Chemical Engineering Journal, Год журнала: 2023, Номер 461, С. 142142 - 142142
Опубликована: Фев. 26, 2023
Язык: Английский
Advanced Science, Год журнала: 2020, Номер 7(21)
Опубликована: Окт. 4, 2020
Advances in medical robots promise to improve modern medicine and the quality of life. Miniaturization these robotic platforms has led numerous applications that leverages precision medicine. In this review, current trends micro nanorobotics for therapy, surgery, diagnosis, imaging are discussed. The use nanorobots still faces technical, regulatory, market challenges their widespread clinical settings. Nevertheless, recent translations from proof concept vivo studies demonstrate potential toward
Язык: Английский
Процитировано
331
Advanced Materials, Год журнала: 2020, Номер 33(6)
Опубликована: Июнь 24, 2020
Abstract Self‐propelled micro‐ and nanomotors (MNMs) have shown great potential for applications in the biomedical field, such as active targeted delivery, detoxification, minimally invasive diagnostics, nanosurgery, owing to their tiny size, autonomous motion, navigation capacities. To enter clinic, MNMs request biodegradability of manufacturing materials, biocompatibility chemical fuels or externally physical fields, capability overcoming various biological barriers (e.g., biofouling, blood flow, blood–brain barrier, cell membrane), vivo visual positioning navigation. Herein, recent advances synthetic motion‐tracking imaging techniques are highlighted. The challenges future research priorities also addressed. With continued attention innovation, it is believed that, future, will pave way improve drug delivery efficiency.
Язык: Английский
Процитировано
285
Angewandte Chemie International Edition, Год журнала: 2020, Номер 59(36), С. 15424 - 15446
Опубликована: Март 14, 2020
Abstract Incorporation of non‐equilibrium actions in the sequence self‐assembly processes would be an effective means to establish bio‐like high functionality hierarchical assemblies. As a novel methodology beyond self‐assembly, nanoarchitectonics, which has as its aim fabrication functional materials systems from nanoscopic units through methodological fusion nanotechnology with other scientific disciplines including organic synthesis, supramolecular chemistry, microfabrication, and bio‐process, been applied this strategy. The application factors conventional is discussed on basis examples directed assembly, Langmuir–Blodgett layer‐by‐layer assembly. In particular, structures using bio‐active components such proteins or by combination bio‐components two‐dimensional nanomaterials, are described. Methodologies described review article highlight possible approaches nanoarchitectonics concept for creation higher functionalities structural organization.
Язык: Английский
Процитировано
221
ACS Nano, Год журнала: 2020, Номер 14(8), С. 9423 - 9439
Опубликована: Июль 23, 2020
Richard Feynman's 1959 vision of controlling devices at small scales and swallowing the surgeon has inspired science-fiction Fantastic Voyage film played a crucial role in rapid development microrobotics field. Sixty years later, we are currently witnessing dramatic progress this field, with artificial micro- nanoscale robots moving within confined spaces, down to cellular level, performing wide range biomedical applications interior while addressing limitations common passive nanosystems. In review article, discuss key recent advances field micro/nanomotors toward important applications. Specifically, outline distinct capabilities motors for such illustrate how active movement nanomotors leads advantages cell penetration, accelerated intracellular sensing, effective delivery enhanced therapeutic efficiencies. We finalize by discussing future prospects challenges that micromotor technology face implementing practical By increasing our knowledge nanomotors' entry their behavior space, successfully challenges, expect next-generation will lead exciting cell-based diagnostics therapy.
Язык: Английский
Процитировано
194
Nature Communications, Год журнала: 2021, Номер 12(1)
Опубликована: Апрель 6, 2021
Abstract Aggregation-induced emission (AIE) has, since its discovery, become a valuable tool in the field of nanoscience. AIEgenic molecules, which display highly stable fluorescence an assembled state, have applications various biomedical fields—including photodynamic therapy. Engineering structure-inherent, nanomaterials with motile properties is, however, still unexplored frontier evolution this potent technology. Here, we present phototactic/phototherapeutic nanomotors where biodegradable block copolymers decorated AIE motifs can transduce radiant energy into motion and enhance thermophoretic motility driven by asymmetric Au nanoshell. The hybrid harness two photon near-infrared radiation, triggering autonomous propulsion simultaneous phototherapeutic generation reactive oxygen species. potential these to be applied therapy is demonstrated vitro, light directed species induction synergistically efficacy high level spatial control.
Язык: Английский
Процитировано
143
Advanced Materials, Год журнала: 2022, Номер 34(52)
Опубликована: Апрель 6, 2022
Cancer is one of the most intractable diseases owing to its high mortality rate and lack effective diagnostic treatment tools. Advancements in micro-/nanorobot (MNR)-assisted sensing, imaging, therapeutics offer unprecedented opportunities develop MNR-based cancer theragnostic platforms. Unlike ordinary nanoparticles, which exhibit Brownian motion biofluids, MNRs overcome viscous resistance an ultralow Reynolds number (Re << 1) environment by self-propulsion. This unique locomotion property has motivated advanced design functionalization as a basis for next-generation cancer-therapy platforms, potential precise distribution improved permeation therapeutic agents. Enhanced barrier penetration, imaging-guided operation, biosensing are additionally studied enable promising cancer-related applications MNRs. Herein, recent advances therapy comprehensively addresses, including actuation engines, diagnostics, medical targeted drug delivery; research that can have profound impact on over next decade highlighted.
Язык: Английский
Процитировано
87
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Год журнала: 2022, Номер 14(5)
Опубликована: Июль 1, 2022
Abstract Gold and silver nanoparticles (NPs) are widely used in the biomedical research both therapeutic sensing/diagnostics fronts. Both metals share some common optical properties with surface plasmon resonance being most exploited property therapeutics diagnostics. Au NPs exhibit excellent light‐to‐heat conversion efficiencies hence have found applications primarily precision oncology, while Ag antibacterial which can be harnessed biomaterials' design. constitute biosensing platforms owing to their plasmonic now routinely various platforms. The utilization of COVID‐19 pandemic was rapidly expanded mostly point‐of‐care extent therapeutics. In this review article, main physicochemical discussed selective examples from recent literature. This article is categorized under: Therapeutic Approaches Drug Discovery > Nanomedicine for Oncologic Disease Diagnostic Tools Vitro Nanoparticle‐Based Sensing Nanotechnology Biology Nanoscale Systems
Язык: Английский
Процитировано
73
Nano Today, Год журнала: 2024, Номер 55, С. 102212 - 102212
Опубликована: Фев. 26, 2024
Язык: Английский
Процитировано
20
Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 13, 2025
Abstract Multidrug‐resistant (MDR) bacteria and their associated biofilms are major causative factors in eye infections, often resulting blindness presenting considerable global health challenges. Presently, mechano–bactericidal systems, which combine distinct topological geometries with mechanical forces to physically induce bacterial apoptosis, show promising potential. However, the physical interaction process between current systems is generally based on passive diffusion or Brownian motion lacks force required for biofilm penetration; thus, featuring low antibacterial efficacy. Here, a biomimetic nanomotor (VMSNT) synthesized by functionalizing COOH‐PEG‐phenylboronic acid (PBA) virus‐like mesoporous silica, subsequent partial coating of Au caps. Enhanced self‐thermophoresis capabilities shapes, VMSNT significantly improves effects penetration. In addition, scanning electron microscope (SEM) confocal laser (CLSM) analyses demonstrate that can precisely target within infection microenvironment, facilitated PBA's ability recognize bind peptidoglycan surfaces. Remarkably, also effective eliminating MDR reducing inflammation mice models methicillin‐resistant Staphylococcus aureus (MRSA) ‐infected keratitis endophthalmitis, minimal adverse effects. Overall, such presents approach addressing challenges ocular infections.
Язык: Английский
Процитировано
3
Nano Letters, Год журнала: 2020, Номер 20(10), С. 7350 - 7358
Опубликована: Авг. 28, 2020
Increasing penetration of antibacterial agents into biofilm is a promising strategy for improvement therapeutic effect and slowdown the progression antibiotic resistance. Herein, we design near-infrared (NIR) light-driven nanoswimmer (HSMV). Under NIR light irradiation, HSMV performs efficient self-propulsion penetrates within 5 min due to photothermal conversion asymmetrically distributed AuNPs. The localized thermal (∼45 °C) thermal-triggered release vancomycin (Van) leads an combination therapy chemotherapy in one system. active motion increases effective distance (PTT) also improves index antibiotic, resulting superior removal rate (>90%) vitro. Notably, can eliminate S. aureus biofilms grown vivo under 10 laser irradiation without damage healthy tissues. This work may shed on strategies treatment biofilm-associated infections.
Язык: Английский
Процитировано
140