Current and Future Technologies for the Detection of Antibiotic-Resistant Bacteria

Diagnostics, Journal Year: 2023, Volume and Issue: 13(20), P. 3246 - 3246

Published: Oct. 18, 2023

Antibiotic resistance is a global public health concern, posing significant threat to the effectiveness of antibiotics in treating bacterial infections. The accurate and timely detection antibiotic-resistant bacteria crucial for implementing appropriate treatment strategies preventing spread resistant strains. This manuscript provides an overview current emerging technologies used bacteria. We discuss traditional culture-based methods, molecular techniques, innovative approaches, highlighting their advantages, limitations, potential future applications. By understanding strengths limitations these technologies, researchers healthcare professionals can make informed decisions combating antibiotic improving patient outcomes.

Language: Английский

---

Graphene Sensor Arrays for Rapid and Accurate Detection of Pancreatic Cancer Exosomes in Patients’ Blood Plasma Samples

ACS Nano, Journal Year: 2023, Volume and Issue: 17(15), P. 14619 - 14631

Published: July 20, 2023

Biosensors based on graphene field effect transistors (GFETs) have the potential to enable development of point-of-care diagnostic tools for early stage disease detection. However, issues with reproducibility and manufacturing yields sensors, but also Debye screening unwanted detection nonspecific species, prevented wider clinical use technology. Here, we demonstrate that our wafer-scalable GFETs array platform enables meaningful results. As a case study high relevance, an accurate robust portable GFET biosensor pancreatic ductal adenocarcinoma (PDAC) in patients' plasma through specific exosomes (GPC-1 expression) within 45 min. In order facilitate reproducible blood plasma, optimized analytical performance biosensors via application internal control channel test protocol. Based samples from 18 PDAC patients 8 healthy controls, arrays could accurately discriminate between two groups while being able detect cancer stages including 1 2. Furthermore, confirmed higher expression GPC-1 found concentration was average more than magnitude samples. We these characteristics cancerous are responsible increase number target surface graphene, leading improved signal response biosensors. This holds great promise tool rapid diagnosis cancer.

Language: Английский

---

Functionalization of graphene layers and advancements in device applications

Carbon, Journal Year: 2019, Volume and Issue: 152, P. 954 - 985

Published: June 28, 2019

Language: Английский

---

Graphene Nanostructure-Based Tactile Sensors for Electronic Skin Applications

Nano-Micro Letters, Journal Year: 2019, Volume and Issue: 11(1)

Published: Sept. 4, 2019

Abstract Skin is the largest organ of human body and can perceive respond to complex environmental stimulations. Recently, development electronic skin (E-skin) for mimicry sensory system has drawn great attention due its potential applications in wearable health monitoring care systems, advanced robotics, artificial intelligence, human–machine interfaces. Tactile sense one most important senses that attracted special attention. The ability obtain unique functions using diverse assembly processible methods rapidly use graphene, celebrated two-dimensional material, tactile sensing devices. With a emphasis on works achieved since 2016, this review begins with modification graphene materials then critically comprehensively summarizes material methods, device construction technologies signal characterization approaches pressure strain detection based derivative materials. This emphasizes on: (1) underlying working principles these types sensors roles advantages materials; (2) state-of-the-art protocols recently developed high-performance sensing, including representative examples; (3) perspectives current challenges graphene-based E-skin applications. A summary cutting-edge developments intends provide readers deep understanding future design high-quality devices paves path their commercial field E-skin.

Language: Английский

---

Acetylcholine biosensor based on the electrochemical functionalization of graphene field-effect transistors

Biosensors and Bioelectronics, Journal Year: 2019, Volume and Issue: 148, P. 111796 - 111796

Published: Oct. 22, 2019

Language: Английский

---

2D metal oxide nanoflakes for sensing applications: Review and perspective

Sensors and Actuators B Chemical, Journal Year: 2018, Volume and Issue: 272, P. 369 - 392

Published: June 1, 2018

Language: Английский

---

Free radical sensors based on inner-cutting graphene field-effect transistors

Nature Communications, Journal Year: 2019, Volume and Issue: 10(1)

Published: April 4, 2019

Abstract Due to ultra-high reactivity, direct determination of free radicals, especially hydroxyl radical (•OH) with ultra-short lifetime, by field-effect transistor (FET) sensors remains a challenge, which hampers evaluating the role that plays in physiological and pathological processes. Here, we develop •OH FET sensor graphene channel functionalized metal ion indicators. At electrolyte/graphene interface, highly reactive cuts cysteamine release ions, resulting surface charge de-doping current response. By this inner-cutting strategy, is selectively detected concentration down 10 −9 M. Quantitative doping enables modulation device sensitivity quasi-quantitative detection generated aqueous solution or from living cells. Owing its high sensitivity, selectivity, real-time label-free response, capability for user-friendly portable feature, it valuable biological research, human health, environmental monitoring, etc.

Language: Английский

---

TMAVA, a Metabolite of Intestinal Microbes, Is Increased in Plasma From Patients With Liver Steatosis, Inhibits γ-Butyrobetaine Hydroxylase, and Exacerbates Fatty Liver in Mice

Gastroenterology, Journal Year: 2020, Volume and Issue: 158(8), P. 2266 - 2281.e27

Published: Feb. 25, 2020

Language: Английский

---

Ultrasensitive Field‐Effect Biosensors Enabled by the Unique Electronic Properties of Graphene

Small, Journal Year: 2019, Volume and Issue: 16(15)

Published: Oct. 8, 2019

This review provides a critical overview of current developments on nanoelectronic biochemical sensors based graphene. Composed single layer conjugated carbon atoms, graphene has outstanding high carrier mobility and low intrinsic electrical noise, but chemically inert surface. Surface functionalization is therefore crucial to unravel sensitivity selectivity for the detection targeted analytes. To achieve optimal performance transistors sensing, tuning surface properties via passivation highlighted, as well its operation by utilizing multifrequency ambipolar configuration frequency measurement scheme overcome Debye screening noise highly sensitive detection. Potential applications prospectives ultrasensitive electronic ranging from environmental monitoring food safety, healthcare medical diagnosis, life science research, are presented well.

Language: Английский

---

Graphene-based field effect transistor biosensors for breast cancer detection: A review on biosensing strategies

Carbon, Journal Year: 2020, Volume and Issue: 172, P. 431 - 453

Published: Oct. 16, 2020

Language: Английский

---