Chemical Society Reviews,
Год журнала:
2022,
Номер
51(10), С. 4175 - 4198
Опубликована: Янв. 1, 2022
Polyphenolic
materials
are
a
class
of
fascinating
and
versatile
bioinspired
for
biointerfacial
engineering.
In
particular,
due
to
the
presence
active
chemical
groups,
series
unique
physicochemical
properties
become
accessible
tunable
as-prepared
polyphenolic
platforms,
which
could
delicately
regulate
cell
activities
via
cell-material
contact-dependent
interactions.
More
interestingly,
polyphenols
also
affect
behaviors
contact-independent
manner,
arise
their
intrinsically
functional
characteristics
(e.g.,
antioxidant
photothermal
behaviors).
As
such,
comprehensive
understanding
on
relationship
between
material
desired
biomedical
applications,
as
well
underlying
mechanism
at
cellular
molecular
level
would
provide
design
principles
accelerate
lab-to-clinic
translation
platforms.
this
review,
we
firstly
give
brief
overview
hallmarks
governed
by
surrounding
cues,
followed
introduction
engineering
strategies.
Subsequently,
detailed
discussion
cell-polyphenols
interfacial
interaction
was
carefully
provided.
Lastly,
applications
were
elaborated.
We
believe
that
review
guidances
rational
multifunctional
extend
application
window.
Chemical Reviews,
Год журнала:
2021,
Номер
121(4), С. 1981 - 2019
Опубликована: Янв. 25, 2021
Since
the
first
connection
between
Fenton
chemistry
and
biomedicine,
numerous
studies
have
been
presented
in
this
field.
Comprehensive
presentation
of
guidance
from
a
summary
its
representative
applications
cancer
therapy
would
help
us
understand
promote
further
development
This
comprehensive
review
supplies
basic
information
regarding
chemistry,
including
reactions
Fenton-like
reactions.
Subsequently,
current
progress
is
discussed,
with
some
corresponding
examples
presented.
Furthermore,
strategies
for
optimizing
performance
chemodynamic
guided
by
are
highlighted.
Most
importantly,
future
perspectives
on
combination
biomedicine
or
wider
range
catalytic
approaches
We
hope
that
will
attract
positive
attention
materials
science,
fields
tighten
their
connections.
Abstract
Chemodynamic
therapy
(CDT),
a
novel
cancer
therapeutic
strategy
defined
as
the
treatment
using
Fenton
or
Fenton‐like
reaction
to
produce
•OH
in
tumor
region,
was
first
proposed
by
Bu,
Shi,
and
co‐workers
2016.
Recently,
with
rapid
development
of
nanomaterials,
CDT
has
attracted
tremendous
attention
because
its
unique
advantages:
1)
It
is
tumor‐selective
low
side
effects;
2)
process
does
not
depend
on
external
field
stimulation;
3)
it
can
modulate
hypoxic
immunosuppressive
microenvironment;
4)
cost
low.
In
addition
Fe‐involved
strategies,
reaction‐mediated
strategies
have
also
been
proposed,
which
are
based
many
other
metal
elements
including
copper,
manganese,
cobalt,
titanium,
vanadium,
palladium,
silver,
molybdenum,
ruthenium,
tungsten,
cerium,
zinc.
Moreover,
combined
therapies
like
chemotherapy,
radiotherapy,
phototherapy,
sonodynamic
therapy,
immunotherapy
for
achieving
enhanced
anticancer
effects.
Besides,
there
studies
that
extend
application
antibacterial
field.
This
review
introduces
latest
advancements
nanomaterials‐involved
from
2018
present
proposes
current
limitations
well
future
research
directions
related
Advanced Materials,
Год журнала:
2021,
Номер
33(22)
Опубликована: Апрель 19, 2021
Abstract
Polyphenols,
the
phenolic
hydroxyl
group‐containing
organic
molecules,
are
widely
found
in
natural
plants
and
have
shown
beneficial
effects
on
human
health.
Recently,
polyphenol‐containing
nanoparticles
attracted
extensive
research
attention
due
to
their
antioxidation
property,
anticancer
activity,
universal
adherent
affinity,
thus
great
promise
preparation,
stabilization,
modification
of
multifunctional
nanoassemblies
for
bioimaging,
therapeutic
delivery,
other
biomedical
applications.
Additionally,
metal−polyphenol
networks,
formed
by
coordination
interactions
between
polyphenols
metal
ions,
been
used
prepare
an
important
class
surface
modification,
drug
disease
treatments.
By
focusing
different
materials
(e.g.,
inorganic
materials,
polymers,
proteins,
nucleic
acids),
a
comprehensive
review
synthesis
properties
is
provided.
Moreover,
remarkable
versatility
applications,
including
biodetection,
multimodal
protein
gene
bone
repair,
antibiosis,
cancer
theranostics
also
demonstrated.
Finally,
challenges
faced
future
regarding
discussed.
Advanced Materials,
Год журнала:
2020,
Номер
33(4)
Опубликована: Дек. 2, 2020
Abstract
The
past
decades
have
witnessed
hyperthermia
therapy
(HTT)
as
an
emerging
strategy
against
malignant
tumors.
Nanomaterial‐based
photothermal
(PTT)
and
magnetic
(MHT),
highly
effective
noninvasive
treatment
models,
offer
advantages
over
other
strategies
in
the
of
different
types
However,
both
PTT
MHT
cannot
completely
cure
cancer
due
to
recurrence
distal
metastasis.
In
recent
years,
immunotherapy
has
attracted
widespread
attention
owing
its
capability
activate
body's
own
natural
defense
identify,
attack,
eradicate
cells.
Significant
efforts
been
devoted
studying
activated
immune
responses
caused
by
hyperthermia‐ablated
this
article,
synergistic
mechanism
HTT
immunotherapy,
including
immunogenic
cell
death
reversal
immunosuppressive
tumor
microenvironment
is
discussed.
reports
combination
or
HTT‐based
multimodal
with
immunoadjuvant
exploitation,
checkpoint
blockade
therapy,
adoptive
cellular
are
summarized.
As
highlighted,
these
could
achieve
synergistically
enhanced
therapeutic
outcomes
primary
tumors
metastatic
lesions,
prevent
recurrence,
prolong
survival
period.
Finally,
current
challenges
prospective
developments
HTT‐synergized
also
reviewed.
Chemical Society Reviews,
Год журнала:
2021,
Номер
50(4), С. 2839 - 2891
Опубликована: Янв. 1, 2021
Supramolecular
cancer
nanotheranostics
have
shown
promising
potentials
in
early-stage
diagnosis
and
personal
therapy.
Herein,
we
summarize
the
progress
of
supramolecular
provide
guidance
for
designing
new
targeted
theranostic
agents.
Advanced Materials,
Год журнала:
2021,
Номер
33(48)
Опубликована: Сен. 27, 2021
Chemodynamic
therapy
(CDT)
uses
the
tumor
microenvironment-assisted
intratumoral
Fenton
reaction
for
generating
highly
toxic
hydroxyl
free
radicals
(•OH)
to
achieve
selective
treatment.
However,
limited
efficiency
restricts
therapeutic
efficacy
of
CDT.
Recent
years
have
witnessed
impressive
development
various
strategies
increase
reaction.
The
introduction
these
reinforcement
can
dramatically
improve
treatment
CDT
and
further
promote
enhanced
(ECDT)-based
multimodal
anticancer
treatments.
In
this
review,
authors
systematically
introduce
strategies,
from
their
basic
working
principles,
mechanisms
representative
clinical
applications.
Then,
ECDT-based
is
discussed,
including
how
integrate
emerging
accelerating
therapy,
as
well
synergistic
ECDT
other
methods.
Eventually,
future
direction
challenges
therapies
are
elaborated,
highlighting
key
scientific
problems
unsolved
technical
bottlenecks
facilitate
translation.
Theranostics,
Год журнала:
2021,
Номер
11(13), С. 6370 - 6392
Опубликована: Янв. 1, 2021
As
one
of
the
most
important
cancer
treatment
strategies,
conventional
chemotherapy
has
substantial
side
effects
and
leads
easily
to
failure.
Therefore,
exploring
developing
more
efficient
methods
enhance
is
an
urgently
problem
that
must
be
solved.
With
development
nanotechnology,
nanomedicine
showed
a
good
application
prospect
in
improving
chemotherapy.
In
this
review,
we
aim
present
discussion
on
significant
research
progress
for
enhanced
First,
increased
enrichment
drugs
tumor
tissues
relying
different
targeting
ligands
promoting
tissue
penetration
are
summarized.
Second,
specific
subcellular
organelle-targeted
discussed.
Next,
combinational
strategies
reverse
multidrug
resistance
(MDR)
improve
effective
intracellular
concentration
therapeutics
Furthermore,
advantages
combination
therapy
emphasized.
Finally,
discuss
major
problems
facing
therapeutic
chemotherapy,
propose
possible
future
directions
field.
Chemical Society Reviews,
Год журнала:
2021,
Номер
50(7), С. 4432 - 4483
Опубликована: Янв. 1, 2021
Phenolics
are
ubiquitous
in
nature
and
have
gained
immense
research
attention
because
of
their
unique
physiochemical
properties
widespread
industrial
use.
In
recent
decades,
accessibility,
versatile
reactivity,
relative
biocompatibility
catalysed
phenolic-enabled
nanotechnology
(PEN)
particularly
for
biomedical
applications
which
been
a
major
benefactor
this
emergence,
as
largely
demonstrated
by
polydopamine
polyphenols.
Therefore,
it
is
imperative
to
overveiw
the
fundamental
mechanisms
synthetic
strategies
PEN
state-of-the-art
provide
timely
comprehensive
summary.
review,
we
will
focus
on
principles
involved
summarize
use
toolkit
particle
engineering
bottom-up
synthesis
nanohybrid
materials.
Specifically,
discuss
attractive
forces
between
phenolics
complementary
structural
motifs
confined
systems
synthesize
high-quality
products
with
controllable
size,
shape,
composition,
well
surface
chemistry
function.
Additionally,
phenolic's
numerous
biosensing,
bioimaging,
disease
treatment
be
highlighted.
This
review
aims
guidelines
new
scientists
field
serve
an
up-to-date
compilation
what
has
achieved
area,
while
offering
expert
perspectives
PEN's
translational
research.
