Sensors and Actuators B Chemical,
Год журнала:
2020,
Номер
320, С. 128432 - 128432
Опубликована: Июнь 9, 2020
Research
has
focused
on
graphene
for
developing
the
next
generation
of
label-free
biosensors,
capable
highly
sensitive
and
specific
detection
DNA
or
other
biomolecules.
The
binding
charged
analytes
to
one-atom
thick
layer
can
greatly
affect
its
electronic
properties.
However,
is
chemically
inert,
thus
surface
functionalization
through
chemical
treatment
typically
necessary
immobilize
receptors
target
biological
analyte
graphene.
In
this
work,
we
use
gas-phase
synthesized
gold
nanoparticles
(Au
NPs)
functionalize
bind
a
aptamer
surface.
employed
in
liquid
gated
field-effect
transistor
(FET)
configuration
detect
hybridization
complementary
strand,
as
well
protein
streptavidin,
at
attomolar
level
(aM,
10−18
mol
L−1).
sensor
shows
high
dynamic
detecting
range
from
aM
picomolar
(pM)
levels
(10-18
10-12
L−1),
discriminate
between
strand
single
nucleotide
polymorphism
(SNP)
containing
achieves
limit
low
15
aM.
suggests
that
decorating
biosensors
with
Au
NPs
magnetron
sputtering
inert
gas
condensing
technique
promising
method
biosensor
functionalization,
particularly
larger-area
sensors
employ
two-dimensional
materials
such
Diagnostics,
Год журнала:
2023,
Номер
13(20), С. 3246 - 3246
Опубликована: Окт. 18, 2023
Antibiotic
resistance
is
a
global
public
health
concern,
posing
significant
threat
to
the
effectiveness
of
antibiotics
in
treating
bacterial
infections.
The
accurate
and
timely
detection
antibiotic-resistant
bacteria
crucial
for
implementing
appropriate
treatment
strategies
preventing
spread
resistant
strains.
This
manuscript
provides
an
overview
current
emerging
technologies
used
bacteria.
We
discuss
traditional
culture-based
methods,
molecular
techniques,
innovative
approaches,
highlighting
their
advantages,
limitations,
potential
future
applications.
By
understanding
strengths
limitations
these
technologies,
researchers
healthcare
professionals
can
make
informed
decisions
combating
antibiotic
improving
patient
outcomes.
ACS Nano,
Год журнала:
2023,
Номер
17(15), С. 14619 - 14631
Опубликована: Июль 20, 2023
Biosensors
based
on
graphene
field
effect
transistors
(GFETs)
have
the
potential
to
enable
development
of
point-of-care
diagnostic
tools
for
early
stage
disease
detection.
However,
issues
with
reproducibility
and
manufacturing
yields
sensors,
but
also
Debye
screening
unwanted
detection
nonspecific
species,
prevented
wider
clinical
use
technology.
Here,
we
demonstrate
that
our
wafer-scalable
GFETs
array
platform
enables
meaningful
results.
As
a
case
study
high
relevance,
an
accurate
robust
portable
GFET
biosensor
pancreatic
ductal
adenocarcinoma
(PDAC)
in
patients'
plasma
through
specific
exosomes
(GPC-1
expression)
within
45
min.
In
order
facilitate
reproducible
blood
plasma,
optimized
analytical
performance
biosensors
via
application
internal
control
channel
test
protocol.
Based
samples
from
18
PDAC
patients
8
healthy
controls,
arrays
could
accurately
discriminate
between
two
groups
while
being
able
detect
cancer
stages
including
1
2.
Furthermore,
confirmed
higher
expression
GPC-1
found
concentration
was
average
more
than
magnitude
samples.
We
these
characteristics
cancerous
are
responsible
increase
number
target
surface
graphene,
leading
improved
signal
response
biosensors.
This
holds
great
promise
tool
rapid
diagnosis
cancer.
In
vivo
electrochemical
sensing
of
neurotransmitters,
neuromodulators,
and
metabolites
plays
a
critical
role
in
real-time
monitoring
various
physiological
or
psychological
processes
the
central
nervous
system.
Currently,
advanced
biosensors
technologies
have
been
emerging
as
prominent
ways
to
meet
surging
requirements
neurotransmitters
neuromodulators
ranging
from
single
cells
brain
slices,
even
entire
brain.
This
review
introduces
fundamental
working
principles
summarizes
achievements
biosensing
including
voltammetry,
amperometry,
potentiometry,
field-effect
transistor
(FET),
organic
(OECT).
According
elaborate
feature
technology,
versatile
strategies
devoted
solve
issues
associated
with
neurochemicals
under
an
intricate
environment.
Voltammetry
is
universal
technique
investigate
complex
matrices
which
could
realize
miniaturization
electrodes,
while
amperometry
serves
well-suited
approach
offering
high
temporal
resolution
favorable
for
fast
oxidation–reduction
kinetics
neurochemicals.
Potentiometry
realizes
quantitative
analysis
by
recording
potential
difference
reduced
invasiveness
compatibility.
FET
OECT
serve
amplification
higher
sensitivity
than
traditional
technologies.
Furthermore,
we
point
out
current
shortcomings
address
challenges
perspectives
Nano-Micro Letters,
Год журнала:
2019,
Номер
11(1)
Опубликована: Сен. 4, 2019
Abstract
Skin
is
the
largest
organ
of
human
body
and
can
perceive
respond
to
complex
environmental
stimulations.
Recently,
development
electronic
skin
(E-skin)
for
mimicry
sensory
system
has
drawn
great
attention
due
its
potential
applications
in
wearable
health
monitoring
care
systems,
advanced
robotics,
artificial
intelligence,
human–machine
interfaces.
Tactile
sense
one
most
important
senses
that
attracted
special
attention.
The
ability
obtain
unique
functions
using
diverse
assembly
processible
methods
rapidly
use
graphene,
celebrated
two-dimensional
material,
tactile
sensing
devices.
With
a
emphasis
on
works
achieved
since
2016,
this
review
begins
with
modification
graphene
materials
then
critically
comprehensively
summarizes
material
methods,
device
construction
technologies
signal
characterization
approaches
pressure
strain
detection
based
derivative
materials.
This
emphasizes
on:
(1)
underlying
working
principles
these
types
sensors
roles
advantages
materials;
(2)
state-of-the-art
protocols
recently
developed
high-performance
sensing,
including
representative
examples;
(3)
perspectives
current
challenges
graphene-based
E-skin
applications.
A
summary
cutting-edge
developments
intends
provide
readers
deep
understanding
future
design
high-quality
devices
paves
path
their
commercial
field
E-skin.
Nature Communications,
Год журнала:
2019,
Номер
10(1)
Опубликована: Апрель 4, 2019
Abstract
Due
to
ultra-high
reactivity,
direct
determination
of
free
radicals,
especially
hydroxyl
radical
(•OH)
with
ultra-short
lifetime,
by
field-effect
transistor
(FET)
sensors
remains
a
challenge,
which
hampers
evaluating
the
role
that
plays
in
physiological
and
pathological
processes.
Here,
we
develop
•OH
FET
sensor
graphene
channel
functionalized
metal
ion
indicators.
At
electrolyte/graphene
interface,
highly
reactive
cuts
cysteamine
release
ions,
resulting
surface
charge
de-doping
current
response.
By
this
inner-cutting
strategy,
is
selectively
detected
concentration
down
10
−9
M.
Quantitative
doping
enables
modulation
device
sensitivity
quasi-quantitative
detection
generated
aqueous
solution
or
from
living
cells.
Owing
its
high
sensitivity,
selectivity,
real-time
label-free
response,
capability
for
user-friendly
portable
feature,
it
valuable
biological
research,
human
health,
environmental
monitoring,
etc.
This
review
provides
a
critical
overview
of
current
developments
on
nanoelectronic
biochemical
sensors
based
graphene.
Composed
single
layer
conjugated
carbon
atoms,
graphene
has
outstanding
high
carrier
mobility
and
low
intrinsic
electrical
noise,
but
chemically
inert
surface.
Surface
functionalization
is
therefore
crucial
to
unravel
sensitivity
selectivity
for
the
detection
targeted
analytes.
To
achieve
optimal
performance
transistors
sensing,
tuning
surface
properties
via
passivation
highlighted,
as
well
its
operation
by
utilizing
multifrequency
ambipolar
configuration
frequency
measurement
scheme
overcome
Debye
screening
noise
highly
sensitive
detection.
Potential
applications
prospectives
ultrasensitive
electronic
ranging
from
environmental
monitoring
food
safety,
healthcare
medical
diagnosis,
life
science
research,
are
presented
well.
