
serve
as
built‐in
antibiotic
agent.
movement
improves
diffusion
results
significant
increase
antibacterial
efficiency
against
H.
pylori
compared
passive
microparticles.
Such
combine
self‐propulsion,
biodegradability,
Ga‐based
properties,
providing
proof
concept
bacterial
infections.
Abstract
Inspired
by
the
highly
versatile
natural
motors,
artificial
micro‐/nanomotors
that
can
convert
surrounding
energies
into
mechanical
motion
and
accomplish
multiple
tasks
are
devised.
In
past
few
years,
have
demonstrated
significant
potential
in
biomedicine.
However,
practical
biomedical
applications
of
these
small‐scale
devices
still
at
an
infant
stage.
For
successful
bench‐to‐bed
translation,
biocompatibility
micro‐/nanomotor
systems
is
central
issue
to
be
considered.
Herein,
recent
progress
reviewed,
with
a
special
focus
on
their
applications.
Through
close
collaboration
between
researches
nanoengineering,
material
chemistry,
fields,
it
expected
promising
real‐world
application
platform
based
will
emerge
near
future.
Journal of the American Chemical Society,
Год журнала:
2019,
Номер
141(16), С. 6601 - 6608
Опубликована: Апрель 3, 2019
We
report
an
ultrasound-driven
gold-nanoshell-functionalized
polymer
multilayer
tubular
nanoswimmer
that
can
photomechanically
perforate
the
membrane
of
a
cancer
cell
by
assistance
near-infrared
(NIR)
light.
The
nanoswimmers
were
constructed
template-assisted
layer-by-layer
technique
and
subsequent
functionalization
Au
nanoshells
inside
big
opening.
exhibit
efficient
controllable
movement
toward
target
cells
through
manipulation
acoustic
field.
Next,
with
end-on
attachment
onto
HeLa
achieve
poration
within
0.1
s
under
irradiation
NIR
experimental
theoretical
results
suggest
instantaneous
photothermal
effect
provides
enough
photomechanical
force
to
open
membrane.
Such
NIR-light-assisted
nanoswimmers-enabled
possesses
various
advantages
including
active
targeting,
short
time,
precision
in
single
conventional
chemical
physical
techniques
could
not
and,
thus,
considerable
promise
variety
biomedical
applications
such
as
gene
delivery
artificial
insemination.
